Patents by Inventor Chunjiao Wang

Chunjiao Wang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method of sequence optimization for improved recombinant protein expression using a particle swarm optimization algorithm
    Patent number: 8326547
    Abstract: An improved gene sequence optimization method, the systematic optimization method, is described for boosting the recombinant expression of genes in bacteria, yeast, insect and mammalian cells. This general method takes into account of multiple, preferably most or all, of the parameters and factors affecting protein expression including codon usage, tRNA usage, GC-content, ribosome binding sequences, promoter, 5?-UTR, ORF and 3?-UTR sequences of the genes to improve and optimize the gene sequences to boost the protein expression of the genes in bacteria, yeast, insect and mammalian cells. In particular, the invention relates to a system and a method for sequence optimization for improved recombinant protein expression using a particle swarm optimization algorithm. The improved systematic optimization method can be incorporated into a software for more efficient optimization.
    Type: Grant
    Filed: September 30, 2010
    Date of Patent: December 4, 2012
    Assignee: Nanjingjinsirui Science & Technology Biology Corp.
    Inventors: Xiaowu Liu, Yun He, Zhuying Wang, Chunjiao Wang, Zhibing Liu, Tianhui Xia, Luquan Wang, Fang Liang Zhang
  • Method of Sequence Optimization for Improved Recombinant Protein Expression using a Particle Swarm Optimization Algorithm
    Publication number: 20110081708
    Abstract: An improved gene sequence optimization method, the systematic optimization method, is described for boosting the recombinant expression of genes in bacteria, yeast, insect and mammalian cells. This general method takes into account of multiple, preferably most or all, of the parameters and factors affecting protein expression including codon usage, tRNA usage, GC-content, ribosome binding sequences, promoter, 5?-UTR, ORF and 3?-UTR sequences of the genes to improve and optimize the gene sequences to boost the protein expression of the genes in bacteria, yeast, insect and mammalian cells. In particular, the invention relates to a system and a method for sequence optimization for improved recombinant protein expression using a particle swarm optimization algorithm. The improved systematic optimization method can be incorporated into a software for more efficient optimization.
    Type: Application
    Filed: September 30, 2010
    Publication date: April 7, 2011
    Applicant: GENSCRIPT HOLDINGS (HONG KONG) LIMITED
    Inventors: Xiaowu LIU, Yun HE, Zhuying WANG, Chunjiao WANG, Zhibing LIU, Tianhui XIA, Luquan WANG, Fang Liang ZHANG