Abstract: An implantation device for prompt subcutaneous implantation of a sensor to measure a physiological signal of an analyte in a biofluid of a living body is disclosed. The implantation device includes a housing, an implantation module, a detachable module and a bottom cover. The housing has a bottom opening. The implantation module includes an implanting device and a needle extracting device. The detachable module includes the sensor detachably engaged with the implantation module; and a base configured to mount the sensor thereon. The bottom cover is detachably coupled to the bottom opening so that the housing and the bottom cover together form an accommodating space. The implantation module and the detachable module are accommodated in the accommodating space. The bottom cover has an operating portion configured to bear a force, and a supporting portion is formed on the opposite end of the operating portion.

Abstract: The present invention provides a measuring method for prolonging a usage lifetime of a biosensor to measure a physiological signal representative of a physiological parameter associated with an analyte in a biofluid. The biosensor includes two working electrodes at least partially covered by a chemical reagent and two counter electrodes having silver and a silver halide, and each silver halide has an initial amount.

Abstract: A physiological signal monitoring device includes a sensing member and a transmitter connected to the sensing member and including a circuit board that has electrical contacts, and a connecting port, which includes a socket communicated to the circuit board and a plurality of conducting springs disposed at two opposite sides of the socket. The sensing member is removably inserted into the socket. The conducting springs are electrically connected to the electrical contacts and the sensing member for enabling electric connection therebetween. Each of the conducting springs is frictionally rotated by the sensing member during insertion of the sensing member into the socket and removal of the sensing member from the socket.

Abstract: The present invention provides a measuring method for prolonging a usage lifetime of a micro biosensor implanted subcutaneously to measure a physiological signal associated with an analyte. The micro biosensor includes a working electrode and a counter electrode, wherein the counter electrode includes silver and a silver halide having an initial amount. The method includes cyclic steps of: applying a measurement voltage to drive the working electrode to measure the physiological signal, where the silver halide is consumed by a specific amount; stopping applying the measurement voltage; and whenever the physiological parameter is obtained, applying a replenishment voltage to drive the counter electrode, thereby the silver halide of a replenishment amount being replenished to the counter electrode, wherein a guarding value of a sum of the replenishment amount and the initial amount subtracting the consumption amount is controlled within a range of the initial amount plus or minus a specific value.

Abstract: The present invention provides a measuring method for prolonging a usage lifetime of the micro biosensor to measure a physiological signal associated with an analyte. The micro biosensor includes a working electrode, a counter electrode including silver and a silver halide having an initial amount, and an auxiliary electrode.

Abstract: A physiological signal monitoring device includes a sensing member and a transmitter connected to the sensing member and including a circuit board that has electrical contacts, and a connecting port, which includes a socket communicated to the circuit board and a plurality of steel balls. The sensing member is removably inserted into the socket. The steel balls are electrically connected to the electrical contacts and the sensing member for enabling electric connection therebetween. Each of the steel balls is frictionally rotated by the sensing member during insertion of the sensing member into the socket and removal of the sensing member from the socket.

Abstract: The present invention discloses a holder carrying thereon a sensor to measure a physiological signal of an analyte in a biological fluid, wherein the sensor has a signal detection end and a signal output end, and the holder includes an implantation hole being a channel for implanting the sensor and containing a part of the sensor, a waterproof seal disposed above the implantation hole, and an elastic divider disposed in the implantation hole to separate the implantation hole and covering all over a cross-sectional area of the implantation hole.

Abstract: An implantable micro-biosensor includes a substrate, a first working electrode, at least one second working electrode, and at least one counter electrode. The first working electrode includes a first sensing section driven by a first potential difference to measure a physiological signal. The second working electrode includes a second sensing section driven by a second potential difference to consume an interfering substance. The counter electrode cooperates with the first working electrode to measure the physiological signal, cooperates with the second working electrode to consume the interfering substance, and selectively cooperates with the first or second working electrode to regenerate silver halide.

Abstract: A physiological signal monitoring device includes a base including a base body that has a bottom plate and an opening, a biosensor mounted to the base, and a transmitter removably mounted to the base body. The base further includes a first coupling structure disposed on a top surface of the bottom plate, and the transmitter includes a second coupling structure coupled to the first coupling structure when the transmitter is mounted to the base body. When the first and second coupling structures are coupled to each other, they are disposed to be distal from a periphery cooperatively defined by the base and the transmitter. They are uncoupled from each other when an external force is applied through the opening of the base body to separate the transmitter from the base.

Abstract: The present invention provides a method for reducing measurement interference of a micro biosensor, wherein the micro biosensor is used to measure a target analyte in a biofluid during a period, and the period includes first sub-time zones and second sub-time zones. The method includes performing a interference eliminating action in the T1 zone, in which a second sensing section of the micro biosensor consumes an interferant, performing a measurement action in a first T2 zone, in which a first sensing section of the micro biosensor measures and outputs a physiological signal, performing the interference eliminating action in the next T1 zone to consume an interferant, performing the measurement action in the next T2 zone to measure and output a physiological signal, and so on, to obtain a value data of the physiological parameter in all respective T2 zones during the period, and to reduce a measurement interference.

