Patents by Inventor Chung-Yuan Chiang
Chung-Yuan Chiang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11952449Abstract: The invention is related to a class of hydrophilic poly(meth)acrylamide-based copolymers each comprising dangling (i.e., pendant) reactive chains each terminated with a carboxyl group groups and at least 50% by mole of (meth)acrylamide repeating units relative to all repeating units of the hydrophilic poly(meth)acrylamide-based copolymer. The hydrophilic copolymers have a relatively high affinity to a base coating of a polyanionic polymer on a medical device or contact lens and are highly reactive towards azetidinium groups of an azetidinium-containing polymer upon heating. They can find particular use in producing water-soluble highly-branched hydrophilic polymeric material and in producing water gradient contact lenses.Type: GrantFiled: January 13, 2021Date of Patent: April 9, 2024Assignee: Alcon Inc.Inventors: Frank Chang, Feng Jing, Troy Vernon Holland, Chung-Yuan Chiang, John Dallas Pruitt
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Patent number: 11935871Abstract: A semiconductor package including a first semiconductor die, a second semiconductor die, a first insulating encapsulation, a dielectric layer structure, a conductor structure and a second insulating encapsulation is provided. The first semiconductor die includes a first semiconductor substrate and a through silicon via (TSV) extending from a first side to a second side of the semiconductor substrate. The second semiconductor die is disposed on the first side of the semiconductor substrate. The first insulating encapsulation on the second semiconductor die encapsulates the first semiconductor die. A terminal of the TSV is coplanar with a surface of the first insulating encapsulation. The dielectric layer structure covers the first semiconductor die and the first insulating encapsulation. The conductor structure extends through the dielectric layer structure and contacts with the through silicon via.Type: GrantFiled: August 30, 2021Date of Patent: March 19, 2024Assignee: Taiwan Semiconductor Manufacturing Company, Ltd.Inventors: Hao-Yi Tsai, Cheng-Chieh Hsieh, Tsung-Hsien Chiang, Hui-Chun Chiang, Tzu-Sung Huang, Ming-Hung Tseng, Kris Lipu Chuang, Chung-Ming Weng, Tsung-Yuan Yu, Tzuan-Horng Liu
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Patent number: 11933941Abstract: The invention is related to contact lenses that not only comprise the much desired water gradient structural configurations, but also have a minimized uptakes of polycationic antimicrobials and a long-lasting surface hydrophilicity and wettability even after going through a 30-days lens care regime. Because of the water gradient structural configuration and a relatively-thick, extremely-soft and water-rich hydrogel surface layer, a contact lens of the invention can provide superior wearing comfort. Further, a contact lens of the invention is compatible with multipurpose lens care solutions present in the market and can endure the harsh lens care handling conditions (e.g., digital rubbings, accidental inversion of contact lenses, etc.) encountered in a daily lens care regime. As such, they are suitable to be used as weekly- or monthly-disposable water gradient contact lenses.Type: GrantFiled: January 11, 2022Date of Patent: March 19, 2024Assignee: Alcon Inc.Inventors: Yongxing Qiu, John Dallas Pruitt, Newton T. Samuel, Chung-Yuan Chiang, Robert Carey Tucker, Yuan Chang, Ethan Leveillee
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Publication number: 20220372391Abstract: The present invention generally relates to a method for applying a coating of hydrophilic polymers onto polyvinylalcohol-based hydrogel contact lenses to improve lubricity. In particular, the present invention is directed to a method for forming a coating on a contact lens, preferably a polyvinylalcohol-based hydrogel contact lens, directly in the primary package and maintaining the coated contact lens within said primary package until insertion of the coated contact lens in the eye of the contact lens user. The resultant polyvinylalcohol-based hydrogel contact lens has a coating with improved lubricity and good durability and also can be used directly from the lens package by a patient without washing and/or rinsing.Type: ApplicationFiled: April 20, 2022Publication date: November 24, 2022Inventors: Chung-Yuan Chiang, Yongxing Qiu
