Abstract: The present invention discloses system and method for measuring coefficient variance of resonance frequency of musculoskeletal system. In this regards, the system comprises a signal generation module, a signal retrieval module, and a signal analysis module. The purpose of the system is to measure resonance frequencies of a musculoskeletal system which implanted with an arthroplasty in order to form a statistical sampling space of resonance frequencies. Therefore a coefficient variance of the statistical sampling space of resonance frequencies can be derived. Consequently, the magnitude of this coefficient variance is used for determining whether the implated arthroplasty loose.