Abstract: Dual-band satellite communication systems and methods are described. A dual-band satellite communication system is described with an array of feeds. The array includes single band feeds and one or more multi-band feeds. The multi-band feeds provide dual-band spot beams. Dual-band spot beams include a first frequency band spot beam and a second frequency band spot beam. A spot beam layout may be provided when a shared reflector for the array of feeds is provided. The first frequency band beamwidth may be smaller than a second frequency band beamwidth and the number of multi-band feeds in the array of feeds may be less than the number of single band feeds.

Abstract: The present disclosure relates to arginase albumin binding domain (ABD) fusion proteins and methods of preparation and use thereof. Also provided are methods involving arginine depletion for the treatment of obesity, metabolic disorders, and related complications and comorbidities.

Abstract: The present invention resides in the discovery that combined use of kuraridin (or any one of its analogs) and epicatechin gallate (ECG) can provide heightened level of antimicrobial activity, especially for the suppression of bacteria of the Staphylococcus aureus and Staphylococcal species. Compositions, kits, and methods for the combination use are disclosed.

Abstract: A high throughput satellite and a method of operating a high throughput satellite. The satellite has multiple modes of operation and transitions between them in response to the spectrum fill rate. Modes of operation may include altering color re-use patterns to increase or reduce number of colors, using intra-beam geographic sub-division, or precoding downlink signals.

Abstract: A high throughput satellite and a method of operating a high throughput satellite. The satellite has multiple modes of operation and transitions between them in response to the spectrum fill rate. Modes of operation may include altering color re-use patterns to increase or reduce number of colors, using intra-beam geographic sub-division, or precoding downlink signals.

Abstract: A membrane electrode assembly including: an anode electrode; a cathode electrode; and a polymer electrolyte membrane; wherein the cathode includes a first cathode catalyst sublayer including a first precious metal catalyst composition and a first ionomer composition including a first ionomer and a second ionomer; and a second cathode catalyst sublayer including a second precious metal catalyst composition and a second ionomer composition including a third ionomer; wherein the first ionomer is different from the second ionomer in at least one of chemical structure and equivalent weight.

Abstract: A high throughput satellite (HTS) and a method of operating the HTS for relaying data between a low earth orbit (LEO) satellite and a target ground station, where the HTS provides spot beams for a spot beam coverage area. The method of operating the HTS includes: determining an estimated trajectory of an orbiting LEO satellite; assigning a plurality of assigned spot beams having a matching color re-use polarization; and transmitting assignments of the plurality of assigned spot beams to the high throughput satellite to cause the high throughput satellite to maintain the inter-satellite link via a first spot beam and one or more assigned subsequent spot beams having the matching color re-use polarization.

Abstract: A high throughput satellite (HTS) and a method of operating the HTS for relaying data between a low earth orbit (LEO) satellite and a target ground station, where the HTS provides spot beams for a spot beam coverage area. The method of operating the HTS includes: determining an estimated trajectory of an orbiting LEO satellite; assigning a plurality of assigned spot beams having a matching color re-use polarization; and transmitting assignments of the plurality of assigned spot beams to the high throughput satellite to cause the high throughput satellite to maintain the inter-satellite link via a first spot beam and one or more assigned subsequent spot beams having the matching color re-use polarization.

Abstract: A geolocation method and system for locating the source of interference to a high throughput satellite. The method involves determining relative power level differences between interference signals received by the victim spot beam and co-colored nearby spot beams on the same satellite. Using beam pattern data, the relative power levels for a pair of beams determines contour lines of possible location the correspond to the relative power difference in the signals received by the two beams in the pair. A point of intersection of contour lines from multiple pairs of spot beams indicates the location of the source of interference.

Abstract: A device for use in pressure sensing such as hydrocephalus shunts, having a housing enclosing a chamber with at least one port communicating with the chamber. A wall of the chamber includes a flexible portion or thin diaphragm that deflects with transitions in pressure to contact an upstand structure of the housing. A pressure sensor is contained within an enclosure sealed from the chamber by a flexible membrane and which receives fluid pressure from the chamber. This arrangement allows for calibration of the device by identifying a knee feature in pressure data associated with the diaphragm making contact with the upstand.

Abstract: Satellite communication methods and payloads are described. An imbalance in uplink and downlink availability may be mitigated through digitizing uplink spectrum, extracting guard band channels, and grouping the guard band channels to create a composite channel. The composite channel is converted to analog and RF up-converted, amplified, and multiplexed with other downlink analog channels before being transmitted to Earth. The guard bands may be from the same band of spectrum or different bands of spectrum, such as C band, Ka band, Ku band, etc. A satellite payload is described with dual output multiplexers having partially overlapping channels and a dual feed configuration. In one downlink implementation, unused regional band spectrum may be dynamically allocated to a spot beam. In one uplink implementation, regional band spectrum may be shared by a spot beam using spatial separation of the regional uplink location from the spot beam coverage area and digital cancellation techniques.