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Patent number: 11459479Abstract: The invention is generally related to a method for producing coated silicone hydrogel contact lenses each of which has a hydrogel coating thereon and a relative high resistance to uptakes of polycationic antimicrobials as characterized by having a polyquaternium-1-uptake of less than 0.40 micrograms/lens. The hydrogel coating is formed by covalently attached a hydrophilic polymeric material onto a base coating of a polyanionic polymer on a SiHy contact lens. In this method, lower polyquaternium-1-uptake is achieved by using a rinse solution with a higher pH and/or a higher ionic strength (higher salt concentration) for rinsing a treated silicone hydrogel contact lens with a base coating of polyanionic polymer.Type: GrantFiled: May 30, 2019Date of Patent: October 4, 2022Assignee: Alcon Inc.Inventors: Yongxing Qiu, Chung-Yuan Chiang, Newton T. Samuel, Richard Govan, Ciara Dauenhauer
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Publication number: 20220299796Abstract: The invention is related to a method for producing soft contact lenses comprises a silicone hydrogel lens body and a composite coating thereon. The composite coating comprises: a plasma base coating which is chemically-attached directly onto the surface of the silicone hydrogel contact lens and functions as a fail-proof measure for ensuring the hydrophobic silicone hydrogel lens material to be shielded from any exposure to ocular environments even after at least 30 days of daily uses including daily waring and daily cleaning/disinfecting; and a relatively-durable lubricious hydrogel top coating for ensuring wearing comfort.Type: ApplicationFiled: June 7, 2022Publication date: September 22, 2022Inventors: Yongxing Qiu, John Dallas Pruitt, Kelly Kayi Tallau, Angela Driver-Scott, Chung-Yuan Chiang
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Patent number: 11385478Abstract: The invention is related to a method for producing soft contact lenses comprises a silicone hydrogel lens body and a composite coating thereon. The composite coating comprises: a plasma base coating which is chemically-attached directly onto the surface of the silicone hydrogel contact lens and functions as a fail-proof measure for ensuring the hydrophobic silicone hydrogel lens material to be shielded from any exposure to ocular environments even after at least 30 days of daily uses including daily waring and daily cleaning/disinfecting; and a relatively-durable lubricious hydrogel top coating for ensuring wearing comfort.Type: GrantFiled: September 14, 2017Date of Patent: July 12, 2022Assignee: Alcon Inc.Inventors: Yongxing Qiu, John Dallas Pruitt, Kelly Kayi Tallau, Angela Driver-Scott, Chung-Yuan Chiang
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Publication number: 20220137263Abstract: The invention is related to contact lenses that not only comprise the much desired water gradient structural configurations, but also have a minimized uptakes of polycationic antimicrobials and a long-lasting surface hydrophilicity and wettability even after going through a 30-days lens care regime. Because of the water gradient structural configuration and a relatively-thick, extremely-soft and water-rich hydrogel surface layer, a contact lens of the invention can provide superior wearing comfort. Further, a contact lens of the invention is compatible with multipurpose lens care solutions present in the market and can endure the harsh lens care handling conditions (e.g., digital rubbings, accidental inversion of contact lenses, etc.) encountered in a daily lens care regime. As such, they are suitable to be used as weekly- or monthly-disposable water gradient contact lenses.Type: ApplicationFiled: January 11, 2022Publication date: May 5, 2022Inventors: Yongxing Qiu, John Dallas Pruitt, Newton T. Samuel, Chung-Yuan Chiang, Robert Carey Tucker, Yuan Chang, Ethan Leveillee
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Patent number: 11256003Abstract: The invention is related to contact lenses that not only comprise the much desired water gradient structural configurations, but also have a minimized uptakes of polycationic antimicrobials and a long-lasting surface hydrophilicity and wettability even after going through a 30-days lens care regime. Because of the water gradient structural configuration and a relatively-thick, extremely-soft and water-rich hydrogel surface layer, a contact lens of the invention can provide superior wearing comfort. Further, a contact lens of the invention is compatible with multipurpose lens care solutions present in the market and can endure the harsh lens care handling conditions (e.g., digital rubbings, accidental inversion of contact lenses, etc.) encountered in a daily lens care regime. As such, they are suitable to be used as weekly- or monthly-disposable water gradient contact lenses.Type: GrantFiled: November 29, 2018Date of Patent: February 22, 2022Assignee: Alcon Inc.Inventors: Yongxing Qiu, John Dallas Pruitt, Newton T. Samuel, Chung-Yuan Chiang, Robert Carey Tucker, Yuan Chang, Ethan Leveillee
