Patents by Inventor Chungen Pan

Chungen Pan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • RECOMBINANT ONCOLYTIC VIRUSES FOR TREATMENT OF METASTATIC CANCERS
    Publication number: 20200123204
    Abstract: Disclosed are recombinant oncolytic viruses that express one or more reovirus fusion-associated small transmembrane FAST) proteins and uses thereof. The oncolytic activity of the recombinant oncolytic viruses expressing FAST proteins can be used to treat primary and metastatic cancers, especially from breast and colon cancers.
    Type: Application
    Filed: June 22, 2018
    Publication date: April 23, 2020
    Inventors: Roy Duncan, Chungen Pan
  • Stabilized trimeric HIV-1 GP41 fusion inhibitor polypeptides comprising the N-terminal heptad repeat (NHR) and foldon (FD) trimerization motif
    Patent number: 9724383
    Abstract: Disclosed herein are trimeric polypeptide pharmaceutical compositions comprising three monomers, each monomer comprising a polypeptide having the amino acid sequence of the N-terminal heptad repeat (NHR or HR1) or C-terminal heptad repeat (CHR or HR2) of the transmembrane glycoprotein of human immunodeficiency virus (HIV) and a trimerization motif.
    Type: Grant
    Filed: July 10, 2015
    Date of Patent: August 8, 2017
    Assignee: New York Blood Center, Inc.
    Inventors: Shibo Jiang, Zhi Qi, Xi Chen, Chungen Pan
  • Trimeric HIV Fusion Inhibitors for Treating or Preventing HIV Infection
    Publication number: 20150306174
    Abstract: Disclosed herein are trimeric polypeptide pharmaceutical compositions comprising three monomers, each monomer comprising a polypeptide having the amino acid sequence of the N-terminal heptad repeat (NHR or HR1) or C-terminal heptad repeat (CHR or HR2) of the transmembrane glycoprotein of human immunodeficiency virus (HIV) and a trimerization motif.
    Type: Application
    Filed: July 10, 2015
    Publication date: October 29, 2015
    Inventors: Shibo Jiang, Zhi Qi, Xi Chen, Chungen Pan
  • Stabilized trimeric HIV-1 gp41 fusion polypeptides comprising the N-terminal heptad repeat (NHR) and foldon (FD) trimerization motif
    Patent number: 9115186
    Abstract: Disclosed herein are trimeric polypeptide pharmaceutical compositions comprising three monomers, each monomer comprising a polypeptide having the amino acid sequence of the N-terminal heptad repeat (NHR or HR1) or C-terminal heptad repeat (CHR or HR2) of the transmembrane glycoprotein of human immunodeficiency virus (HIV) and a trimerization motif.
    Type: Grant
    Filed: February 8, 2010
    Date of Patent: August 25, 2015
    Assignee: New York Blood Center
    Inventors: Shibo Jiang, Zhi Qi, Xi Chen, Chungen Pan
  • Immunoenhancer-linked oligomeric HIV envelope peptides
    Patent number: 8936789
    Abstract: Provided herein are immunogenic compositions comprising fusion proteins, the fusion proteins comprising lentivirus gp41 or a fragment thereof, a trimerization or oligomerization motif and an immunoenhancer that elicit potent and broad HIV neutralizing antibody responses in the immunized hosts. Also disclosed are methods of making and using the immunogenic compositions.
    Type: Grant
    Filed: October 16, 2009
    Date of Patent: January 20, 2015
    Assignee: New York Bood Center, Inc.
    Inventors: Shibo Jiang, Zhi Qi, Chungen Pan
  • Bifunctional molecules for inhibiting HIV entry
    Patent number: 8828931
    Abstract: Disclosed herein are bifunctional molecules which inhibit HIV entry into the target cell. Also disclosed are novel anti-HIV therapeutics for treatment of patients infected by HIV, including non-B and multi-drug resistant strains.
    Type: Grant
    Filed: May 28, 2009
    Date of Patent: September 9, 2014
    Assignee: New York Blood Center, Inc.
