Abstract: The present invention relates to chimeric papilloma virus L1 proteins and polynucleotides encoding thereof, and also to HPV virus-like particles and the preparation methods thereof. Said chimeric papilloma virus L1 protein comprises an N-terminal fragment derived from L1 protein of the first papilloma virus type, said N-terminal fragment maintains the immunogenicity of the L1 protein of the corresponding type of HPV; and a C-terminal fragment derived from L1 protein of the second papilloma virus type, said L1 protein of the second papilloma virus type has a better expression level and a better solubility compared to the L1 proteins of other HPV types; wherein said chimeric papilloma virus L1 proteins have the immunogenicity of the L1 proteins of the corresponding HPV types. Said chimeric papilloma virus L proteins have better expression amount and solubility for mass production of vaccines.

Abstract: A method for determining a time-domain resource includes: receiving, by a network node, a first signaling sent by a base station, wherein the first signaling is used to configure at least one time-domain resource, the at least one time-domain resource comprises at least one of: at least one uplink time-domain resource for uplink forwarding or at least one downlink time-domain resource for downlink forwarding; and receiving, by the network node, a second signaling sent by the base station, wherein the second signaling is used to instruct the network node to forward on a first time-domain resource.

Abstract: The present invention provides a mono-p-toluenesulfonate of (S)-(2-((5-chloro-2-((7-(pyrrolidin-1-yl)-6,7,8,9-tetrahydro-5H-benzo[7]annulen-2-yl)amino)pyrimidin-4-yl)amino)-5-(methoxymethyl)phenyl)dimethyl phosphine oxide, and a hydrate and a crystal form thereof. The crystal form of p-toluenesulfonate has a good stability, is easy to process, and has a high solubility.

Abstract: Embodiments of the present application disclose a multi-sensor trigger control method, apparatus and device, and a storage medium, and relate to the technical field of sensors. The method includes: acquiring a target output frequency and an output phase set; determining, according to the output phase set and a preset value, an initial value and an overflow value of a counter corresponding to each phase in the output phase set; calculating a reference frequency according to the overflow value and the target output frequency; detecting, according to a received input signal and an output signal corresponding to the reference frequency, whether a phase alignment condition is met; and if the phase alignment condition is met, performing multi-sensor trigger through a trigger control method according to the overflow value and the initial value. By means of the embodiments of the present application, the trigger moment can be flexibly adjusted.

Abstract: Provided is a self-assembling peptide, a preparation method, the self-assembling peptide formulations and use, and it is related to the field of biotechnology. The self-assembling peptide provided by the present disclosure has a general formula as shown in AC-Pro-X1-X3-X2-X3-X1-X3-X2-Pro-amide. Through experiments, the inventors of the present disclosure found that the self-assembling peptide provided by the present disclosure, because solubility is high and difficulty of synthesis and purification is less compared with a traditional self-assembling peptide, is more feasible for industrial production, and even cheaper to produce. In mass synthesis and purification, the number of purification decreases, the single purification amount increases, the purity of a crude peptide can reach 90% or more, and the cost is greatly reduced.

Abstract: Disclosed is a high strength, high-temperature corrosion resistant martensitic stainless steel characterized by comprising the following chemical elements in percentages by mass: 0<C?0.05%, 0.1-0.2% of Si, 0.20-1.0% of Mn, 11.0-14.0% of Cr, 4.0-6.0% of Ni, 1.5-2.5% of Mo, 0.001%-0.10% of N, 0.03-0.2% of V, 0.01-0.1% of Nb, 0.01-0.04% of Al, and the balance being Fe and inevitable impurities. In addition, also disclosed are tubing and casing manufactured from the above-mentioned high strength, high-temperature corrosion resistant martensitic stainless steel, and a method for manufacturing the tubing and the casing. The high strength, high-temperature corrosion resistant martensitic stainless steel of the present disclosure has an excellent high temperature corrosion resistance to carbon dioxide and chloride ions, as well as excellent low-temperature impact toughness and a high-temperature strength degradation resistance.

Abstract: The present invention discloses a crystal form, a preparation method and an application of a 4?-substituted nucleoside compound I having the following structure, including salts, prodrugs, and compositions thereof. Animal pharmacokinetic studies demonstrated that the effective drug concentrations of Compound Ia and Compound Ig in HIV target cells, peripheral blood mononuclear cells (PBMC), were effective in inhibiting HIV replication after 7 and 5 days, respectively. Therefore, Compound I can be used as a long-acting drug for preventing and treating AIDS. R is selected from ethynyl, azide, and cyano groups, X is selected from hydrogen and fluorine, and B is selected from B1 and B2.

Abstract: A detection device (10), comprising a sample detection layer (1) provided thereon with a detection reagent reacted with an analyte and a result display region (18), wherein the device further comprises a symbol display layer (2) on which an indicator (21) is processed; after the indicator contacts with a gas which can change the color of the indicator, the indicator changes from a first color to a second color.

