Abstract: Methods and compositions are provided for treating (e.g., therapeutically or prophylactically) gastrointestinal diseases, disorders, and conditions. In particular, one aspect provides compositions comprising Lactobacillus (e.g., Lactobacillus rhamnosus GG or other Lactobacillus species) p40 protein (e.g., isolated, recombinant, or overexpressed p40 protein) and methods of using same for treating a gastrointestinal disease, disorder, or condition.

Abstract: The present invention provides Orphanin FQ receptor nucleic acids and polypeptides and uses thereof. In particular, the present invention provides nucleic acid sequences of differentially expressed splice variants of the Orphanin FQ receptor. The present invention also provides methods of using the Orphanin FQ receptor nucleic acid sequences and ligands for the identification of pharmaceutical agents, the generation of animal models of Orphanin FQ receptor-mediated disease states, and for formulating biological activities. The present invention further provides improved methods of screening potential therapeutics useful in the treatment of a variety of disease states mediated by Orphanin FQ signaling, as well as therapeutics identified using the screening methods.

Abstract: The present invention provides Orphanin FQ receptor nucleic acid sequences. Specifically, the present invention provides nucleic acid sequences of differentially expressed splice variants of the Orphanin FQ receptor. The present invention also provides methods of using the Orphanin FQ receptor nucleic acid sequences for the identification of pharmaceutical agents and the generation of animal models of Orphanin FQ receptor-mediated disease states. The present invention thus provides improved method of screening potential therapeutics useful in the treatment of a variety of disease states mediated by Orphanin FQ signaling.

Abstract: The present invention provides Orphanin FQ receptor nucleic acids and polypeptides and uses thereof. In particular, the present invention provides nucleic acid sequences of differentially expressed splice variants of the Orphanin FQ receptor. The present invention also provides methods of using the Orphanin FQ receptor nucleic acid sequences and ligands for the identification of pharmaceutical agents, the generation of animal models of Orphanin FQ receptor-mediated disease states, and for formulating biological activities. The present invention further provides improved methods of screening potential therapeutics useful in the treatment of a variety of disease states mediated by Orphanin FQ signaling, as well as therapeutics identified using the screening methods.

Abstract: The present invention provides Orphanin FQ receptor nucleic acid sequences. Specifically, the present invention provides nucleic acid sequences of differentially expressed splice variants of the Orphanin FQ receptor. The present invention also provides methods of using the Orphanin FQ receptor nucleic acid sequences for the identification of pharmaceutical agents and the generation of animal models of Orphanin FQ receptor-mediated disease states. The present invention thus provides improved method of screening potential therapeutics useful in the treatment of a variety of disease states mediated by Orphanin FQ signaling.

Abstract: The present invention provides Orphanin FQ receptor nucleic acid sequences. Specifically, the present invention provides nucleic acid sequences of differentially expressed splice variants of the Orphanin FQ receptor. The present invention also provides methods of using the Orphanin FQ receptor nucleic acid sequences for the identification of pharmaceutical agents and the generation of animal models of Orphanin FQ receptor-mediated disease states. The present invention thus provides improved method of screening potential therapeutics useful in the treatment of a variety of disease states mediated by Orphanin FQ signaling.

Abstract: The present invention provides Orphanin FQ receptor nucleic acid sequences. Specifically, the present invention provides nucleic acid sequences of differentially expressed splice variants of the Orphanin FQ receptor. The present invention also provides methods of using the Orphanin FQ receptor nucleic acid sequences for the identification of pharmaceutical agents and the generation of animal models of Orphanin FQ receptor-mediated disease states. The present invention thus provides improved method of screening potential therapeutics useful in the treatment of a variety of disease states mediated by Orphanin FQ signaling.

Abstract: Methods and compositions are described for the treatment of intestinal disorders, and, more specifically, for improving motility in the colon in humans and animals. Compositions comprising neuropeptides are administered to humans and animals having symptoms of post-operative ileus.