Abstract: An electronic device with speakerphone and microphone is provided. The electronic device comprises a housing, a sound input unit, a sound output unit, an audio signal receiving terminal, an acoustic processing unit, a signal line and a sealing member. The housing has a microphone shell, a speaker shell and a soundproof structure. The soundproof structure is connected between the microphone shell and the speaker shell. The soundproof structure has a line output hole. The acoustic processing unit connects the sound input unit and the audio signal receiving terminal respectively to receive and mix two audio signals so as to generate an audio output signal. The audio output signal is transmitted to the sound output unit through a signal line. The sealing member is disposed around the line output hole and seals the line output hole.