    Inventors: Shibo Jiang, Chungen Pan
  • Bifunctional molecules for inactivating HIV and blocking HIV entry
    Patent number: 8828932
    Abstract: Disclosed herein are bifunctional molecules which inactivate human immunodeficiency virus (HIV) even before the virus attacks the target cell and inhibits HIV entry into the target cell. Also disclosed are novel anti-HIV therapeutics for treatment of patients infected by HIV. Further disclosed are methods for prophylaxis against HIV and treatment of HIV infection.
    Type: Grant
    Filed: May 3, 2011
    Date of Patent: September 9, 2014
    Assignee: New York Blood Center, Inc.
    Inventors: Shibo Jiang, Chungen Pan, Lu Lu
  • BIFUNCTIONAL MOLECULES FOR INACTIVATING HIV AND BLOCKING HIV ENTRY
    Publication number: 20110269676
    Abstract: Disclosed herein are bifunctional molecules which inactivate human immunodeficiency virus (HIV) even before the virus attacks the target cell and inhibits HIV entry into the target cell. Also disclosed are novel anti-HIV therapeutics for treatment of patients infected by HIV. Further disclosed are methods for prophylaxis against HIV and treatment of HIV infection.
    Type: Application
    Filed: May 3, 2011
    Publication date: November 3, 2011
    Applicant: NEW YORK BLOOD CENTER
    Inventors: Shibo Jiang, Chungen Pan, Lu Lu
  • Highly potent synergistic combinations of human immunodeficiency virus (HIV) fusion inhibitors
    Patent number: 7919101
    Abstract: Provided herein are pharmaceutical compositions for the prophylactic and therapeutic treatment of HIV comprising combinations of HIV fusion/entry inhibitors that exhibit synergistic effect, including T-20 (enfuvirtide), T-1249, T-1144, C34, and sifuvirtide. Also disclosed are methods of treating HIV infection by administering such compositions.
    Type: Grant
    Filed: August 12, 2009
    Date of Patent: April 5, 2011
    Assignee: New York Blood Center
    Inventors: Shibo Jiang, Chungen Pan
  • TRIMERIC HIV FUSION INHIBITORS FOR TREATING OR PREVENTING HIV INFECTION
    Publication number: 20100204120
    Abstract: Disclosed herein are trimeric polypeptide pharmaceutical compositions comprising three monomers, each monomer comprising a polypeptide having the amino acid sequence of the N-terminal heptad repeat (NHR or HR1) or C-terminal heptad repeat (CHR or HR2) of the transmembrane glycoprotein of human immunodeficiency virus (HIV) and a trimerization motif.
    Type: Application
    Filed: February 8, 2010
    Publication date: August 12, 2010
    Inventors: Shibo Jiang, Zhi Qi, Xi Chen, Chungen Pan
  • IMMUNOENHACER-LINKED OLIGOMERIC HIV VACCINES
    Publication number: 20100098724
    Abstract: Provided herein are immunogenic compositions comprising fusion proteins, the fusion proteins comprising lentivirus gp41 or a fragment thereof, a trimerization or oligomerization motif and an immunoenhancer that elicit potent and broad HIV neutralizing antibody responses in the immunized hosts. Also disclosed are methods of making and using the immunogenic compositions.
    Type: Application
    Filed: October 16, 2009
    Publication date: April 22, 2010
    Inventors: Shibo Jiang, Zhi Qi, Chungen Pan
  • Combination Therapy of HIV Using Fusion/Entry Inhibitors Targeting GP41
    Publication number: 20100040631
    Abstract: Provided herein are pharmaceutical compositions for the prophylactic and therapeutic treatment of HIV comprising combinations of HIV fusion/entry inhibitors with different target sites in HIV gp41 or different mechanisms of action. Also disclosed are methods of treating HIV infection by administering such compositions.
    Type: Application
    Filed: August 12, 2009
    Publication date: February 18, 2010
    Inventors: Shibo Jiang, Chungen Pan
  • Bifunctional Molecules for Inhibiting HIV Entry
    Publication number: 20090298774
    Abstract: Disclosed herein are bifunctional molecules which inhibit HIV entry into the target cell. Also disclosed are novel anti-HIV therapeutics for treatment of patients infected by HIV, including non-B and multi-drug resistant strains.
    Type: Application
    Filed: May 28, 2009
    Publication date: December 3, 2009
    Inventors: Shibo Jiang, Chungen Pan