Abstract: Use of an MSC in improving thrombotic complications in COVID-19 pneumonia. Provided is an ACE2-negative MSC; an intravenous injection of the MSC is safe and efficacious for critical and severe COVID-19 patients. The ACE2-negative MSC promotes organ injury repairing by means of immunomodulation. Also discovered is that the MSC is capable of upregulating the expression of kindlin-3 in immune cells, thus upregulating integrin signaling in the immune cells, and inhibiting the release of neutrophil extracellular traps (NETs) in a COVID-19 patient. This favors an improvement on thrombotic complications in COVID-19 pneumonia.

Abstract: Disclosed are a heterogeneous stem cell population, a preparation method therefor, and the use thereof. Specifically, disclosed is a heterogeneous stem cell population, characterized in that stem cells in the heterogeneous stem cell population express stemness genes MYC, KLF4, GMNN, SOX2 and NANOG, and in the heterogeneous stem cell population, the ratio of stem cells expressing CD146 is 1%-50%.

Abstract: Provided are a sub-totipotent stem cell product and epigenetic modification label thereof, a method for inducing the generation of the sub-totipotent stem cell product and identification for the epigenetic modification label of the differentiation potential of stem cells. Also provided is a use of histone modification states of sub-totipotent genes and/or differentiation related genes to predict the epigenetic modification label of the differentiation potentials of stem cells.

Abstract: Provided are a sub-totipotent stem cell product and epigenetic modification label thereof, a method for inducing the generation of the sub-totipotent stem cell product and identification for the epigenetic modification label of the differentiation potential of stem cells. Also provided is a use of histone modification states of sub-totipotent genes and/or differentiation related genes to predict the epigenetic modification label of the differentiation potentials of stem cells.

Abstract: This invention relates to a method and apparatus for the control of injection molding and, in particular, for determining a suitable time for transfer from injection velocity control to packing pressure control. The invention uses a derivative of, preferably the nozzle pressure, and inputs this to a fuzzy inference system. The fuzzy inference system uses said rules and knowledge to provide a suitable transfer time as an output. It is preferred that the sample pressure is filtered prior to calculation of the derivative.