Abstract: A seal ring structure is provided. The seal ring structure includes a seal ring on a semiconductor substrate. The seal ring includes a first interconnect element and a plurality of second interconnect elements. The first interconnect element is formed on a shallow trench isolation (STI) region and a first group of P-type doping regions over the semiconductor substrate. The second interconnect elements are formed below the first interconnect element and on a second group of P-type doping regions over the semiconductor substrate. The second interconnect elements are electrically separated from the first interconnect element, and the first and second groups of P-type doping regions are separated by the STI region.

Abstract: A seal ring structure is provided. The seal ring structure includes a seal ring on a semiconductor substrate. The seal ring includes a first interconnect element and a plurality of second interconnect elements. The first interconnect element is formed on a shallow trench isolation (STI) region and a first group of P-type doping regions over the semiconductor substrate. The second interconnect elements are formed below the first interconnect element and on a second group of P-type doping regions over the semiconductor substrate. The second interconnect elements are electrically separated from the first interconnect element, and the first and second groups of P-type doping regions are separated by the STI region.

Abstract: The present invention discloses a method and an apparatus of the drift calibration of sensors. The method includes shifting the sensing signal and differential technology to remove the drift signal by time during a long measuring. The apparatus includes two voltage sensors and readout circuits, a signal-shifting circuit and a differential circuit, and the apparatus is used for outputting the response signal without time drifting.

Abstract: Polyallylamine conjugates and applications thereof for biological signal amplification are provided by utilizing the essential amino group of polyallylamine to covalently bind with capture agents and signal molecules having the functional groups selected from a group consisting of —NHS, —CO, —S?O2 and —C?O—C?O. The resulting conjugates having more than one signaling entities can be further implemented for biological expression with enhancing effect on biological signal intensity, such that the sensitivity of detection for the variation between biological interactions is largely increased.

Abstract: An ion solution concentration-detecting device includes a working electrode, a reference electrode, and a link element. The working electrode and the reference electrode are inserted into the link element. The working electrode, inserted into the link element, is replaceable, for the better sensitivity to the different ion solution. The working electrode being a contact-detecting electrode can be replaced by another contact-detecting electrode with different sensing membrane. The reference electrode includes a polymeric membrane with ion material covering silver/silver chloride (Ag/AgCl) electrode to provide a fixed and stable electrical potential. The working electrode may be a contact-detecting electrode having a sensing membrane. The sensing membrane may be a metal oxide or a polymer with ion material for measuring different ion solution effectively.

Abstract: The present invention provides a substrate for protein microarrays, whereby compound A and GPTS are mixed for coating onto a solid support to form a layer, wherein said compound A is selected from a group consisting of nitrocellulose, poly(styrene-co-maleic anhydride) and polyvinylidene fluoride. Moreover, the present invention also provides a protein microarray by depositing proteins on said layer of said substrate.

Abstract: A data acquisition system for a solid-state urea biosensor uses an amplifier, a low-pass filter and a data acquisition card to acquire and relay data to a computer to be analyzed by a signal analysis program and displayed on a display panel. The biosensor includes a substrate, and three individual sensing areas separated by an insulating layer on the substrate. Each individual sensing area contains a conductive layer on the substrate, and a pH sensitive membrane is deposited thereon. An enzyme layer is deposited on one of the pH sensitive membranes to form a working electrode. The other two sensing areas are a quasi-reference electrode and a contrast electrode, respectively. The signals are transferred to an instrumentation amplifier. The amplified signals are then transferred to a low-pass filter. The filtered signals are analyzed by the program and then displayed on the display panel.

Abstract: A method for preparing a multi-level flash memory device comprises forming a dielectric stack including a charge-trapping layer on a semiconductor substrate, forming an insulation structure having a depression on the charge-trapping layer, removing a portion of the charge-trapping layer from the depression such that the charge-trapping layer is segmented to form a plurality of storage nodes, forming a gate oxide layer isolating the storage nodes and forming a damascene gate including a polysilicon layer filling the depression.

Abstract: A method of fabricating an electrode assembly of a sensor is described. The sensor has a field effect transistor. The electrode assembly is separated from the field effect transistor by only a conductive line. The sensor is functioned to detect different glucose concentrations. A solid layer of tin oxide is deposited on a substrate board. A ?-D-glucose oxidase and polyvinyl alcohol bearing styrylpyridinium groups are placed in 100 ?l of sulfuric acid, to form an enzyme mixture. The enzyme mixture is dropped on the solid layer of tin oxide. The enzyme mixture is dried. The enzyme mixture is exposed to a UV ray. The enzyme mixture is dried and stabilized. The enzyme mixture is immersed in a sulfuric buffer.

Abstract: A semiconductor device with an L-shape spacer and the method for manufacturing the same are provided. The semiconductor device comprises a substrate, a composite spacer, and a tunnel insulating layer. The substrate comprises a shallow trench isolation structure and a neighboring active area. The composite spacer is formed on the sidewall of the shallow trench isolation structure, and further comprises a first insulating layer and an L-shape second insulating layer spacer, wherein the first insulating layer is located between the L-shape second insulating layer spacer and the substrate. The tunnel insulating layer is located on the substrate of the active area and connects to the first insulating layer of the composite spacer on its corresponding side.

Abstract: A method for preparing a flash memory structure comprises the steps of forming a plurality of dielectric blocks having block sidewalls on a substrate, forming a plurality of first spacers on the block sidewalls of the dielectric blocks, removing a portion of the substrate not covered by the dielectric blocks and the first spacers to form a plurality of trenches in the substrate, performing a deposition process to form an isolation dielectric layer filling the trenches, removing the dielectric blocks to expose spacer sidewalls of the first spacers, forming a plurality of second spacers on the spacer sidewalls of the first spacers, and removing a portion of the substrate not covered by the first spacers, the second spacers and the isolation dielectric layer to form a plurality of second trenches in the substrate.

