Patents by Inventor Chung Y. HSU

Chung Y. HSU has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHOD FOR ENHANCING EXPRESSION OF INSULIN LIKE GROWTH FACTOR 1 RECEPTOR IN UMBILICAL CORD MESENCHYMAL STEM CELL AND METHOD FOR OBTAINING MULTIPOTENT UMBILICAL CORD MESENCHYMAL STEM CELL
    Publication number: 20230056048
    Abstract: A method for enhancing an expression of insulin like growth factor 1 receptor in an umbilical cord mesenchymal stem cell is provided. The method includes culturing the umbilical cord mesenchymal stem cell expressing insulin-like growth factor 1 receptor in a medium containing platelet-derived growth factor BB (PDGF-BB) to enhance the expression of insulin like growth factor 1 receptor in the umbilical cord mesenchymal stem cell.
    Type: Application
    Filed: November 7, 2022
    Publication date: February 23, 2023
    Applicant: China Medical University
    Inventors: Woei-Cherng Shyu, Chen-Huan Lin, Wei Lee, Chia-Hung Hsieh, Chung-Y. Hsu, Chang-Hai Tsai
  • Method for enhancing expression of insulin like growth factor 1 receptor in mesenchymal stem cell, method for obtaining mesenchymal stem cell, and method for treating brain tissue damage
    Patent number: 11529373
    Abstract: A method for enhancing an expression of insulin like growth factor 1 receptor in a mesenchymal stem cell is provided. The method includes culturing the mesenchymal stem cell expressing insulin-like growth factor 1 receptor in a medium containing platelet-derived growth factor BB (PDGF-BB) to enhance the expression of insulin like growth factor 1 receptor in the mesenchymal stem cell.
    Type: Grant
    Filed: March 31, 2020
    Date of Patent: December 20, 2022
    Assignee: China Medical University
    Inventors: Woei-Cherng Shyu, Chen-Huan Lin, Wei Lee, Chia-Hung Hsieh, Chung-Y. Hsu, Chang-Hai Tsai
  • Method for treating multiple sclerosis
    Patent number: 11110129
    Abstract: A method for treating a multiple sclerosis is provided. The method includes administering a composition containing a plurality of mesenchymal stem cells to a subject in need for a treatment of the multiple sclerosis, in which each of the mesenchymal stem cells expresses insulin-like growth factor 1 receptors.
    Type: Grant
    Filed: March 14, 2019
    Date of Patent: September 7, 2021
    Assignee: China Medical University
    Inventors: Woei-Cherng Shyu, Chen-Huan Lin, Wei Lee, Chia-Hung Hsieh, Chung-Y Hsu, Chang-Hai Tsai
  • Methods for obtaining pluripotent adult olfactory stem cells from an olfactory mucosa tissue
    Patent number: 10988733
    Abstract: A method for obtaining a plurality of pluripotent adult olfactory stem cells (APOSCs) includes isolating the APOSCs, culturing the isolated APOSCs in a sphere culture medium, and collecting the cultured APOSCs that express Bmi-1 (B-lymphoma moloney murine leukemia virus insertion region-1), Oct-4 (Octamer-binding transcription factor 4), Sox-2 (Sex-determining region Y (SRY)-box 2), Nanog, SSEA-4 (Stage-specific embryonic antigen-4), ki67, c-Myc, KLF-4 (Kruppel Like Factor 4), K14 (Cytokeratin 14) and ICAM-1 (Intercellular Adhesion Molecule 1).
    Type: Grant
    Filed: May 19, 2020
    Date of Patent: April 27, 2021
    Assignee: China Medical University
    Inventors: Woei-Cherng Shyu, Chung-Y. Hsu, Der-Yang Cho, Chen-Huan Lin, Wei Lee, San-Yuan Chen, Long-Bin Jeng, Chang-Hai Tsai
  • Method For Obtaining Pluripotent Adult Olfactory Stem Cell
    Publication number: 20200277569
    Abstract: A method for obtaining a plurality of pluripotent adult olfactory stem cells (APOSCs) includes isolating the APOSCs, culturing the isolated APOSCs in a sphere culture medium, and collecting the cultured APOSCs that express Bmi-1 (B-lymphoma moloney murine leukemia virus insertion region-1), Oct-4 (Octamer-binding transcription factor 4), Sox-2 (Sex-determining region Y (SRY)-box 2), Nanog, SSEA-4 (Stage-specific embryonic antigen-4), ki67, c-Myc, KLF-4 (Kruppel Like Factor 4), K14 (Cytokeratin 14) and ICAM-1 (Intercellular Adhesion Molecule 1).
