Patents by Inventor Chungen QIAN

Chungen QIAN has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20200309770
    Abstract: Provided are a chemiluminescence immunoassay kit for adiponectin, and a preparation method and a use thereof. The chemiluminescence immunoassay kit for adiponectin comprises: a solid carrier coated with an adiponectin monoclonal antibody; and an adiponectin monoclonal antibody marked with a chemiluminescence marker.
    Type: Application
    Filed: July 6, 2016
    Publication date: October 1, 2020
    Inventors: Fuzhen XIA, Chungen QIAN, Gang WANG, Liang ZHU, Yuxi HE
  • Patent number: 10745425
    Abstract: Disclosed a chemiluminescence enhancer and a chemiluminescence immunodetection kit. The chemiluminescence enhancer is specifically a betaine and can be used for enhancing the luminance of a luminescent acridine substance. The chemiluminescence immunodetection kit comprising the chemiluminescence enhancer and a luminescent acridine substance features greatly enhanced luminescence signals and high detection sensibility, and can be widely applied to fields such as clinical diagnoses, scientific research, and sanitation analysis.
    Type: Grant
    Filed: July 1, 2016
    Date of Patent: August 18, 2020
    Assignee: SHENZHEN YHLO BIOTECH CO., LTD.
    Inventors: Kunhui Hu, Gang Wang, Fuzhen Xia, Chungen Qian, Liang Zhu, Dingbiao Zou
  • Publication number: 20190323969
    Abstract: The present invention discloses a zinc transporter 8 antibody chemiluminescence immunoassay kit, including a magnetic microparticle working solution coated with purified zinc transporter 8, a purified zinc transporter 8 working solution labeled with acridinium ester, a zinc transporter 8 antibody calibrator, a chemiluminescent pre-excitation solution and a chemiluminescent excitation solution. In addition, the present invention also discloses a method for preparing the zinc transporter 8 antibody chemiluminescence immunoassay kit.
    Type: Application
    Filed: April 13, 2017
    Publication date: October 24, 2019
    Applicant: SHENZHEN YHLO BIOTECH CO., LTD.
    Inventors: Lin HE, Qiaohong CHEN, Yonghong YANG, Fuzhen XIA, Chungen QIAN, Xing LIU
  • Publication number: 20190309030
    Abstract: Disclosed are an acridine marker conjugate and a preparation method therefor and a chemiluminescent kit. The acridine marker conjugate comprises an acridine substitute, a carrier protein and a protein to be marked sequentially connected. The carrier protein is a protein containing carboxyl and amino, a modified protein, a polypeptide or a modified polypeptide; and the protein to be marked is a protein containing amino, a modified protein, a polypeptide or a modified polypeptide.
    Type: Application
    Filed: July 5, 2016
    Publication date: October 10, 2019
    Inventors: Fuzhen XIA, Taoxu LIU, Liang ZHU, Chengyong XIAO, Chungen QIAN
  • Publication number: 20190153003
    Abstract: Disclosed a chemiluminescence enhancer and a chemiluminescence immunodetection kit. The chemiluminescence enhancer is specifically a betaine and can be used for enhancing the luminance of a luminescent acridine substance. The chemiluminescence immunodetection kit comprising the chemiluminescence enhancer and a luminescent acridine substance features greatly enhanced luminescence signals and high detection sensibility, and can be widely applied to fields such as clinical diagnoses, scientific research, and sanitation analysis.
    Type: Application
    Filed: July 1, 2016
    Publication date: May 23, 2019
    Inventors: Kunhui HU, Gang WANG, Fuzhen XIA, Chungen QIAN, Liang ZHU, Dingbiao ZOU
  • Patent number: 9139766
    Abstract: An enhancing reagent for enhancing chemiluminescence of 1,2-dioxetane compounds and a method for using the enhancing reagent to enhance the chemiluminescence are provided, in which the enhancing reagent contains an alkyl bis-quaternary ammonium salt of Formula I. A chemiluminescent composition with a 1,2-dioxetane compound as a substrate and a kit thereof are further provided, which contain a 1,2-dioxetane compound and an alkyl bis-quaternary ammonium salt of Formula I.
    Type: Grant
    Filed: October 10, 2013
    Date of Patent: September 22, 2015
    Assignee: SHENZHEN MINDRAY BIO-MEDICAL ELECTRONICS CO., LTD.
    Inventors: Chungen Qian, Yuping Zhang
  • Patent number: 8940512
    Abstract: Methods for synthesizing an ALP conjugate are provided. The methods may include activating a carboxyl group of the ALP with a carbodiimide, to generate an active ester; and adding the substance to be conjugated such that a synthetic reaction occurs between the active ester and the substance to be conjugated, to generate an ALP conjugate.
