Abstract: The present invention relates to an antagonist of interleukin-17B receptor (IL-17RB) which features interruption of the interaction of IL-17RB and MLK4. The present invention also relates to use of such antagonist for treatment of diseases or disorders associated with IL-17RB activation. Further disclosed is a phosphorylated IL-17RB as a biomarker for predicting prognosis and/or monitoring progression of cancer.

Abstract: An LED indicator device is mounted in an AC power plug or socket and electrically connected in parallel with an AC power source. The LED indicator device includes a driving/current-limiting circuit to which an LED lighting circuit is coupled. The driving/current-limiting circuit includes a driving/current-limiting capacitor and a discharge resistor connected in parallel with the driving/current-limiting capacitor. The LED lighting circuit includes an LED, a protective instantaneous current-limiting resistor coupled to the LED, a rectifying diode connected in parallel with the LED, and a protective instantaneous voltage-limiting capacitor connected in parallel with the LED. The LED is lit to show the position and on/off state of the AC power plug or socket. Three LEDs emitting different colors and associated driving/current-limiting circuits and associated LED lighting circuits can be utilized to indicate incorrect power connection or short circuit of the AC power plug or socket.

Abstract: An LED indicator device is mounted in an AC power plug or socket and electrically connected in parallel with an AC power source. The LED indicator device includes a driving/current-limiting circuit to which an LED lighting circuit is coupled. The driving/current-limiting circuit includes a driving/current-limiting capacitor and a discharge resistor connected in parallel with the driving/current-limiting capacitor. The LED lighting circuit includes an LED, a protective instantaneous current-limiting resistor coupled to the LED, a rectifying diode connected in parallel with the LED, and a protective instantaneous voltage-limiting capacitor connected in parallel with the LED. The LED is lit to show the position and on/off state of the AC power plug or socket. Three LEDs emitting different colors and associated driving/current-limiting circuits and associated LED lighting circuits can be utilized to indicate incorrect power connection or short circuit of the AC power plug or socket.

Abstract: An extension cord includes a cable, a plug on an end of the cable, and a socket casing on the other end of the cable. A lighting device is mounted in the plug or the socket casing. The lighting device includes an LED electrically connected in parallel to conductive wires in the cable and a DC converting circuit electrically connected to the LED. The DC converting circuit converts an AC voltage from the plug into a DC voltage supplied to the LED for lighting the LED. Light beams emitted by the LED transmit through the plug or the socket casing to show the extension cord and to indicate on/off state of the extension cord. Another lighting device may be mounted in the other of the plug and the socket casing. An optical fiber may be mounted in the cable and lit to show the cable.

Abstract: An automatic light-coupling system for optical components suitable for coupling and packaging an optical assembly, comprising: a light-coupling device comprising: a coupling media installer comprising a horizontal table for moving a coupling media along a horizontal direction; a vertical table for moving a coupling media along a vertical direction; and a coupling media table for clipping a connector of the coupling media; and an optical component installer comprising a focus-control table for controlling the focusing and withdrawing of the optical components; a horizontal turntable for controlling the horizontal rotation of the optical components; a vertical turntable for controlling the vertical rotation of the optical components; an adapter of the optical component for holding the optical component, in which a pinhole is placed in front of the optical component so that the light emitted from the optical component passes through the pinhole and forms a light beam that is rotated to correct the assembly incli