    Type: Application
    Filed: May 19, 2020
    Publication date: September 3, 2020
    Applicant: China Medical University
    Inventors: Woei-Cherng Shyu, Chung-Y. Hsu, Der-Yang Cho, Chen-Huan Lin, Wei Lee, San-Yuan Chen, Long-Bin Jeng, Chang-Hai Tsai
  • Method For Enhancing Expression Of Insulin Like Growth Factor 1 Receptor In Mesenchymal Stem Cell, Method For Obtaining Mesenchymal Stem Cell, And Method For Treating Brain Tissue Damage
    Publication number: 20200246388
    Abstract: A method for enhancing an expression of insulin like growth factor 1 receptor in a mesenchymal stem cell is provided. The method includes culturing the mesenchymal stem cell expressing insulin-like growth factor 1 receptor in a medium containing platelet-derived growth factor BB (PDGF-BB) to enhance the expression of insulin like growth factor 1 receptor in the mesenchymal stem cell.
    Type: Application
    Filed: March 31, 2020
    Publication date: August 6, 2020
    Applicant: China Medical University
    Inventors: Woei-Cherng Shyu, Chen-Huan Lin, Wei Lee, Chia-Hung Hsieh, Chung-Y. Hsu, Chang-Hai Tsai
  • Methods for treating a brain tissue damage by cultured adult pluripotent olfactory stem cells
    Patent number: 10696945
    Abstract: A composition including adult pluripotent olfactory stem cells is provided. The adult pluripotent olfactory stem cells are obtained by culturing a cell mixture from an olfactory tissue of a mammal in media containing growth factors and then isolating cells which express B-lymphoma moloney murine leukemia virus insertion region-1 (Bmi-1).
    Type: Grant
    Filed: June 6, 2017
    Date of Patent: June 30, 2020
    Assignee: China Medical University
    Inventors: Woei-Cherng Shyu, Chung-Y. Hsu, Der-Yang Cho, Chen-Huan Lin, Wei Lee, San-Yuan Chen, Long-Bin Jeng, Chang-Hai Tsai
  • Method for enhancing insulin like growth factor 1 receptor expression of mesenchymal stem cell, method for isolating mesenchymal stem cell, and use of mesenchymal stem cell
    Patent number: 10660918
    Abstract: A method for enhancing an insulin like growth factor 1 receptor expression of a mesenchymal stem cell is provided. The method includes culturing a plurality of mesenchymal stem cells expressing insulin-like growth factor 1 receptors in media containing human cord blood serum to enhance the insulin like growth factor 1 receptor expression of the mesenchymal stem cells.
    Type: Grant
    Filed: December 26, 2017
    Date of Patent: May 26, 2020
    Assignee: China Medical University
    Inventors: Woei-Cherng Shyu, Chen-Huan Lin, Wei Lee, Chia-Hung Hsieh, Chung-Y. Hsu, Chang-Hai Tsai
  • Method for Treating Multiple Sclerosis
    Publication number: 20190201450
    Abstract: A method for treating a multiple sclerosis is provided. The method includes administering a composition containing a plurality of mesenchymal stem cells to a subject in need for a treatment of the multiple sclerosis, in which each of the mesenchymal stem cells expresses insulin-like growth factor 1 receptors.
    Type: Application
    Filed: March 14, 2019
    Publication date: July 4, 2019
    Inventors: Woei-Cherng Shyu, Chen-Huan Lin, Wei Lee, Chia-Hung Hsieh, Chung-Y Hsu, Chang-Hai Tsai
  • Bicyclic compound and pharmaceutical composition thereof for treating stroke and use thereof
    Patent number: 10035791
    Abstract: The present disclosure relates to a bicyclic compound, a pharmaceutical composition thereof, and its novel use. More particularly, the present disclosure relates to the bicyclic compound according to Formula I or Formula II, the pharmaceutical composition for treating a stroke, and the use of the bicyclic compound treating the stroke.
    Type: Grant
    Filed: October 6, 2016
    Date of Patent: July 31, 2018
    Assignee: China Medical University
    Inventors: Kuo-Hsiung Lee, Yu Zhao, Sheng-Chu Kuo, Chung-Y. Hsu, Woei-Cherng Shyu, Yu-Chian Chen, Chen-Huan Lin, Wei Lee, Chun-Wei Chiang, Chang-Hai Tsai
  • COMPOSITION INCLUDING ADULT PLURIPOTENT OLFACTORY STEM CELL, METHOD FOR ISOLATING PLURIPOTENT ADULT OLFACTORY STEM CELL, AND USE THEREOF
    Publication number: 20180187146
    Abstract: A composition including adult pluripotent olfactory stem cells is provided. The adult pluripotent olfactory stem cells are obtained by culturing a cell mixture from an olfactory tissue of a mammal in media containing growth factors and then isolating cells which express B-lymphoma moloney murine leukemia virus insertion region-1 (Bmi-1).