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Publication number: 20220032564Abstract: The invention is related to a coated contact lens, especially a coated silicone hydrogel contact lens, which comprises an anterior surface, an opposite posterior surface, and a layered structural configuration from the anterior surface to the posterior surface. The layered structural configuration comprises an outer anterior surface hydrogel layer, an inner layer, and an outer posterior surface hydrogel layer. The inner layer is a lens bulk material. The coated contact lens has a superior lens surface softness and a good lens surface hydrophilicity while optionally having a desirably-lower polyquaternium-1 uptake.Type: ApplicationFiled: July 27, 2021Publication date: February 3, 2022Inventors: Yongxing Qiu, John Dallas Pruitt, Ciara Dauenhauer, Chung-Yuan Chiang, Paul William Oyler, Robert Carey Tucker
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Patent number: 11029447Abstract: The invention is related to a process for producing contact lenses that not only comprise a water gradient structural configurations, but also have a minimized uptakes of polyquaternium-1 and a long-lasting surface hydrophilicity and wettability even after being undergone a simulated 30-days lens care regime.Type: GrantFiled: November 29, 2018Date of Patent: June 8, 2021Assignee: Alcon Inc.Inventors: Yongxing Qiu, John Dallas Pruitt, Newton T. Samuel, Chung-Yuan Chiang, Angela Driver-Scott, Ciara Dauenhauer, Rita Anand
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Publication number: 20210130644Abstract: The invention is related to a class of hydrophilic poly(meth)acrylamide-based copolymers each comprising dangling (i.e., pendant) reactive chains each terminated with a carboxyl group groups and at least 50% by mole of (meth)acrylamide repeating units relative to all repeating units of the hydrophilic poly(meth)acrylamide-based copolymer. The hydrophilic copolymers have a relatively high affinity to a base coating of a polyanionic polymer on a medical device or contact lens and are highly reactive towards azetidinium groups of an azetidinium-containing polymer upon heating. They can find particular use in producing water-soluble highly-branched hydrophilic polymeric material and in producing water gradient contact lenses.Type: ApplicationFiled: January 13, 2021Publication date: May 6, 2021Inventors: Frank Chang, Feng Jing, Troy Vernon Holland, Chung-Yuan Chiang, John Dallas Pruitt
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Patent number: 10920099Abstract: The invention is related to a class of hydrophilic poly(meth)acrylamide-based copolymers each comprising dangling (i.e., pendant) reactive chains each terminated with a carboxyl group groups and at least 50% by mole of (meth)acrylamide repeating units relative to all repeating units of the hydrophilic poly(meth)acrylamide-based copolymer. The hydrophilic copolymers have a relatively high affinity to a base coating of a polyanionic polymer on a medical device or contact lens and are highly reactive towards azetidinium groups of an azetidinium-containing polymer upon heating. They can find particular use in producing water-soluble highly-branched hydrophilic polymeric material and in producing water gradient contact lenses.Type: GrantFiled: July 17, 2018Date of Patent: February 16, 2021Assignee: Alcon Inc.Inventors: Frank Chang, Feng Jing, Troy Vernon Holland, Chung-Yuan Chiang, John Dallas Pruitt
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Patent number: 10830923Abstract: The invention is related to a process for producing contact lenses that not only comprise a water gradient structural configurations, but also have a minimized uptakes of polyquaternium-1 and a long-lasting surface hydrophilicity and wettability even after being undergone a simulated 30-days lens care regime.Type: GrantFiled: November 29, 2018Date of Patent: November 10, 2020Assignee: Alcon Inc.Inventors: Yongxing Qiu, Kasey Jon Minick, John Dallas Pruitt, Newton T. Samuel, Chung-Yuan Chiang, Kelly Kayi Tallau, Matthew McCollum, Richard Govan
