Abstract: Method of inhibiting a protein-protein interaction between Von Hippel-Lindau tumor-suppressor protein and hypoxia-inducible factor 1-alpha useful in the treatment of angiogenesis-related diseases and promoting wound healing.

Abstract: A tool that is either hand-guided, or machine-guided, for performing surface treatments, such as mopping, of overhead surfaces includes a head for carrying an agitator having a generally planar face that is applied against the overhead surface being treated in uses. A transmission transmits power from a drive motor to the agitator, and an interface on the head is provided for connection to a mounting device by which the head is oriented and guided.

Abstract: Method of inhibiting a protein-protein interaction between Von Hippel-Lindau tumor-suppressor protein and hypoxia-inducible factor 1-alpha useful in the treatment of angiogenesis-related diseases and promoting wound healing.

Abstract: A tool that is either hand-guided, or machine-guided, for performing surface treatments, such as mopping, of overhead surfaces includes a head for carrying an agitator having a generally planar face that is applied against the overhead surface being treated in uses. A transmission transmits power from a drive motor to the agitator, and an interface on the head is provided for connection to a mounting device by which the head is oriented and guided.

Abstract: A baggage management system includes: a storage rack including a plurality of receptacles shaped and structured to retain one or more baggage items; a baggage transportation system including a plurality of automated guided vehicles (AGVs) configured to transport one or more baggage items between a pick up point, a drop off point, and the storage rack, each AGV including a a wireless communication unit and a controller configured to control movement of the specific AGV based on received control instructions; and a baggage administration server including a processor, a memory unit, and a wireless communication interface, and configured to receive a request to store or retrieve a baggage item from the storage rack, determine the position of the one or more AGVs, identify the one or more AGVs required to either store or retrieve a baggage item as defined in the request, and transmit control instructions to the AGVs.

Abstract: An autonomous guided vehicle comprising a platform adapted to carry a load thereon in a working position; a plurality of suspension devices connected to the platform, each suspension device having a sensor and an actuator; and a plurality of wheels associated with the suspension devices; wherein a first wheel is associated with a first suspension device such that the sensor of the first suspension device is adapted to provide a signal when a relative position of the first wheel and the platform is altered.

Abstract: An autonomous guided vehicle comprising a platform adapted to carry load thereon in a working position; a plurality of suspension devices connected to the platform, each suspension device having a sensor and an actuator; and a plurality of wheels associated with the suspension devices; wherein a first wheel is associated with a first suspension device such that the sensor of the first suspension device is adapted to provide a sign when a relative position of the first wheel and the platform is altered.

Abstract: An apparatus or system for reinforcement bar (rebar) joint recognition using artificial intelligence vision includes a rebar tying tool attached to a micro manipulator; and a macro manipulator for moving the position of the micro manipulator; wherein the macro manipulator is adapted to move the micro manipulator on a first plane; the micro manipulator is adapted to move the rebar tying tool on a second plane parallel to the first plane and at a first axis vertical to the second plane.

Abstract: An apparatus or system for reinforcement bar (rebar) joint recognition using artificial intelligence vision includes a rebar tying tool attached to a micro manipulator; and a macro manipulator for moving the position of the micro manipulator; wherein the macro manipulator is adapted to move the micro manipulator on a first plane; the micro manipulator is adapted to move the rebar tying tool on a second plane parallel to the first plane and at a first axis vertical to the second plane.

Abstract: A luminescent Ir(III) complex is used to develop a label-free G-quadruplex-based assay for lead ions in liquid or solution. In particular, the present invention describes method for monitoring lead ion concentration in water.

Abstract: A luminescent Ir(III) complex it used to develop a label-free G-quadruplex-based assay for lead ions in a liquid or aqueous solution. In particular, the present invention describes method for monitoring lead ion concentration in water.

Abstract: Bromodomain-containing protein 4 (BRI)) has recently emerged as an attractive epigenetic target for anticancer therapy. Iridium(III) complexes are useful as irreversible inhibitor of BRD4. Complex 1a of the formula: is particularly useful.

Abstract: The present invention provides a method of detecting helicase activity in a test solution, providing a substrate solution containing a double-stranded DNA, wherein said double-stranded DNA is a substrate for a helicase to be detected; (b) introducing the substrate solution to the test solution to form a reaction solution; (c) applying a luminescent probe into the reaction solution to form a mixture; and (d) measuring a luminescent response of the luminescent probe in the mixture, wherein the luminescent response corresponds to the helicase activity in the test solution. The present invention also refers to a method of screening a potent luminescent probe for detecting helicase activity, and a series of luminescent Ir (III) complexes.

Abstract: A compound of the formula: Also, a method for antagonizing STAT3 dimerization in a patient in need thereof which by administering to such patient a therapeutically acceptable dose of the compound of Formula I. Further, a method for treating a cancer patient in need thereof by administering a therapeutically effective dose of the compound of Formula I.

Abstract: A luminescent Ir(III) complex it used to develop a label-free G-quadruplex-based assay for lead ions in a liquid or aqueous solution. In particular, the present invention describes method for monitoring lead ion concentration in water.

Abstract: A luminescent Ir(III) complex is used to develop a label-free G-quadruplex-based assay for lead ions in liquid or solution. In particular, the present invention describes method for monitoring lead ion concentration in water.

Abstract: A compound of the formula: Also, a method for antagonizing STAT3 dimerization in a patient in need thereof which by administering to such patient a therapeutically acceptable dose of the compound of Formula I. Further, a method for treating a cancer patient in need thereof by administering a therapeutically effective dose of the compound of Formula I.

Abstract: The present invention is a wrist massager particularly applying to the wrist part of human being adopting acupressure theory of Traditional Chinese Medicine (TCM) in order to circumvent wrist musculoskeletal disorders (MSDs). It comprises a wrist band operably engaged a control panel 4 and a motorised cushion housing 2 with protruding massage means3. The wrist band added with size-adjustable mechanism is designed for users to fit their wrist into the massager comfortably and firmly. It contains a motor/motors to produce vibration and deliver reciprocating and/or rotary massaging effect via the massage means3. Alternatively, the wrist massager is a plate 8 with planar bottom and a housing placed on the surface of the plate 8. A detachable massaging means protrudes from the surface of the said housing.

Abstract: The present invention relates to an acupressure pen and methods of acupressure treatment, wherein said pen is capable of determining the optimal range for treatment on a particular acupoint, and recalling such optimal range during subsequent treatments. Through the use of a grid system, infrared communicator, and microcontroller, the pen is capable of being set and storing results in a matrix.