Abstract: A solid-state urea biosensor may comprise a substrate, an electrically conductive layer, a PH sensing film, an ammonium ion selecting film and a ferment film. The electrically conductive layer covers the substrate. The PH sensing film has a PH value measuring zone, partially covering the electrically conductive layer, for measuring the PH value of a solution to be tested. The ammonium ion selecting film has an ammonium ion measuring zone for measuring the ammonium ion concentration. The ammonium ion selecting film partially covers the PH sensing film and exposes the PH value measuring zone. The ferment film is used for measuring the urea concentration in the solution, wherein the ferment film partially covers the ammonium ion selecting film and exposes the ammonium ion measuring zone.

Abstract: A method for fabricating a non-volatile memory is provided. Parallel-arranged isolation structures are disposed in a substrate and protrude from the surface of the substrate to define active regions. Mask layers intersecting the isolation structures are deposited on the substrate. The surface of the mask layers is higher than that of the isolation structures. Doped regions are formed in the substrate. Insulating layers are deposited on the substrate between the mask layers. The insulating layers and the mask layers have different etch selectivities. The mask layers are removed to expose the substrate. A tunneling dielectric layer is formed on the substrate. A floating gate is deposited on the substrate surrounded by the isolation structures and the insulating layers. The surface of the floating gate is lower than that of the isolation structures. An inter-gate dielectric layer is deposited on the substrate. A control gate is disposed between the insulating layers.

Abstract: A novel NAND flash memory cell array and the method of fabricating the same are disclosed in this invention. The NAND flash memory cell array comprises a substrate with an active area; a plurality of cells arranged in a row on the active area; a first barrier layer covering the cells and the active area around each end of the row; a first oxide deposited to fill a gap between the cells; an oxide spacer formed along the sidewall of a cell located at each end of the row; and a poly spacer formed on the oxide spacer acting as a selection gate for driving the row of cells. The aspect ratio of the gap between the cells is about 1.8 to 3.2. Many advantages are provided with such NAND flash memory fabricating by the self-aligned process of the present invention.

Abstract: A method for fabricating an array pH sensor and a readout circuit device of such array pH sensor are implemented by utilizing an extended ion sensitive field effect transistor to construct the array pH sensor and related readout circuit. The structure of the array sensor having this extended ion sensitive field effect transistor comprises a tin dioxide/metal/silicon dioxide multi-layer structure sensor and a tin dioxide/indium tin oxide/glass multi-layer structure sensor and has excellent properties. Furthermore, the readout circuit and the sensor utilize two signal generators for controlling and reading signals. In particular, the sensor can be effective for increasing the accuracy of measurement and reducing the interference of noise.

Abstract: The invention provides a method of fabrication of a solid-state urea biosensor and its data acquisition system. The biosensor includes a substrate, and three individual sensing areas separated by an insulating layer on the substrate. Each individual sensing area contains a conductive layer on the substrate, and a pH sensitive membrane is deposited thereon. An enzyme layer is deposited on one of the pH sensitive membranes to form a working electrode. The other two sensing areas are a quasi-reference electrode and a contrast electrode, respectively. The sensing signals are transferred to an instrumentation amplifier by conductive wires. The sensing signals are then transferred to a low-pass filter to reduce the high frequency noise. A data acquisition card is employed to transfer the sensing signals to a computer. The sensing signals are analyzed by the program of the data acquisition system. The data are then displayed on the display panel.

Abstract: An ion solution concentration-detecting device includes a working electrode, a reference electrode and a replaceable link element. The reference electrode includes a polymeric membrane with ion material covering silver/silver chloride (Ag/AgCl) electrode to provide a fixed and stable electrical potential. The working electrode usually is a contact-detecting electrode having a sensing membrane. The sensing membrane may be a metal oxide or a polymer with ion material for measuring different ion solution effectively. For the better sensitivity to the different ion solution, the working electrode bond with the replaceable link element is replaceable. The working electrode being a contact-detecting electrode can be replaced by another contact-detecting electrode with different sensing membrane.

Abstract: A semiconductor device with an L-shape spacer and the method for manufacturing the same are provided. The semiconductor device comprises a substrate, a composite spacer, and a tunnel insulating layer. The substrate comprises a shallow trench isolation structure and a neighboring active area. The composite spacer is formed on the sidewall of the shallow trench isolation structure, and further comprises a first insulating layer and an L-shape second insulating layer spacer, wherein the first insulating layer is located between the L-shape second insulating layer spacer and the substrate. The tunnel insulating layer is located on the substrate of the active area and connects to the first insulating layer of the composite spacer on its corresponding side.

Abstract: The present invention discloses a method and an apparatus of the drift calibration of sensors. The method includes shifting the sensing signal and differential technology to remove the drift signal by time during a long measuring. The apparatus includes two voltage sensors and readout circuits, a signal-shifting circuit and a differential circuit, and the apparatus is used for outputting the response signal without time drifting.

Abstract: A method of fabricating an electrode assembly of a sensor is described. The sensor has a field effect transistor. The electrode assembly is separated from the field effect transistor by only a conductive line. The sensor is functioned to detect different glucose concentrations. A solid layer of tin oxide is deposited on a substrate board. A ?-D-glucose oxidase and polyvinylalchol bearing styrylpyridinium groups are placed in 100 ?l of sulfuric acid, to form an enzyme mixture. The enzyme mixture is dropped on the solid layer of tin oxide. The enzyme mixture is dried. The enzyme mixture is exposed to a UV ray. The enzyme mixture is dried and stabilized. The enzyme mixture is immersed in a sulfuric buffer.