Patents by Inventor Chunlan Hu

Chunlan Hu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • URATE OXIDASE PREPARATION AND USE THEREOF
    Publication number: 20230346959
    Abstract: Provided is a urate oxidase preparation. The urate oxidase preparation includes polyethylene glycol-modified urate oxidase as an active ingredient and a buffer reagent as an excipient.
    Type: Application
    Filed: May 4, 2023
    Publication date: November 2, 2023
    Applicant: HANGZHOU GRAND BIOLOGIC PHARMACEUTICAL INC.
    Inventors: Yunfeng HE, Zhiming WANG, Zhicheng FU, Yu WANG, Haiyan WEN, Tianwen YAN, Chunlan HU, Guowei SU, Riyong LIU, Xupeng DING, Kai FAN, Hongying WANG, Qian WANG
  • METHOD FOR PREPARING POLYETHYLENE GLYCOL-MODIFIED URATE OXIDASE
    Publication number: 20230346896
    Abstract: Provided is a method for preparing a polyethylene glycol-modified urate oxidase, at least 11 of the following amino acid sites of the polyethylene glycol-modified urate oxidase have a PEG modification: T1, K3, K4, K30, K35, K76, K79, K97, K112, K116, K120, K152, K179, K222, K231, K266, K272, K285, K291, and K293, and the preparation method includes: performing a coupling reaction between urate oxidase and polyethylene glycol, wherein the polyethylene glycol is provided in the form of an acidic solution, and a molar ratio of the urate oxidase to the polyethylene glycol is 1: (56 to 94), to obtain the polyethylene glycol-modified urate oxidase.
    Type: Application
    Filed: May 4, 2023
    Publication date: November 2, 2023
    Applicant: HANGZHOU GRAND BIOLOGIC PHARMACEUTICAL INC.
    Inventors: RIYONG LIU, Zhiming WANG, Yunfeng HE, Yu WANG, Zhicheng FU, Tianwen YAN, Chunlan HU, Guowei SU, Changcheng TAN, Xupeng DING, Hui YANG, Hongying WANG, Qiong DING, Qian WANG, Haiyan WEN, Kai FAN
  • POLYETHYLENE GLYCOL-MODIFIED URATE OXIDASE
    Publication number: 20220054598
    Abstract: The present disclosure provides a polyethylene glycol-modified urate oxidase. At least 11 of the following amino acid sites in the urate oxidase have a PEG modification: T1, K3, K4, K30, K35, K76, K79, K97, K112, K116, K120, K152, K179, K222, K231, K266, K272, K285, K291, and K293.
    Type: Application
    Filed: November 9, 2021
    Publication date: February 24, 2022
    Inventors: Kai FAN, Zhiming WANG, Riyong LIU, Yu WANG, Yunfeng HE, Tianwen YAN, Zhicheng FU, Guowei SU, Chunlan HU, Xupeng DING, Changcheng TAN, Hongying WANG, Hui YANG, Qiong DING, Haiyan WEN
  • Pegylated analogue protein or canine urate oxidase, preparation method and use thereof
    Patent number: 9193967
    Abstract: Provided are a PEGylated analogue protein of canine urate oxidase, preparation method and use thereof. The analogue protein of canine urate oxidase is a canine urate oxidase, or a chimeric protein comprising part of the amino acid sequence of a canine urate oxidase and part of the amino acid sequence of a human urate oxidase, or a mutant protein thereof. The PEGylated analogue protein of canine urate oxidase and pharmaceutical compositions thereof according to the present invention can be used for the prevention and/or treatment of hyperuricemia and chronic gout.
    Type: Grant
    Filed: February 14, 2012
    Date of Patent: November 24, 2015
    Inventors: Chun Zhang, Kai Fan, Xuefeng Ma, Li Yang, Chunlan Hu, Hua Luo, Xiang Mei
  • PEGYLATED ANALOGUE PROTEIN OR CANINE URATE OXIDASE, PREPARATION METHOD AND USE THEREOF
    Publication number: 20140065123
    Abstract: Provided are a PEGylated analogue protein of canine urate oxidase, preparation method and use thereof. The analogue protein of canine urate oxidase is a canine urate oxidase, or a chimeric protein comprising part of the amino acid sequence of a canine urate oxidase and part of the amino acid sequence of a human urate oxidase, or a mutant protein thereof. The PEGylated analogue protein of canine urate oxidase and pharmaceutical compositions thereof according to the present invention can be used for the prevention and/or treatment of hyperuricemia and chronic gout.
    Type: Application
    Filed: February 14, 2012
    Publication date: March 6, 2014
    Applicant: Chongqing Fagen Biomedical Inc. No. 80 4th Street Keyuan
    Inventors: Chun Zhang, Kai Fan, Xuefeng Ma, Li Yang, Chunlan Hu, Hua Luo, Xiang Mei
  • Humanized recombinant uricase and mutants thereof
    Patent number: 8586535
    Abstract: The present invention provides a humanized recombinant uricase and mutants thereof, wherein the humanized recombinant uricase is a chimeric protein which comprises amino acids of non-human mammal uricase and amino acids of human uricase. The humanized recombinant unease and mutants thereof have reduced immunogenicity in human, and can be used for the treatment of hyperuricemia and gout.
    Type: Grant
    Filed: March 12, 2010
    Date of Patent: November 19, 2013
    Assignee: Chongqing Fagen Biomedical Inc.
    Inventors: Kai Fan, Chun Zhang, Xuefeng Ma, Xiang Mei, Chunlan Hu
  • HUMANIZED RECOMBINANT URICASE AND MUTANTS THEREOF
    Publication number: 20120269795
    Abstract: The present invention provides a humanized recombinant uricase and mutants thereof, wherein the humanized recombinant uricase is a chimeric protein which comprises amino acids of non-human mammal uricase and amino acids of human uricase. The humanized recombinant unease and mutants thereof have reduced immunogenicity in human, and can be used for the treatment of hyperuricemia and gout.
    Type: Application
    Filed: March 12, 2010
    Publication date: October 25, 2012
    Applicant: Congqing Fagen Biomedical Inc.
    Inventors: Kai Fan, Chun Zhang, Xuefeng Ma, Xiang Mei, Chunlan Hu