Abstract: Marinopyrrole derivatives and methods for their synthesis and use are described herein. Novel cyclic and symmetric marinopyrroles with triazole substituents having antibacterial activity against resistant bacterial strains, such as MRSA are introduced. Also provided are methods of using the compounds for treating or preventing cancer and/or microbial infections.

Abstract: Marinopyrrole derivatives and methods for their synthesis and use are described herein. Novel cyclic and symmetric marinopyrroles with triazole substituents having antibacterial activity against resistant bacterial strains, such as MRSA are introduced. Also provided are methods of using the compounds for treating or preventing cancer and/or microbial infections.

Abstract: Marinopyrrole derivatives and methods for their synthesis and use are described herein. Novel cyclic and symmetric marinopyrroles with triazole substituents having antibacterial activity against resistant bacterial strains, such as MRSA are introduced. Also provided are methods of using the compounds for treating or preventing cancer and/or microbial infections.

Abstract: Symmetrical marinopyrrole derivatives are disclosed herein, as is a synthetic route for producing these compounds. Also disclosed are methods of using symmetrical marinopyrrole derivatives to treat bacterial pathogens, like MRSE, MSSA and MRSA.

Abstract: Marinopyrrole derivatives and methods for their synthesis and use are described herein. Novel cyclic and symmetric marinopyrroles with triazole substituents having antibacterial activity against resistant bacterial strains, such as MRSA are introduced. Also provided are methods of using the compounds for treating or preventing cancer and/or microbial infections.

Abstract: Symmetrical marinopyrrole derivatives are disclosed herein, as is a synthetic route for producing these compounds. Also disclosed are methods of using symmetrical marinopyrrole derivatives to treat bacterial pathogens, like MRSE, MSSA and MRSA.

Abstract: A sample placed under a microscope is illuminated by light from a laser beam. Raman scattered light is passed back via a dichroic filter to various optical components which analyse the Raman spectrum, and thence to a CCD detector. The optical components for analysing the Raman spectrum include tunable dielectric filters in a filter wheel; a Fabry-Perot etalon; and a diffraction grating. These various components may be swapped into the optical path as desired, for example using movable mirrors, enabling the apparatus to be used very flexibly for a variety of different analysis procedures. Various novel analysis methods are also described.

Abstract: In a Raman microscope, Raman scattered light from an illuminated area on a sample 10 is collected by an objective 12 and imaged by a lens 18 onto a detector in an image plane 20. A filter 16 selects only light of a desired Raman wavenumber shift. Since the tuning of this filter is sensitive to the angle of incidence, it is placed after the lens 18 instead of before it, and the distance from the objective 12 to the lens 18 is made substantially equal to the focal length of the lens 18. This ensures that chief rays 14A',14B' from different points on the sample 10 pass through the filter 16 at the same angle of incidence. The wavenumber selected by the filter is therefore the same for light from all points on the sample, which it would not be if the filter were placed before the lens 18.

Abstract: A sample placed under a microscope is illuminated by light from a laser beam. Raman scattered light is passed back via a dichroic filter to various optical components which analyse the Raman spectrum, and thence to a CCD detector. The optical components for analysing the Raman spectrum include tunable dielectric filters in a filter wheel; a Fabry-Perot etalon; and a diffraction grating. These various components may be swapped into the optical path as desired, for example using movable mirrors, enabling the apparatus to be used very flexibly for a variety of different analysis procedures. Various novel analysis methods are also described.

Abstract: A sample (14) is illuminated by light from a laser source (16), which is reflected to it by a dichroic filter (18) and passed through a microscope objective (20). The microscope objective (20) focusses a two dimensional image of the illuminated area onto a detector (22). On the way to the detector (22), the light passes through an interference filter (26), which selects a desired line from the Raman spectrum scattered by the sample (14). The filter (26) can be tuned to any desired Raman line by rotating it through various angles of incidence (.THETA.), about an axis (28) perpendicular to the optical axis.