Abstract: Disclosed is the use of isothiocyanate compounds. In particular, disclosed is the use of a compound as shown by Formula (I) or a derivative as shown by Formula (II) in the manufacture of a composition or preparation for preventing and/or treating hyperlipidemia. The compound of the present invention can reduce the levels of triglycerides and low density lipoproteins in the serum of mammals (such as rats and humans), increase the level of high density lipoproteins in the serum, and reduce the level of total bilirubin in the serum of mammals (such as rats and humans).

Abstract: A 2-(2,4,5-substituted phenylamino) pyrimidine derivative, having the following chemical formula I:

Abstract: The present invention discloses a method for manufacturing a superior 13Cr tool coupler, which method comprises the following steps: manufacturing a blank; forging the blank; heating the forged blank to 600-700° C. for a stress-relief annealing; quenching; and tempering. The present technical solution can produce a superior 13Cr tool coupler which achieves a mechanic feature of 110 ksi.

Abstract: A detection device (10), comprising a sample detection layer (1) provided thereon with a detection reagent reacted with an analyte and a result display region (18), wherein the device further comprises a symbol display layer (2) on which an indicator (21) is processed; after the indicator contacts with a gas which can change the color of the indicator, the indicator changes from a first color to a second color. The present invention also relates to a detection cassette (40) comprising the detection device and a sample detection method capable of visually reading detection results achieved by the detection device.

Abstract: A method for manufacturing a superior 13Cr thickened drillrod comprises the following steps: firstly, thickening the ends of a steel tube with a composition so as to obtain a drillrod with thickened ends, the composition in percentage by weight being: C: 0.01-0.05%, Si?0.5%, Mn: 0.2-1.0%, Cr: 12-14%, Mo: 1-3%, Ni: 4-6%, and a balance of Fe and inevitable impurities; after heating the tube as a whole to 950-1000° C., air cooling same and tempering same at 600-650° C.; and machining the two thickened ends respectively into an externally threaded drillrod coupler and an internally threaded drillrod coupler; wherein the tube end thickening is an external thickening, including three rounds of heating and three rounds of thickening, with at least one pass of deformation for each round, and the heating temperature being 1150-1200° C.

Abstract: Disclosed is the use of isothiocyanate compounds. In particular, disclosed is the use of a compound as shown by Formula (I) or a derivative as shown by Formula (II) in the manufacture of a composition or preparation for preventing and/or treating hyperlipidemia. The compound of the present invention can reduce the levels of triglycerides and low density lipoproteins in the serum of mammals (such as rats and humans), increase the level of high density lipoproteins in the serum, and reduce the level of total bilirubin in the serum of mammals (such as rats and humans).

Abstract: The present invention relates to a combined application of isothiocyanate compounds and anti-cancer drugs, in particular to a composition, comprising: (A) a therapeutically effective amount of a first active ingredient, the first active ingredient being an isothiocyanate compound or derivative thereof; (B) a therapeutically effective amount of a second active ingredient, the second active ingredient being anti-cancer drugs effecting or influencing DNA, kinase inhibitor anti-cancer drugs or endocrine therapy hormonal anti-cancer drugs, the mass ratio of the first active ingredient and the second active ingredient being from 1:10000 to 10000:1. Also disclosed are an active ingredient composition, kit, pharmaceutical composition and uses thereof in the preparation of anti-cancer drugs. The composition, active ingredient composition and kit have excellent effect of inhibiting the growth of cancer cells.

Abstract: The present invention relates to a combined application of isothiocyanate compounds and anti-cancer drugs, in particular to a composition, comprising: (A) a therapeutically effective amount of a first active ingredient, the first active ingredient being an isothiocyanate compound or derivative thereof; (B) a therapeutically effective amount of a second active ingredient, the second active ingredient being anti-cancer drugs effecting or influencing DNA, kinase inhibitor anti-cancer drugs or endocrine therapy hormonal anti-cancer drugs, the mass ratio of the first active ingredient and the second active ingredient being from 1:10000 to 10000:1. Also disclosed are an active ingredient composition, kit, pharmaceutical composition and uses thereof in the preparation of anti-cancer drugs. The composition, active ingredient composition and kit have excellent effect of inhibiting the growth of cancer cells.

Abstract: The present invention discloses a method for manufacturing a superior 13Cr tool coupler, which method comprises the following steps: manufacturing a blank; forging the blank; heating the forged blank to 600-700° C. for a stress-relief annealing; quenching; and tempering. The present technical solution can produce a superior 13Cr tool coupler which achieves a mechanic feature of 110 ksi.

Abstract: A method for manufacturing a superior 13Cr thickened drillrod comprises the following steps: firstly, thickening the ends of a steel tube with a composition so as to obtain a drillrod with thickened ends, the composition in percentage by weight being: C: 0.01-0.05%, Si?0.5%, Mn: 0.2-1.0%, Cr: 12-14%, Mo: 1-3%, Ni: 4-6%, and a balance of Fe and inevitable impurities; after heating the tube as a whole to 950-1000° C., air cooling same and tempering same at 600-650° C.; and machining the two thickened ends respectively into an externally threaded drillrod coupler and an internally threaded drillrod coupler; wherein the tube end thickening is an external thickening, including three rounds of heating and three rounds of thickening, with at least one pass of deformation for each round, and the heating temperature being 1150-1200° C.