Abstract: The present invention provides a conjugate comprising: (a) a CNS-targeting ligand, (b) a hydrophilic polymer of polyethylene glycol (PEG), polylactic acid (PLA), polylactic-co-glycolic acid (PLGA), or dextran, and (c) a flavonoid. The present invention also provides to a micelle nanoparticle composition comprising: (a) an outer shell comprising the conjugate, optionally (b) an inner shell comprising oligomeric (?)-epigallocatechin gallate (OEGCG), and optionally (c) a CNS disease-treating molecule encapsulated in the inner shell. The present invention further provides a method for treating a CNS disease by administering an effective amount of the present nanoparticle composition to a subject. The CNS-targeting ligand targets the CNS tissue and delivers active ingredients to CNS tissue for treating the CNS pathogenic conditions.

Abstract: The present invention provides a conjugate comprising: (a) a cardiovascular disease (CVD)-targeting ligand, (b) a hydrophilic polymer of polyethylene glycol (PEG), polylactic acid (PLA), polylactic-co-glycolic acid (PLGA), or dextran, and (c) a flavonoid. The present invention also provides to a micelle nanoparticle composition comprising: (a) an outer shell comprising the conjugate, optionally (b) an inner shell comprising oligomeric (?)-epigallocatechin gallate (OEGCG), and optionally (c) a CVD-treating molecule encapsulated in the inner shell. The present invention further provides a method for treating a CVD by administering an effective amount of the present nanoparticle composition to a subject. The CVD-targeting ligand targets the heart tissue and delivers active ingredients to heart tissue for treating cardiovascular diseases or conditions.

Abstract: The present invention provides a method of treating an infectious disease. The method comprises the step of administering to a subject in need thereof an effective amount of (i) a polymer-flavonoid conjugate, (ii) a flavonoid oligomer, or (iii) micelles having a shell formed by one or more polymer-flavonoid conjugates or one or more flavonoid oligomers, or the combination thereof, and having an agent encapsulated within the shell. The present method is effective to treat viral infection, e.g., severe acute respiratory syndrome coronavirus (SARS-CoV), enterovirus virus, HIV, hepatitis B virus, MERS-CoV, influenza virus, Dengue virus, respiratory syncytial virus, hepatitis C virus, monkeypox virus, human papillomavirus, methicillin-resistant Staphylococcus aureus, Pseudomonas, tuberculosis, Bacillus anthracis, Tetani bacterium, Streptococcus pneumoniae, meningococcus, Escherichia coli, Legionella, Neisseria gonorrhea, Neisseria meningitidis, and Salmonella.

Abstract: The present invention provides a method of treating an autoimmune disease including type 1 diabetes, inflammatory bowel disease, rheumatoid arthritis. multiple sclerosis, systemic lupus erythematosus, psoriasis, myasthenia Gravis, and Hashimoto's thyroiditis. The method comprises the step of administering to a subject in need thereof an effective amount of micelles having an outer shell comprising one or more polymer-flavonoid conjugates, optionally an inner shell comprising one or more flavonoid oligomer, and a drug encapsulated within the shells. The present invention also provides a method of treating an autoimmune disease by administering to a subject in need thereof an effective amount of one or more polymer-flavonoid conjugate or one or more flavonoid oligomers.

Abstract: The present invention provides a conjugate comprising: (a) a cancer-targeting ligand, (b) a hydrophilic polymer of polyethylene glycol (PEG), polylactic acid (PLA), polylactic-co-glycolic acid (PLGA), or dextran, and (c) a flavonoid. The present invention also provides to a micelle nanoparticle composition comprising: (a) an outer shell comprising the conjugate, (b) an inner shell comprising oligomeric (?)-epigallocatechin gallate (OEGCG), and optionally (c) a cancer-treating molecule encapsulated in the inner shell. In one embodiment, the nanoparticle composition has at least 70% of the nanoparticles with a diameter between 20-500 nm or 50-300 nm, and one single major peak in the size distribution. The present invention further provides a method for treating cancer by administering an effective amount of the present nanoparticle composition to a subject. The cancer-targeting ligand targets the tumor and delivers active ingredients to tumor for treating cancer.

