Abstract: Provided is an anesthetic composition for locally administering a local anesthetic agent to a subject in need thereof. The anesthetic composition has a lipid based complex prepared by hydrating a lipid cake containing a local anesthetic agent and a lipid mixture with an aqueous buffer solution at a pH higher than 5.5. Also provided is a method to prepare an anesthetic composition using a simpler and more robust for large-scale manufacture and for providing a high molar ratio of local anesthetic agent to phospholipid content as compared to the prior art. This anesthetic composition has a prolonged duration of efficacy adapted to drug delivery.

Abstract: A speaker device with a processing unit and a storage device for controlling the operation of the speaker device also has a speaker unit and a connection module. The processing unit adjusts the speaker unit to operate in a first sound mode based on the first frequency characteristic of the speaker unit, and detects whether the connection module is communicatively coupled with a sound device having a second frequency characteristic. The processing unit switches the speaker unit from the first sound mode into a second sound mode based on the comparison between the first frequency characteristic and the second frequency characteristic.

Abstract: A speaker device with a processing unit and a storage device for controlling the operation of the speaker device also has a speaker unit and a connection module. The processing unit adjusts the speaker unit to operate in a first sound mode based on the first frequency characteristic of the speaker unit, and detects whether the connection module is communicatively coupled with a sound device having a second frequency characteristic. The processing unit switches the speaker unit from the first sound mode into a second sound mode based on the comparison between the first frequency characteristic and the second frequency characteristic.