Abstract: The present invention relates to antagonist antibodies that specifically bind to Notch 3 and inhibit its activation. The present invention includes antibodies binding to a conformational epitope comprising the first Lin12 domain and the second dimerization domain. The present invention also includes uses of these antibodies to treat or prevent Notch 3 related diseases or disorders.

Abstract: The present invention relates to novel antibodies that bind specifically to human Notch 3 and their use in the detection and/or diagnosis of Notch 3 related diseases, such as cancer. The present invention also includes nucleic acids encoding these novel antibodies, vectors and cell lines harboring the nucleic acids, and kits comprising the antibodies for use in the detection and diagnosis.

Abstract: The present invention relates to agonist antibodies that specifically bind to Notch 3 and activate signaling. The present invention includes antibodies binding to an epitope comprising the first Lin12 domain. The present invention also includes uses of these antibodies to treat or prevent Notch 3 related diseases or disorders.

Abstract: The invention relates to humanized anti-human Factor D monoclonal antibodies, their nucleic acid and amino acid sequences, the cells and vectors that harbor these antibodies and their use in the preparation of compositions and medicaments for treatment of diseases and disorders associated with excessive or uncontrolled complement activation. These antibodies are useful for diagnostics, prophylaxis and treatment of disease.

Abstract: Systems and methods for rearranging valid data within a block of data for transmission along a data path are described herein. By utilizing previously unused bits in data words, the valid data can be transmitted in fewer clock cycles, thereby increasing the availability of the data bus to other masters. An exemplary embodiment of a system for transmitting data along a data bus includes one or more masters, one or more slaves, and a data bus interconnecting the masters and slaves. One of the slaves is a memory controller configured to access data from an external memory device. The memory controller may be further configured to pack video data for transmission along the data bus. One of the masters is a video display controller configured to feed video data to an external video display. The video display controller may be further configured to receive the packed video data and unpack the packed video data for transmission to the video display.

Abstract: Systems and methods are disclosed herein for controlling the way in which data access requests from different masters are handled. In one example, a memory controller comprises a request analyzer configured to receive a data access request via a data bus. The request analyzer is further configured to analyze the request to determine the identity of a master making the request. The memory controller also includes a buffer system configured to store data and a controller device configured to control how data is stored in the buffer system. The controller device controls data storage within the buffer system based on the identity of the master making the request. Generally, the memory controller may operate by transmitting a first data block in response to a request thereto and pre-fetching a second data block in anticipation of the second data block being requested on a next data access request.

Abstract: Systems and methods for compressing data within a block of data for storage in memory and for transmission along a data path are described herein. By utilizing previously unused bits in data words, the valid data can be stored more efficiently and transmitted in fewer transfer cycles, thereby increasing the availability of the data bus to other masters. One embodiment of a system for storing and transmitting compressed data includes masters and slaves interconnected by a data bus. One of the masters is a video input interface configured to receive video data from an external video source. The video input interface is further configured to compress the video data using a compression algorithm based on the difference in color between two adjacent pixels. Another one of the masters is a video display controller configured to receive the compressed video data.

Abstract: The present invention relates to the treatment of IL13 dependent neoplastic disorders comprising the administration of novel anti-IL13 antibodies, The invention also includes diagnosing such tumors or cancer using the antibodies of the present invention to detect overexpression of IL13 in the patient.

Abstract: A food processor bowl includes a container having a coaxial inner sleeve for locating a rotary tool in the container and a dispensing opening. A removable closure for the container has an open position for dispensing contents from the container and a closed position for defining a processing chamber in the container. A support extends across the dispensing opening and has a central hub for retaining a rotary tool within the container when contents of the container are being dispensed through the dispensing opening.

Abstract: A transaction system (10) for use by users, comprising: electronic tokens (24) for storing and processing token transaction data (28) and token reward data (30), each for use by a respective user; a computer server (12) for storing and processing server transaction data (32) and server reward data (18) associated with each of the tokens (24); and user interaction devices (14,16) for communicating with the server (12), at least one of which (14) having a token acceptor device (15) for reading from and writing to the tokens (24); wherein the transaction data (28,32) are indicative of at least one transaction and the reward data (30,18) are indicative of earned rewards, the system (10) being operable to transfer server reward data (18) to a respective token (24) and token reward data (30) to the server (12) by means of the user interaction device (14) provided with a token acceptor device (15), so that rewards are redeemable according to reward data (30) on the token (24) or reward data (18) stored on the server

Abstract: Provided are a method, system and program for considering remote end point performance to select a remote end point to use to transmit a task. A maximum outstanding tasks and a current outstanding tasks comprising a number of outstanding tasks transmitted over a network are provided. A task is received to transmit over the network. A determination is made as to whether the current outstanding tasks is less than the maximum outstanding tasks. The received task is transmitted over the network in response to determining that the current outstanding tasks is less than the maximum outstanding tasks.