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Patent number: 10676608Abstract: The invention is related to a class of hydrophilic poly(meth)acrylamide-based copolymer comprising dangling (i.e., pendant) phosphorylcholine groups and dangling (i.e., pendant) reactive groups or chains each of which comprises one carboxyl group, one thiol group, or one primary or secondary amino group. The hydrophilic copolymers have a relatively high affinity to a base coating of a polyanionic polymer on a medical device or contact lens and are reactive towards azetidinium groups of an azetidinium-containing polymer upon heating. They can find particular use in producing water-soluble highly-branched hydrophilic polymeric material and in producing water gradient contact lenses.Type: GrantFiled: July 17, 2018Date of Patent: June 9, 2020Assignee: Alcon Inc.Inventors: Frank Chang, Feng Jing, Troy Vernon Holland, Chung-Yuan Chiang, John Dallas Pruitt
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Publication number: 20200172756Abstract: The invention is generally related to a method for producing coated silicone hydrogel contact lenses each of which has a hydrogel coating thereon and a relative high resistance to uptakes of polycationic antimicrobials as characterized by having a polyquaternium-1-uptake of less than 0.40 micrograms/lens. The hydrogel coating is formed by covalently attached a hydrophilic polymeric material onto a base coating of a polyanionic polymer on a SiHy contact lens. In this method, lower polyquaternium-1-uptake is achieved by using a rinse solution with a higher pH and/or a higher ionic strength (higher salt concentration) for rinsing a treated silicone hydrogel contact lens with a base coating of polyanionic polymer.Type: ApplicationFiled: May 30, 2019Publication date: June 4, 2020Inventors: Yongxing Qiu, Chung-Yuan Chiang, Newton T. Samuel, Richard Govan, Ciara Dauenhauer
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Patent number: 10611923Abstract: The invention is related to azetidinium-containing copolymers and vinylic monomers and their uses in formation of non-silicone hydrogel coatings on silicone hydrogel contact lenses.Type: GrantFiled: August 8, 2018Date of Patent: April 7, 2020Assignee: Alcon Inc.Inventors: Troy Vernon Holland, Frank Chang, Yongxing Qiu, John Dallas Pruitt, Chung-Yuan Chiang, Venkat Shankar, Robert Scott, Yash Kapoor
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Patent number: 10526470Abstract: The invention is related to a cost-effective method for producing water-soluble thermally-crosslinkable hydrophilic polymeric materials. Resultant materials can find particular use in preparing a packaging solution used for packaging and autoclaving medical devices, especially contact lenses. Those packaging solutions are especially suitable for forming a relatively-thick and soft hydrogel coatings on contact lenses or medical devices according to an in-package-crosslinking (IPC) processes. The resultant non-silicone hydrogel coatings can have a superior lubricity (a friction rating of 0) with minimized or no surface cracking.Type: GrantFiled: September 14, 2017Date of Patent: January 7, 2020Assignee: Novartis AGInventors: Chung-Yuan Chiang, Yongxing Qiu, Kelly Kayi Tallau, Angela Driver-Scott
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Patent number: 10449740Abstract: The present invention generally relates to a method for producing silicone hydrogel contact lenses having a stable lubricious coating thereon without involving use of organic solvent in post-curing processes.Type: GrantFiled: December 13, 2016Date of Patent: October 22, 2019Assignee: Novartis AGInventors: Xinming Qian, Jared Nelson, Robert Carey Tucker, Steve Yun Zhang, Daqing Wu, Leroy Wainaina Muya, Dharmesh Patel, Zach Munoz, Yongxing Qiu, Chung-Yuan Chiang, Ritu Shrestha, Kelly Kayi Tallau
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Publication number: 20190176416Abstract: The invention is related to a process for producing contact lenses that not only comprise a water gradient structural configurations, but also have a minimized uptakes of polyquaternium-1 and a long-lasting surface hydrophilicity and wettability even after being undergone a simulated 30-days lens care regime.Type: ApplicationFiled: November 29, 2018Publication date: June 13, 2019Inventors: Yongxing Qiu, John Dallas Pruitt, Newton T. Samuel, Chung-Yuan Chiang, Angela Driver-Scott, Ciara Dauenhauer, Rita Anand