Abstract: The present invention relates to the field of optical calibration equipment for gene sequencers and discloses a gene sequencer optical calibration system and method, including a control module and a light-emitting calibration module. The light-emitting calibration module is used to simulate the genes measured by a gene sequencer, and the control module is used to control the light-emitting calibration module. The light-emitting calibration module is electrically connected to the control module. The light-emitting calibration module comprises a light-emitting unit and a calibration unit. The light-emitting unit uses multiple OLED screens as the light source. The calibration unit has correction masks for calibration purposes, and the calibration unit is mounted above the light-emitting unit.

Abstract: The present invention provides a B7-H3 nanobody, the preparation method and use thereof. The B7-H3 nanobody comprises framework regions 1-4 (FR 1-4) and complementarity determining regions 1-3 (CDR 1-3), can specifically bind to B7-H3, and can be used for detecting B7-H3 molecules, and be used for the treatment of various malignant tumors with abnormal expression of B7-H3 molecule.

Abstract: Provided is use of an NGF antibody in CIPN pain. In particular, the NGF antibody blocks the interaction of nerve growth factors (NGF) with receptors thereof, and thus can treat and/or prevent chemotherapy-induced peripheral neuropathy (CIPN) pain.

Abstract: Provided are an intermediate (connexon and load combination) for preparing an antibody-drug conjugate (ADC), a preparation method therefor, and the use thereof. The connexon and load combination has a structure as represented by formula I. Formula I can be used for coupling highly hydrophobic compound loads, such as paclitaxel (PTX’), and a prepared ADC molecule has good hydrophilicity and thermal stability and can achieve a higher drug-to-antibody ratio.

Abstract: A method is provided for updating a virtual application attribute. The method includes, in a running process of a virtual application client, obtaining, by a computing device, a first event resource that is in a temporary state and that is generated by executing a first event by a first account of the virtual application client; converting, by the computing device, a second event resource that is in the temporary state and that is obtained before the first event resource into the second event resource in a normal state; adding, by the computing device, the second event resource to event resources that are in the normal state and that have been obtained previously; and, when a predetermined operation performed on the event resources in the normal state is detected, updating, by the computing device, a virtual application attribute of the first account in the virtual application client.

Abstract: Methods and compositions are provided which confer protection against autoimmune diseases without triggering intracellular estrogen receptors. Such methods and compositions limit the side effects of steroids while providing the benefits conferred by such medications through the activation of membrane estrogen receptors.

Abstract: Disclosed herein are several methods for promoting nerve regeneration. The methods include administering at least one tyrphostin, or a pharmaceutically acceptable salt thereof. In one non-limiting example, the tyrphostin is tyrphostin A9. These methods can be used to promote nerve growth in the central or peripheral nervous system. The methods are of use in treating neurodegenerative diseases, such as Parkinson's disease, or in treating the transaction of a partial or complete transaction of a nerve in the peripheral or central nervous system.