Abstract: A hot and cold beverage maker has a housing having a base and an upper body. A water reservoir, brew basket and water heater are located in the housing. There is a water passage from the reservoir thorough the water heater to the brew basket for delivering heated water to the brew basket. In the base is a cradle for supporting a beverage jug beneath the brew basket outlet. The cradle has a rotary coupling for engaging a corresponding coupling of a beverage jug placed in the cradle. The beverage maker may also include a beverage jug having a base with a rotary blade in the jug connected to a jug coupling at the jug base.

Abstract: Provided are a method, system, and program monitoring paths between a first controller and second controller. A determination is made as to whether one path has been unavailable for a predetermined time period in response to detecting that the path is unavailable. Indication is made that the path is in a first failed state if the path has been unavailable for more than the predetermined time period and indication is made that the path is in a second failed state if the path has not been unavailable for the predetermined time period.

Abstract: A pseudo-synchronous temporary storage element transports data between two system blocks with different clock systems by pseudo-synchronizing the clock edges of the two clock signals. The pseudo-synchronization circuit may be an integral part of a storage element, a separate pseudo-synchronization device, or a discrete add-on circuit to an off the shelf storage element device.

Abstract: A vacuum coffee maker comprises a first vessel for receiving water to be heated and brewed coffee and a second vessel for receiving coffee grounds and brewing coffee therein. The first vessel has an opening in it and a fluid passage from the opening to a lower potion of the vessel. The second vessel having an opening in it. A base for receiving the first vessel is provided with a heater. A platform supports the second vessel above the first vessel. Engagement means releasably brings together the opening in the first vessel and the opening in the second vessel for fluid communication between the first and second vessels.

Abstract: A method of making coffee in a drip-type coffee maker includes introducing steam into coffee grounds, and passing heated water through the coffee grounds to infuse the water. A coffee maker includes a second water passage in which the flow of water is controlled so that it is converted into steam for delivery to the brew basket. The steam enters the brew basket below the level of any coffee grinds in the basket, and causes a substantially helical steam flow path in the grinds.

Abstract: A method of making coffee in a drip-type coffee maker includes adding heated water to a brew basket containing coffee grinds, allowing said water to accumulate within the brew basket, and at a predetermined moment opening an aperture in the brew basket to allow the water to drain. In a drip-type coffee maker the aperture in the brew basket has a closure. A controller is operable to move the aperture closure to the open position a predetermined moment after heated water is delivered to the brew basket. The predetermined moment may be when the water in the brew basket reaches a predetermined level, or a predetermined time after the coffee maker is activated.

Abstract: An electric hand mixer comprises a housing and a motor mounted with the housing. A gearbox is mounted with the housing and coupled with an output shaft of the motor. A pair of spindles having respective axes are positioned about a shared axis. The spindles are coupled with the gearbox for rotation about the respective axes and rotation about said third axis.

Abstract: A method to provide information from a first information storage and retrieval system to a second information storage and retrieval system, where the first information storage and retrieval system comprises (N) PPRC adapters and information. The method generates and saves an Established Path Bitmap which recites the (N) PPRC adapters, and generates an Available Path Bitmap. If a PPRC adapter is in communication with the secondary storage system, then the method adds that adapter to the Available Path Bitmap. The primary information storage and retrieval system generates a PPRC task comprising a flag set to “off”. The method copies the Available Path Bitmap as a Working Bitmap, and generates a PPRC request comprising a flag set to “on”, selects one of the adapters recited in the Working Bitmap, and provides the PPRC request to that selected adapter. The method then once attempts to provide information to the second information storage and retrieval system using the selected adapter.

Abstract: Provided are a method, system, and program for copying tracks between a primary controller and secondary controller. A track is received from the primary controller that is part of a copy job comprising a sequence of tracks to copy along with a sequence number of the received track and a context number identifying computational resources in the primary controller used to transmit the track, sequence number, and context number. The context number and sequence number transmitted with the track are used to determine if a track preceding the received track was written to storage. The secondary-controller writes the received track to storage if the track preceding the received track was written to storage.