Abstract: An insertion device includes a cover body and an insertion module. The insertion module is disposed in the cover body, and includes a main body, an insertion seat, a pre-compressed first elastic member, a retraction seat and a pre-compressed second elastic member. The restoring force of the pre-compressed first elastic member is configured not to act on the cover body during depression of the cover body.

Abstract: The present invention discloses a holder carrying thereon a sensor to measure a physiological signal of an analyte in a biological fluid, wherein the sensor has a signal detection end and a signal output end, and the holder includes an implantation hole being a channel for implanting the sensor and containing a part of the sensor, a containing indentation containing the signal output end, a fixing indentation fixing thereto the sensor and communicating with the containing indentation, a waterproof seal disposed above the implantation hole, an elastic divider disposed in the implantation hole to separate the implantation hole and covering all over a cross-sectional area of the implantation hole, and a blocking element disposed between the implantation hole and the fixing indentation to hold the sensor.

Abstract: An insertion device includes an upper casing, a lower casing and an insertion module. When the lower casing is coupled to the upper casing, an abutment portion of the lower casing limits movement of a casing engaging structure of the upper casing, such that the upper casing cannot move downwardly so as to prevent unintentional insertion operation of the insertion device.

Abstract: The present invention discloses a holder carrying thereon a sensor to measure a physiological signal of an analyte in a biological fluid, wherein the sensor has a signal detection end and a signal output end, and the holder includes an implantation hole being a channel for implanting the sensor and containing a part of the sensor, a fixing indentation containing the sensor, a filler disposed in the fixing indentation to retain the sensor in the holder, and a blocking element disposed between the implantation hole and the fixing indentation to hold the sensor in the holder and restrict the filler in the fixing indentation.

Abstract: A physiological signal monitoring device includes a base and a transmitter. The base is provided with a biosensor. The transmitter is removably coupled to the base, and includes a casing and an electrostatic-discharge protective unit. The casing has a socket for the biosensor to be removably inserted thereinto. The electrostatic-discharge protective unit is disposed to at least surround the periphery of the socket to dispel static electricity when electrostatic discharge occurs.

Abstract: An insertion device includes a cover body, an insertion module. The insertion module is disposed in the cover body, and includes a main body, an insertion seat, a first elastic member, a retraction seat and a second elastic member. When the cover body is depressed, the insertion seat is driven by the first elastic member to perform an automatic-insertion operation and to collapse a limiting structure between the insertion seat and the cover body. A limiting structure between the insertion seat and the retraction seat collapses upon the collapse of the limiting structure between the insertion seat and the cover body, so that the retraction seat is driven by the second elastic member to perform an automatic-retraction operation.

Abstract: The present invention discloses a holder carrying thereon a sensor to measure a physiological signal of an analyte in a biological fluid, wherein the sensor has a signal detection end and a signal output end, and the holder includes an implantation hole being a channel for implanting therethrough the sensor and containing a part of the sensor, and a containing indentation containing the signal output end, wherein the containing indentation has a surrounding wall kept apart from the signal output end to define a space.

Abstract: A method for manufacturing an implantable micro-biosensor includes the steps of: a) providing a substrate, b) forming on a first surface of the substrate a first working electrode which at least includes a first sensing section including a first conductive material, c) forming on the first surface of the substrate at least one second working electrode which at least includes a second sensing section disposed proximate to at least one side of the first sensing section, and d) forming a chemical reagent layer which at least covers the first conductive material of the first sensing section and which reacts with the analyte to produce a product.

Abstract: A physiological signal monitoring device includes a sensing member and a transmitter connected to the sensing member and including a circuit board that has electrical contacts, and a connecting port, which includes a socket communicated to the circuit board and a plurality of conducting springs. The sensing member is removably inserted into the socket. The conducting springs are electrically connected to the electrical contacts and the sensing member for enabling electric connection therebetween. Each of the conducting springs is frictionally moved by the sensing member during insertion of the sensing member into the socket and removal of the sensing member from the socket.

Abstract: An air-tight desiccating container for storing therein a sensor to be implanted into a subcutaneous portion of a living body is disclosed. The air-tight desiccating container includes a housing, an implanting module, a detachable module mounted on the housing, a bottom cover and a desiccating element. The housing includes an accommodating space and a bottom opening having a first joint portion. The implanting module is mounted in the housing and includes a needle implanting device and a needle extracting device. The detachable module includes the sensor having a chemical reagent for measuring a physiological signal from the living body having a skin surface and a lower mount base configured to assemble the sensor thereon. The bottom cover is detachably coupled to the bottom opening, and has a second joint portion.