Abstract: The disclosure provides a method of active immunotherapy for a cancer patient, comprising administering vaccines against Globo series antigens (i.e., Globo H, SSEA-3 and SSEA-4). Specifically, the method comprises administering Globo H-CRM197 (OBI-833/821) in patients with cancer. The disclosure also provides a method of selecting a cancer patient who is suitable as treatment candidate for immunotherapy. Exemplary immune response can be characterized by reduction of the severity of disease, including but not limited to, prevention of disease, delay in onset of disease, decreased severity of symptoms, decreased morbidity and delayed mortality.

Abstract: A rotary closed-valve vacuum suction device is mounted to a bottom of an object, and has a valve assembly, a sucker, and a valve part. The valve assembly has a top valve seat and a bottom valve seat mounted below the top valve seat. The sucker is mounted to a bottom of the valve assembly. The valve part is inserted through a valve hole of the sucker and the bottom valve seat, and is connected to the top valve seat. When one of the top valve seat and the bottom valve seat is rotated to change the relative position between the bottom valve seat and the top valve seat in a height direction of the valve assembly, the valve part switches the valve hole of the sucker between an open state and a closed state.

Abstract: A rotary closed-valve type vacuum suction device is mounted to a bottom of an object, and has a valve assembly, a sucker, and a valve part. The valve assembly has a top valve seat and a bottom valve seat mounted below the top valve seat. The sucker is mounted to a bottom of the valve assembly. The valve part is inserted through a valve hole of the sucker and the bottom valve seat, and is connected to the top valve seat. When one of the top valve seat and the bottom valve seat is rotated to change the relative position between the bottom valve seat and the top valve seat in a height direction of the valve assembly, the valve part switches the valve hole of the sucker between an open state and a closed state.

Abstract: The present invention provides peptide mimics for GD3 ganglioside. The peptide mimics were identified by panning phage display peptide libraries with an anti-GD3 monoclonal antibody. The peptide mimics inhibit the binding of an anti-GD3 antibody to GD3 positive cells and also elicit antibodies which can bind to GD3 positive cells. The identified peptide mimics can be used as immunogens for cancer therapy.

Abstract: The present invention provides peptide mimics for GD2 ganglioside. The peptide mimics were identified by panning phage display peptide libraries with an anti-GD2 monoclonal antibody. The identified peptide mimics can be used as immunogens for cancer therapy such as for melanoma and neuroblastoma.