Abstract: Dual-band satellite communication systems and methods are described. A dual-band satellite communication system is described with an array of feeds. The array includes single band feeds and one or more multi-band feeds. The multi-band feeds provide dual-band spot beams. Dual-band spot beams include a first frequency band spot beam and a second frequency band spot beam. A spot beam layout may be provided when a shared reflector for the array of feeds is provided. The first frequency band beamwidth may be smaller than a second frequency band beamwidth and the number of multi-band feeds in the array of feeds may be less than the number of single band feeds.

Abstract: The present application discloses an improved transportation matching system, and corresponding methods and computer-readable media. According to disclosed embodiments, a transportation matching system receives session information from a requestor computing device in response to one or more session events. The system utilizes the received session information to determine a likelihood that the associated session on the requestor computing device will result in a transportation request. If the determined likelihood is above a threshold amount, the system generates an upfront dispatch that matches the associated session to a provider computing device. The system then reserves the provider computing device and generates a predicted dispatch for the reserved provider computing device.

Abstract: A high throughput satellite and a method of operating a high throughput satellite. The satellite has multiple modes of operation and transitions between them in response to the spectrum fill rate. Modes of operation may include altering color re-use patterns to increase or reduce number of colors, using intra-beam geographic sub-division, or precoding downlink signals.

Abstract: Dual-band satellite communication systems and methods are described. A dual-band satellite communication system is described with an array of feeds. The array includes single band feeds and one or more multi-band feeds. The multi-band feeds provide dual-band spot beams. Dual-band spot beams include a first frequency band spot beam and a second frequency band spot beam. A spot beam layout may be provided when a shared reflector for the array of feeds is provided. The first frequency band beamwidth may be smaller than a second frequency band beamwidth and the number of multi-band feeds in the array of feeds may be less than the number of single band feeds.

Abstract: Satellite communication methods and payloads are described. An imbalance in uplink and downlink availability may be mitigated through digitizing uplink spectrum, extracting guard band channels, and grouping the guard band channels to create a composite channel. The composite channel is converted to analog and RF up-converted, amplified, and multiplexed with other downlink analog channels before being transmitted to Earth. The guard bands may be from the same band of spectrum or different bands of spectrum, such as C band, Ka band, Ku band, etc. A satellite payload is described with dual output multiplexers having partially overlapping channels and a dual feed configuration. In one downlink implementation, unused regional band spectrum may be dynamically allocated to a spot beam. In one uplink implementation, regional band spectrum may be shared by a spot beam using spatial separation of the regional uplink location from the spot beam coverage area and digital cancellation techniques.

Abstract: Dual-band satellite communication systems and methods are described. A dual-band satellite communication system is described with an array of feeds. The array includes single band feeds and one or more multi-band feeds. The multi-band feeds provide dual-band spot beams. Dual-band spot beams include a first frequency band spot beam and a second frequency band spot beam. A spot beam layout may be provided when a shared reflector for the array of feeds is provided. The first frequency band beamwidth may be smaller than a second frequency band beamwidth and the number of multi-band feeds in the array of feeds may be less than the number of single band feeds.

Abstract: The present invention provides a pharmaceutical composition containing albumin-binding arginine deiminase (AAD) fusion protein for treating cancer or other arginine-dependent diseases. The AAD fusion protein can be purified from both soluble and insoluble fractions of crude proteins, binds to human serum albumin (HSA) or animal serum albumin and has its high activity with longer half life for efficient depletion of arginine in cancer cells. The specific activities of wild-type ADI and AAD fusion protein in the present invention are about 20 and about 19 U/mg (at physiological pH 7.4), respectively. The composition can be used alone or in combination with at least one chemotherapeutic agent to give a synergistic effect on cancer treatment and/or inhibiting metastasis. The AAD fusion protein can also be used as a component for detection and quantitative analysis of arginine in a testing kit for various samples including blood, food and analytical samples.

Abstract: Homogeneous preparations of human and murine IL-31 have been produced by mutating one or more of the cysteine residues in the polynucleotide sequences encoding the mature proteins. The cysteine mutant proteins can be shown to either bind to their cognate receptor or exhibit biological activity.

Abstract: The present invention provides a pharmaceutical composition containing albumin-binding arginine deiminase fusion protein (AAD) for treating cancer or other arginine-dependent diseases. The AAD fission protein can be purified from both soluble and insoluble fractions of crude proteins, it binds to human serum albumin (HSA) and has its high activity with longer half life for efficient depletion of arginine in cancer cells. The specific activities of wild-type ADI and AAD in the present invention are 8.4 and 9.2 U/mg (at physiological pH 7.4), respectively. The AAD used in the present invention can be used in the treatment of various cancers (e.g. pancreatic cancer, leukemia, head and neck cancer, colorectal cancer, lung cancer, breast cancer, liver cancer, nasopharyngeal cancer, esophageal cancer, prostate cancer, stomach cancer & brain cancer) and curing arginine-dependent diseases.