Patents by Inventor Chunhui (Chris) Xu
Chunhui (Chris) Xu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11112594Abstract: A microendoscope, and a microendoscopy method related to the microendoscope, each include a tube housing, where an end of the tube housing is shaped and finished to facilitate collection of light emitted from a sample when examined using the microendoscope. In addition, a catadioptric lens assembly, an endomicroscope that includes the catadioptric lens assembly and a microendoscopy method for microscopic analysis that uses the endomicroscope are predicated upon a second element and a third element within the catadioptric lens assembly that each has a dichroic coating. The placement of the dichroic coating on the second element and the third element provides for different magnification factors as a function of illumination wavelength when using the microendoscopy method.Type: GrantFiled: May 10, 2013Date of Patent: September 7, 2021Assignee: CORNELL UNIVERSITYInventors: Dimitre G Ouzounov, Chunhui (Chris) Xu, Watt W. Webb
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Patent number: 9375136Abstract: An optical lens comprising a lens body that transmits light in an optical path there through, wherein the lens body consists of an anterior surface, a posterior surface, and a medium there between, further wherein one of the anterior surface and the posterior surface has a single curvature and the other of the anterior surface and the posterior surface has at least two optical zones each having a different curvature. An optical system, comprising a multi-photon endoscope having a distal end, and the optical lens disposed in the distal end. A method for obtaining an image of an object comprising providing the multi-photon endoscope, propagating light from the endoscope scanner one optical zone of the lens to focus the light at a focus location, and propagating light from the scanner through a different optical zones of the lens to focus the light at a different focus location.Type: GrantFiled: January 24, 2011Date of Patent: June 28, 2016Assignee: CORNELL UNIVERSITYInventors: Watt W. Webb, Chunhui (Chris) Xu, Minghan Chen
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Patent number: 9195042Abstract: Embodied is a two-color, fiber-delivered picosecond source for coherent Raman scattering (CRS) imaging. A wavelength tunable picosecond pump is generated by nonlinear spectral compression of a prechirped femtosecond pulse from a mode-locked titanium:sapphire (Ti:S) laser. A 1064-nm picosecond Stokes pulse is generated by an all-fiber time-lens source (or suitable alternative source) that is synchronized to the Ti:S laser. The pump and Stokes beams are combined in an optical fiber coupler, which serves not only as the delivery fiber but also as the nonlinear medium for spectral compression of the femtosecond pulse. CRS imaging of mouse skin is performed to demonstrate the practicality of this source.Type: GrantFiled: October 1, 2012Date of Patent: November 24, 2015Assignee: CORNELL UNIVERSITYInventors: Chunhui (Chris) Xu, Ke Wang
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Publication number: 20150131147Abstract: A microendoscope, and a microendoscopy method related to the microendoscope, each include a tube housing, where an end of the tube housing is shaped and finished to facilitate collection of light emitted from a sample when examined using the microendoscope. In addition, a catadioptric lens assembly, an endomicroscope that includes the catadioptric lens assembly and a microendoscopy method for microscopic analysis that uses the endomicroscope are predicated upon a second element and a third element within the catadioptric lens assembly that each has a dichroic coating. The placement of the dichroic coating on the second element and the third element provides for different magnification factors as a function of illumination wavelength when using the microendoscopy method.Type: ApplicationFiled: May 10, 2013Publication date: May 14, 2015Applicant: CORNELL UNIVERSITYInventors: Dimitre G Ouzounov, Chunhui (Chris) Xu, Watt W. Webb
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Publication number: 20140240702Abstract: Embodied is a two-color, fiber-delivered picosecond source for coherent Raman scattering (CRS) imaging. A wavelength tunable picosecond pump is generated by nonlinear spectral compression of a prechirped femtosecond pulse from a mode-locked titanium:sapphire (Ti:S) laser. A 1064-nm picosecond Stokes pulse is generated by an all-fiber time-lens source (or suitable alternative source) that is synchronized to the Ti:S laser. The pump and Stokes beams are combined in an optical fiber coupler, which serves not only as the delivery fiber but also as the nonlinear medium for spectral compression of the femtosecond pulse. CRS imaging of mouse skin is performed to demonstrate the practicality of this source.Type: ApplicationFiled: October 1, 2012Publication date: August 28, 2014Applicant: CORNELL UNIVERSITYInventors: Chunhui (Chris) Xu, Ke Wang
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Patent number: 8705184Abstract: An optical scanner, scanner apparatus, or scanner assembly, which may be particularly advantageous for use in a multiphoton microscope, includes a first drivable bending component, a second drivable bending component mounted perpendicularly to the first component, and at least one optical waveguide coupled one or both of the first and second bending components, wherein the at least one optical waveguide provides both a propagation path for a multiphoton excitation radiation delivery between a light source and a target and a multiphoton-induced emission radiation delivery between the target and a detector. A GRIN relay lens. A multiphoton microscope incorporating the scanner and the GRIN relay lens.Type: GrantFiled: December 8, 2011Date of Patent: April 22, 2014Assignee: Cornell UniversityInventors: Chunhui (Chris) Xu, Watt W. Webb, Douglas S. Scherr, Dimitre Gueorguiev Ouzounov, David R. Rivera, Christopher M. Brown, Demirhan Kobat, David Huland, Scott S. Howard