    Type: Grant
    Filed: June 2, 2011
    Date of Patent: January 27, 2015
    Assignee: Shenzhen Mindray Bio-Medical Electronics Co., Ltd.
    Inventors: Chungen Qian, Ke Li, Yuping Zhang
  • Patent number: 8883514
    Abstract: A enhancing reagent for enhancing chemiluminescence of 1,2-dioxetane compounds and a method for using the enhancing reagent to enhance chemiluminescence are provided, in which the enhancing reagent contains a multi-alkyl quaternary ammonium salt of Formula I. A chemiluminescent composition with a 1,2-dioxetane compound as a substrate and a kit thereof are further provided, which contain a 1,2-dioxetane compound and a multi-alkyl quaternary ammonium salt of Formula I.
    Type: Grant
    Filed: June 29, 2011
    Date of Patent: November 11, 2014
    Assignee: Shenzhen Mindray Bio-Medical Electronics Co., Ltd.
    Inventors: Chungen Qian, Yuping Zhang
  • Patent number: 8753858
    Abstract: The present disclosure relates to stabilizers for alkaline phosphatase or conjugates thereof, a process for preparing a stabilizer, and a method for stabilizing alkaline phosphatase or conjugates thereof with a stabilizer. The present disclosure also relates to a reagent of alkaline phosphatase or conjugates thereof as well as to a process for preparing the same. In another aspect, the present disclosure relates to a kit comprising the stabilizers disclosed herein and alkaline phosphatase or conjugates thereof. The stabilizer disclosed herein can stabilize alkaline phosphatase or conjugates thereof for a prolonged period of time, extending their shelf-life.
    Type: Grant
    Filed: December 29, 2010
    Date of Patent: June 17, 2014
    Assignee: Shenzhen Mindray Bio-Medical Electronics Co., Ltd.
    Inventors: Chungen Qian, Yuping Zhang
  • Publication number: 20140103272
    Abstract: An enhancing reagent for enhancing chemiluminescence of 1,2-dioxetane compounds and a method for using the enhancing reagent to enhance the chemiluminescence are provided, in which the enhancing reagent contains an alkyl bis-quaternary ammonium salt of Formula I. A chemiluminescent composition with a 1,2-dioxetane compound as a substrate and a kit thereof are further provided, which contain a 1,2-dioxetane compound and an alkyl bis-quaternary ammonium salt of Formula I.
    Type: Application
    Filed: October 10, 2013
    Publication date: April 17, 2014
    Inventors: Chungen Qian, Yuping Zhang
  • Patent number: 8563321
    Abstract: A enhancing reagent for enhancing chemiluminescence of 1,2-dioxetane compounds and a method for using the enhancing reagent to enhance the chemiluminescence are provided, in which the enhancing reagent contains an alkyl bis-quaternary ammonium salt of Formula I. A chemiluminescent composition with a 1,2-dioxetane compound as a substrate and a kit thereof are further provided, which contain a 1,2-dioxetane compound and an alkyl bis-quaternary ammonium salt of Formula I.
    Type: Grant
    Filed: July 6, 2011
    Date of Patent: October 22, 2013
    Assignee: Shenzhen Mindray Bio-Medical Electronics Co., Ltd.
    Inventors: Chungen Qian, Yuping Zhang
  • Patent number: 8557147
    Abstract: The present disclosure provides a chemiluminescent composition where the chemiluminescent substrate is 1,2-dioxetane, which contains 1,2-dioxetane and an alkyl dimethyl benzyl quaternary ammonium salt having the structure of general formula I. The present disclosure also provides an enhancing reagent and methods for enhancing chemiluminescence of 1,2-dioxetane, where the enhancing reagent contains an alkyl dimethyl benzyl quaternary ammonium salt having the structure of general formula I.
    Type: Grant
    Filed: June 29, 2011
    Date of Patent: October 15, 2013
    Assignee: Shenzhen Mindray Bio-Medical Electronics Co., Ltd.
    Inventors: Chungen Qian, Yuping Zhang
  • Patent number: 8476050
    Abstract: Methods for preparing conjugates including enzyme conjugates and especially alkaline phosphatase (ALP) conjugates, and a kit are provided. The methods include: blocking an amino group on a molecule surface of a first substance to be conjugated containing an amino group and a carboxyl group (for example, an enzyme) with a carboxyl compound; adding a carbodiimide to activate the first substance to be conjugated with the amino group blocked; inactivating or removing the carbodiimide; and adding a second substance containing an amino group (for example, a substance to be labeled). Conjugates (for example, enzyme conjugates) are obtained.
    Type: Grant
    Filed: June 2, 2011
    Date of Patent: July 2, 2013
    Assignee: Shenzhen Mindray Bio-Medical Electronics Co., Ltd.
