Abstract: Provided are a chemiresistor and a method of manufacturing the same, a chemiresistive sensor, and a device. The chemiresistor includes a conductive porous nanocomposite of a three-dimensional metal-organic framework and a two-dimensional metal-organic framework, wherein the two-dimensional metal-organic framework is chemically bound to the three-dimensional metal-organic framework on a surface of the three-dimensional metal-organic framework, and the three-dimensional metal-organic framework and the two-dimensional metal-organic framework form a core-shell structure in the conductive porous nanocomposite.