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Publication number: 20130324858Abstract: An optical scanner, scanner apparatus, or scanner assembly, which may be particularly advantageous for use in a multiphoton microscope, includes a first drivable bending component, a second drivable bending component mounted perpendicularly to the first component, and at least one optical waveguide coupled one or both of the first and second bending components, wherein the at least one optical waveguide provides both a propagation path for a multiphoton excitation radiation delivery between a light source and a target and a multiphoton-induced emission radiation delivery between the target and a detector. A GRIN relay lens. A multiphoton microscope incorporating the scanner and the GRIN relay lens.Type: ApplicationFiled: December 8, 2011Publication date: December 5, 2013Applicant: CORNELL UNIVERSITYInventors: Chunhui (Chris) Xu, Watt W. Webb, Douglas S. Scherr, Dimitre Gueorguiev Ouzounov, David R. Rivera, Christopher M. Brown, Demirhan Kobat, David Huland, Scott S. Howard
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Publication number: 20130126756Abstract: A fluorescence emission imaging method and apparatus allows for high frame rate imaging in scattering medium as well as for fluorescence, phosphorescence, or luminescence lifetime imaging, time-resolved fluorescence, phosphorescence, or luminescence lifetime spectroscopy and imaging. A method involves providing an illumination beam, propagating the illumination beam to a light modulator array, modulating the illumination beam so as to generate an array of point sources, wherein each of the point sources is modulated at a frequency, imaging the modulated illumination beam on the object, and detecting a fluorescent, phosphorescent, or luminescent emission from the object. An optical imaging component in the form of a modulation mask has multiple bands. Each band has alternating transmissive and/or reflective and/or absorptive regions that are patterned such that light scanned over a band will be modulated at a band-related frequency.Type: ApplicationFiled: January 24, 2011Publication date: May 23, 2013Applicant: Cornell UniversityInventors: Chunhui (Chris) Xu, Scott Howard, Adam Straub, Guanghao Zhu
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Publication number: 20130006056Abstract: An optical lens comprising a lens body that transmits light in an optical path there through, wherein the lens body consists of an anterior surface, a posterior surface, and a medium there between, further wherein one of the anterior surface and the posterior surface has a single curvature and the other of the anterior surface and the posterior surface has at, least two optical zones each having a different curvature. An optical system, comprising a multi-photon endoscope having a distal end, and the optical lens disposed in the distal end. A method for obtaining an image of an object comprising providing the multi-photon endoscope, propagating light from the endoscope scanner one optical zone of the lens to focus the light at a focus location, and propagating light from the scanner through a different optical zones of the lens to focus the light at a different focus location.Type: ApplicationFiled: January 24, 2011Publication date: January 3, 2013Applicant: Cornell University - Cornell Center for Technology Enterprise & Commercialization (CCTEC)Inventors: Watt W. Webb, Chunhui (Chris) Xu, Minghan Chen
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Publication number: 20120140301Abstract: An optical scanner, scanner apparatus, or scanner assembly, which may be particularly advantageous for use in a multiphoton microscope, includes a first drivable bending component, a second drivable bending component mounted perpendicularly to the first component, and at least one optical waveguide coupled one or both of the first and second bending components, wherein the at least one optical waveguide provides both a propagation path for a multiphoton excitation radiation delivery between a light source and a target and a multiphoton-induced emission radiation delivery between the target and a detector. A GRIN relay lens. A multiphoton microscope incorporating the scanner and the GRIN relay lens.Type: ApplicationFiled: December 8, 2011Publication date: June 7, 2012Applicant: CORNELL UNIVERSITYInventors: Chunhui (Chris) Xu, Watt W. Webb, Douglas S. Scherr, Dimitre Gueorguiev Ouzounov, David R. Rivera, Christopher M. Brown, Demirhan Kobat, David Huland, Scott S. Howard
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Patent number: 8102594Abstract: Methods and systems for compensation of Self-Phase Modulation 35 in fiber-based amplifier systems 20.Type: GrantFiled: April 27, 2007Date of Patent: January 24, 2012Assignee: Cornell UniversityInventors: Chunhui (Chris) Xu, James W. van Howe, Guanghao Zhu
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Publication number: 20090201573Abstract: Methods and systems for compensation of Self-Phase Modulation 35 in fiber-based amplifier systems 20.Type: ApplicationFiled: April 27, 2007Publication date: August 13, 2009Applicant: CORNELL UNIVERSITYInventors: Chunhui (Chris) Xu, James W. van Howe, Guanghao Zhu