Abstract: Systems and methods for operating a quantum processor. The methods comprise: training one or more quantum neural networks using modulation class data to make decisions as to a modulation classification for a signal based on one or more feature inputs for the signal; obtaining, by the quantum processor, principle components of real and imaginary components of a signal received by a communication device; and performing first quantum neural network operations by the quantum processor using the principle components as inputs to the trained one or more quantum neural networks to generate a plurality of scores, wherein each said score represents a likelihood that the received signal was modulated using a given modulation type of a plurality of different modulation types.

Abstract: The present invention provides a method of preventing or treating CNS diseases. The method comprises the step of administering to a subject in need thereof an effective amount of (i) a polymer-flavonoid conjugate, (ii) a flavonoid oligomer, or (iii) micelles having an outer shell comprising one or more polymer-flavonoid conjugates and optionally an inner shell comprising one or more flavonoid oligomer and a drug encapsulated within the shells. The present method brings therapeutic effective materials through blood-brain barrier to treat CNS diseases. The present method is effective to treat CNS diseases such as brain tumors, stroke, neurodegenerative diseases.

Abstract: Systems and methods for operating a communication device. The methods comprise: receiving a signal at the communication device; performing, by the communication device, one or more machine learning algorithms using at least one feature of the signal as an input to generate a plurality of scores (each score representing a likelihood that the signal was modulated using a given modulation type of a plurality of different modulation types); assigning a modulation class to the signal based on the plurality of scores; determining whether a given wireless channel is available based at least on the modulation class assigned to the signal; and selectively using the given wireless channel for communicating signals based on results of the determining.

Abstract: Improved methods and systems for personal medical monitoring are disclosed. The monitoring yields status information pertaining to persons being monitored. Notifications, recommendations and/or actions can be initiated by examination or analysis of the status information. The status information can include health, position (location) and other information.

Abstract: A rate-sensitive protective apparel including an outer fabric shell, first and second sealing material layers positioned within the outer fabric shell, and a shear thickening fluid core disposed between the first and second sealing material layers is provided. The sealing material layers have fibers extending towards the apparel interior and enmeshing the shear thickening fluid core, and the shear thickening fluid directly contacts with the sealing material and the fibers.

Abstract: An impact dissipating bollard system includes a vertical stanchion and a composite energy-absorbing deformable cartridge configured to be positioned within a retaining foundation that includes a rigid core portion including a stanchion-receiving aperture and first and second projections extending from the rigid core portion. The first and second projections, together with the core portion, form the dumbbell shape. Energy-absorbing resilient elastic material surrounds the rigid core portion and is positioned within recesses within the first and second projections. The bollard system is configured such that impact energy is transferred from the vertical stanchion to deform the composite energy-absorbing deformable cartridge. The bollard system retaining foundation includes a reinforcing frame embedded in concrete and having a strength of least 30 MPa.

Abstract: Systems and methods for operating a communication device. The methods comprise: receiving a signal at the communication device; performing, by the communication device, one or more machine learning algorithms using at least one feature of the signal as an input to generate a plurality of scores (each score representing a likelihood that the signal was modulated using a given modulation type of a plurality of different modulation types); assigning a modulation class to the signal based on the plurality of scores; determining whether a given wireless channel is available based at least on the modulation class assigned to the signal; and selectively using the given wireless channel for communicating signals based on results of the determining.

Abstract: A CO2 sequestration system sequesters carbon dioxide as carbon dioxide hydrate in offshore saline aquifers. The system includes an offshore aquifer in a tropical region. A plurality of wellbores are positioned inside or around a perimeter of the aquifer. The CO2 may be injected into the aquifer via separate injectors located in the wellbores connected to the aquifer while aquifer water or brine is produced from one or more of the other wellbores and provided to the aquifer. Injection of the CO2 into and production of water from the offshore aquifer at separately timed intervals may maintain the reservoir pressure below the reservoir fracture pressure and the hydrate formation pressure so that the CO2 may be stored as carbon dioxide hydrate within the aquifer. Depending on the specific output desired, the aquifer may be positioned either straddling or within a hydrate stability zone. A method for sequestering CO2 uses the aforementioned system to carry out CO2 sequestration.