    Inventors: Chungen Qian, Ke Li, Yuping Zhang
  • Publication number: 20120015446
    Abstract: A enhancing reagent for enhancing chemiluminescence of 1,2-dioxetane compounds and a method for using the enhancing reagent to enhance the chemiluminescence are provided, in which the enhancing reagent contains an alkyl bis-quaternary ammonium salt of Formula I. A chemiluminescent composition with a 1,2-dioxetane compound as a substrate and a kit thereof are further provided, which contain a 1,2-dioxetane compound and an alkyl bis-quaternary ammonium salt of Formula I.
    Type: Application
    Filed: July 6, 2011
    Publication date: January 19, 2012
    Applicant: SHENZHEN MINDRAY BIO-MEDICAL ELECTRONICS CO., LTD.
    Inventors: Chungen Qian, Yuping Zhang
  • Publication number: 20120001136
    Abstract: The present disclosure provides a chemiluminescent composition where the chemiluminescent substrate is 1,2-dioxetane, which contains 1,2-dioxetane and an alkyl dimethyl benzyl quaternary ammonium salt having the structure of general formula I. The present disclosure also provides an enhancing reagent and methods for enhancing chemiluminescence of 1,2-dioxetane, where the enhancing reagent contains an alkyl dimethyl benzyl quaternary ammonium salt having the structure of general formula I.
    Type: Application
    Filed: June 29, 2011
    Publication date: January 5, 2012
    Applicant: Shenzhen Mindray Bio-Medical Electronics Co., Ltd.
    Inventors: Chungen Qian, Yuping Zhang
  • Publication number: 20120003753
    Abstract: A enhancing reagent for enhancing chemiluminescence of 1,2-dioxetane compounds and a method for using the enhancing reagent to enhance chemiluminescence are provided, in which the enhancing reagent contains a multi-alkyl quaternary ammonium salt of Formula I. A chemiluminescent composition with a 1,2-dioxetane compound as a substrate and a kit thereof are further provided, which contain a 1,2-dioxetane compound and a multi-alkyl quaternary ammonium salt of Formula I.
    Type: Application
    Filed: June 29, 2011
    Publication date: January 5, 2012
    Applicant: SHENZHEN MINDRAY BIO-MEDICAL ELECTRONICS CO., LTD.
    Inventors: Chungen Qian, Yuping Zhang
  • Publication number: 20110300602
    Abstract: Methods for preparing conjugates including enzyme conjugates and especially alkaline phosphatase (ALP) conjugates, and a kit are provided. The methods include: blocking an amino group on a molecule surface of a first substance to be conjugated containing an amino group and a carboxyl group (for example, an enzyme) with a carboxyl compound; adding a carbodiimide to activate the first substance to be conjugated with the amino group blocked; inactivating or removing the carbodiimide; and adding a second substance containing an amino group (for example, a substance to be labeled). Conjugates (for example, enzyme conjugates) are obtained.
    Type: Application
    Filed: June 2, 2011
    Publication date: December 8, 2011
    Applicant: Shenzhen Mindray Bio-Medical Electronics Co., Ltd.
    Inventors: Chungen Qian, Ke Li, Yuping Zhang
  • Publication number: 20110300601
    Abstract: Methods for synthesizing an ALP conjugate are provided. The methods may include activating a carboxyl group of the ALP with a carbodiimide, to generate an active ester; and adding the substance to be conjugated such that a synthetic reaction occurs between the active ester and the substance to be conjugated, to generate an ALP conjugate.
    Type: Application
    Filed: June 2, 2011
    Publication date: December 8, 2011
    Applicant: Shenzhen Mindray Bio-Medical Electronics Co., Ltd.
    Inventors: Chungen Qian, Ke Li, Yuping Zhang
  • Publication number: 20110159565
    Abstract: The present disclosure relates to stabilizers for alkaline phosphatase or conjugates thereof, a process for preparing a stabilizer, and a method for stabilizing alkaline phosphatase or conjugates thereof with a stabilizer. The present disclosure also relates to a reagent of alkaline phosphatase or conjugates thereof as well as to a process for preparing the same. In another aspect, the present disclosure relates to a kit comprising the stabilizers disclosed herein and alkaline phosphatase or conjugates thereof. The stabilizer disclosed herein can stabilize alkaline phosphatase or conjugates thereof for a prolonged period of time, extending their shelf-life.
    Type: Application
    Filed: December 29, 2010
    Publication date: June 30, 2011
    Applicant: SHENZHEN MINDRAY BIO-MEDICAL ELECTRONICS CO., LTD.
    Inventors: Chungen QIAN, Yuping ZHANG