    Type: Application
    Filed: June 6, 2017
    Publication date: July 5, 2018
    Inventors: Woei-Cherng SHYU, Chung-Y. HSU, Der-Yang CHO, Chen-Huan LIN, Wei LEE, San-Yuan CHEN, Long-Bin JENG, Chang-Hai TSAI
  • METHOD FOR ENHANCING INSULIN LIKE GROWTH FACTOR 1 RECEPTOR EXPRESSION OF MESENCHYMAL STEM CELL, METHOD FOR ISOLATING MESENCHYMAL STEM CELL, AND USE OF MESENCHYMAL STEM CELL
    Publication number: 20180133259
    Abstract: A method for enhancing an insulin like growth factor 1 receptor expression of a mesenchymal stem cell is provided. The method includes culturing a plurality of mesenchymal stem cells expressing insulin-like growth factor 1 receptors in media containing human cord blood serum to enhance the insulin like growth factor 1 receptor expression of the mesenchymal stem cells.
    Type: Application
    Filed: December 26, 2017
    Publication date: May 17, 2018
    Inventors: Woei-Cherng SHYU, Chen-Huan LIN, Wei LEE, Chia-Hung HSIEH, Chung-Y. HSU, Chang-Hai TSAI
  • BICYCLIC COMPOUND AND PHARMACEUTICAL COMPOSITION THEREOF FOR TREATING STROKE AND USE THEREOF
    Publication number: 20170298049
    Abstract: The present disclosure relates to a bicyclic compound, a pharmaceutical composition thereof, and its novel use. More particularly, the present disclosure relates to the bicyclic compound according to Formula I or Formula II, the pharmaceutical composition for treating a stroke, and the use of the bicyclic compound treating the stroke.
    Type: Application
    Filed: October 6, 2016
    Publication date: October 19, 2017
    Inventors: Kuo-Hsiung LEE, Yu ZHAO, Sheng-Chu KUO, Chung-Y. HSU, Woei-Cherng SHYU, Yu-Chian CHEN, Chen-Huan LIN, Wei LEE, Chun-Wei CHIANG, Chang-Hai TSAI
  • 20()-sulfonylamidine derivatives of camptothecin and the use thereof as a potent antitumor agent
    Patent number: 9718835
    Abstract: The present invention is related to novel 20-sulfonylamidine derivatives of camptothecin (1), method of synthesizing the same, and use thereof as an antitumor agent, for examples an antitumor agent for treating nasopharyngeal, lung, breast or prostate cancer.
    Type: Grant
    Filed: September 26, 2014
    Date of Patent: August 1, 2017
    Assignees: CHINA MEDICAL UNIVERSITY HOSPITAL, THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL
    Inventors: Kuo-Hsiung Lee, Keduo Qian, Xiaoming Yang, Masuo Goto, Ying-Qian Liu, Yong-Long Zhao, Liu Yang, Mei-Juan Wang, Zhi-Jun Zhang, Tian-Shung Wu, Che-Ming Teng, Chih-Ya Wang, Shiow-Lin Pan, Sheng-Chu Kuo, Hsin-Yi Hung, Ling-Chu Chang, Yang-Chang Wu, Min-Tsang Hsieh, Chung Y. Hsu, Woei-Cherng Shyu, Chen-Huan Lin
  • MESENCHYMAL STEM CELL, METHOD FOR CLONOGENIC EXPANSION THEREOF, METHOD FOR ISOLATING THEREOF, AND USE THEREOF
    Publication number: 20170020924
    Abstract: A mesenchymal stem cell is provided. The mesenchymal stem cell that expresses an insulin-like growth factor 1 receptor have been cultured in media containing human cord blood serum and isolated, such that an insulin-like growth factor 1 receptor expression is enhanced in the isolated mesenchymal stem cells.
    Type: Application
    Filed: November 6, 2015
    Publication date: January 26, 2017
    Inventors: Woei-Cherng SHYU, Chen-Huan LIN, Wei LEE, Chia-Hung HSIEH, Chung-Y. HSU, Chang-Hai TSAI
  • NOVEL 20(S)-SULFONYLAMIDINE DERIVATIVES OF CAMPTOTHECIN AND THE USE THEREOF AS A POTENT ANTITUMOR AGENT
    Publication number: 20160229862
    Abstract: The present invention is related to novel 20-sulfonylamidine derivatives of camptothecin (1), method of synthesizing the same, and use thereof as an antitumor agent, for examples an antitumor agent for treating nasopharyngeal, lung, breast or prostate cancer.
    Type: Application
    Filed: September 26, 2014
    Publication date: August 11, 2016
    Inventors: Kuo-Hsiung LEE, Keduo QIAN, Xiaoming YANG, Masuo GOTO, Ying-Qian LIU, Yong-Long ZHAO, Liu YANG, Mei-Juan WANG, Zhi-Jun ZHANG, Tian-Shung WU, Che-Ming TENG, Chih-Ya WANG, Shiow-Lin PAN, Sheng-Chu KUO, Hsin-Yi HUNG, Ling-Chu CHANG, Yang-Chang WU, Min-Tsang HSIEH, Chung Y. HSU, Woei-Cherng SHYU, Chen-Huan LIN