Abstract: A method for storing CO2 includes identifying a depleted or partially depleted gas, gas condensate or oil reservoir having a plurality of injection wells and a plurality of production wells. The reservoir is then depleted. Once the reservoir is depleted or partially depleted, enhanced oil recovery and/or enhanced gas recovery is then performed on the reservoir where a first quantity of carbon dioxide is injected into the plurality of injection wells to displace the remaining oil and gas. Heat mining is then performed on the reservoir, where the second quantity of carbon dioxide is injected into the reservoir and the first and second quantities of carbon dioxide are subsequently produced to the surface for capture and conversion of geothermal heat of the first and second quantities of carbon dioxide into electricity. A third quantity of carbon dioxide is then injected and stored in the reservoir permanently.

Abstract: A CO2 sequestration system sequesters carbon dioxide as carbon dioxide hydrate in offshore saline aquifers. The system includes an offshore aquifer in a tropical region. A plurality of wellbores are positioned inside or around a perimeter of the aquifer. The CO2 may be injected into the aquifer via separate injectors located in the wellbores connected to the aquifer while aquifer water or brine is produced from one or more of the other wellbores and provided to the aquifer. Injection of the CO2 into and production of water from the offshore aquifer at separately timed intervals may maintain the reservoir pressure below the reservoir fracture pressure and the hydrate formation pressure so that the CO2 may be stored as carbon dioxide hydrate within the aquifer. Depending on the specific output desired, the aquifer may be positioned either straddling or within a hydrate stability zone. A method for sequestering CO2 uses the aforementioned system to carry out CO2 sequestration.

Abstract: Systems and methods for operating a communication device. The methods comprise: receiving a signal at the communication device; performing, by the communication device, one or more machine learning algorithms using at least one feature of the signal as an input to generate a plurality of scores (each score representing a likelihood that the signal was modulated using a given modulation type of a plurality of different modulation types); assigning a modulation class to the signal based on the plurality of scores; determining whether a given wireless channel is available based at least on the modulation class assigned to the signal; and selectively using the given wireless channel for communicating signals based on results of the determining.

Abstract: A transmission line for conveying a radio frequency (RF) signal between a first terminal and a second terminal. The transmission line comprises an inner conductor, a middle conductor and an outer conductor. The inner conductor comprises a length of conductive material having a first end for electrical connection with the first terminal and a second end for electrical connection with the second terminal. The middle conductor surrounds at least a part of the length of the inner conductor and is electrically connected to the electrical ground of the source. The outer conductor surrounds at least a part of the length of the middle conductor and is electrically connected to the electrical ground of the load.

Abstract: According to one embodiment, a transceiver includes: a radio transmitter including a power amplifier; a detector circuit including: a squaring circuit configured to receive an output of the power amplifier of the radio transmitter and configured to produce an output current; and a DC current absorber electrically connected to an output terminal of the squaring circuit.

Abstract: Systems and methods for operating a receiver. The methods comprise: receiving, at the receiver, a combined waveform comprising a combination of a desired signal and an interference signal; and performing, by the receiver, demodulation operations to extract the desired signal from the combined waveform. The demodulation operations comprise: obtaining, by the receiver, machine learned models for recovering the desired signal from combined waveforms; comparing, by the receiver, at least one characteristic of the received combined waveform to at least one of the machine learned models; and determining a value for at least one symbol of the desired signal based on results of the comparing.

Abstract: Systems and methods for operating a communication device. The methods comprise: receiving a signal at the communication device; performing, by the communication device, one or more machine learning algorithms using at least one feature of the signal as an input to generate a plurality of scores (each score representing a likelihood that the signal was modulated using a given modulation type of a plurality of different modulation types); assigning a modulation class to the signal based on the plurality of scores; determining whether a given wireless channel is available based at least on the modulation class assigned to the signal; and selectively using the given wireless channel for communicating signals based on results of the determining.