Abstract: The subject invention is concerned with systems and methods advantageously applying finite element analysis to establish design rules for a highly sensitive piezo-resistive pressure sensor with an output that is high enough to be detectable by simple and inexpensive circuits and therefore ensure wearability. Four frequently reported micro-feature shapes in micro-patterned piezo-resistive sensors are provided, where the micro-dome and micro-pyramid yield the highest sensitivity. Investigations of different conductivity values of micro-patterned elastomers show that coating the elastomer with a conductive material (e.g., a metallic coating) leads to higher current response when compared to composited conductive elastomers. Advantageous geometric parameters and spatial configurations of micro-pyramid design of piezo-resistive sensors are provided.

Abstract: A method for estimating the strength of a laser welded blank including a first blank and a second blank joined together by a weld seam. The method may include forming a plurality of indentations in the first blank, the second blank, and the weld seam to determine an average value of a micro-hardness (Vickers); determining a scale-up ratio K; multiplying the scale-up ratio K by the average values of the micro-hardness of each of the first blank, the second blank, and the weld seam to obtain a scaled-up average value of the microhardness of each of the first blank, the second blank, and the weld seam; running a finite elemental analysis (FEA) simulation using the scaled-up average values of the microhardness; and based on the results of the simulation, determining whether the strength of the laser welded blank is sufficient to withstand being subjected to a forming process.

Abstract: A dimming module and method for manufacturing the same, and a dimming glass, relate to the field of smart glass technology. The dimming module includes: a first dimming structure (10) and a second dimming structure (20). Each of the first dimming structure (10) and the second dimming structure (20) includes a first substrate (1), a second substrate (2) and a liquid crystal layer (3), and a first flexible circuit board (4) and a second flexible circuit board (5). The first substrate (1) is provided with a first binding area (11), and a first electrode (6) on one side facing the liquid crystal layer (3). The second substrate (2) is provided with a second binding area (21), and a plurality of second electrodes (7) on one side facing the liquid crystal layer (3).

Abstract: A light adjustment device includes a first substrate and a second substrate that are arranged opposite to each other, a light adjustment module, and an ultraviolet light blocking layer. The light adjustment module is located between the first substrate and the second substrate. The ultraviolet light blocking layer is located between the first substrate and the light adjustment module or located inside the light adjustment module. A refractive index of the ultraviolet light blocking layer is greater than a refractive index of the first substrate.

Abstract: The present disclosure provides a dimming glass and a method for manufacturing the dimming glass. The dimming glass includes: at least one dimming functional layer sandwiched between two glass substrates, where a plurality of conductive leads is connected to a bonding circuit board, and a sealant filled between sealant regions of the two glass substrates. Each conductive lead includes a connecting end, a protruding end and an extension segment. The connecting end is connected to the bonding circuit board, the protruding end extends out of an outer side of an edge of the glass substrate, at least a part of the extension segment extends in a first direction which is an extension direction of an edge of the bonding side of the dimming functional layer, and the extension segment is located in the sealant region and is secured through the sealant.

Abstract: A light-adjusting glass is provided to include: a first toughened glass layer, a first adhesive layer, a first substrate, a second substrate, a second adhesive layer, a second toughened glass layer and supporting spacers between the first and second substrates, which are sequentially stacked; materials of the first and second adhesive layers are melted under the conditions that a temperature is in a range of 130° C. to 150° C. and a pressure is in a range of 12 bar to 14 bar, and are solidified after being cooled; the light-adjusting glass further includes an edge sealing structure around the first and second substrates, and the edge sealing structure, the first and second substrates are enclosed to form a gap filled with a liquid crystal; the edge sealing structure includes a liquid crystal pouring port therein; a sealing glue is at an opening of the liquid crystal pouring port and seals the opening.

Abstract: There is provided a light adjusting structure, a light adjusting module and a light adjusting device, the light adjusting structure includes one or two light adjusting functional layers stacked, each light adjusting functional layer includes functional sub-layers in different regions, first substrates and/or second substrates of the functional sub-layers constitute a full-layer planar substrate, one of first electrodes or second electrodes of the functional sub-layers are disposed at an interval, and the other one of the first electrodes or the second electrodes are disposed at an interval or constitute a full-layer planar electrode; dye liquid crystal layers of the functional sub-layers each include a sealant between the first alignment layer and the second alignment layer, and dye molecules and liquid crystal molecules in a space surrounded by the sealant; sealants of the functional sub-layers are disposed at an interval, and spaces surrounded by the sealants are isolated.

Abstract: Provided herein are multispecific antibodies containing a lambda charge pair introduced into the interface of a heavy chain and a light chain to reduce chain mispairing.

Abstract: The present disclosure provides a dimming glass and a method for manufacturing the dimming glass. The dimming glass includes: at least one dimming functional layer sandwiched between two glass substrates, where a plurality of conductive leads is connected to a bonding circuit board, and a sealant filled between sealant regions of the two glass substrates. Each conductive lead includes a connecting end, a protruding end and an extension segment. The connecting end is connected to the bonding circuit board, the protruding end extends out of an outer side of an edge of the glass substrate, at least a part of the extension segment extends in a first direction which is an extension direction of an edge of the bonding side of the dimming functional layer, and the extension segment is located in the sealant region and is secured through the sealant.

Abstract: A dimming window and a manufacturing method thereof, belong to the technical field of dimming glass. The dimming window includes: at least two chambers arranged in a stack, each of the chambers comprising two light-transmitting substrates arranged opposite to each other; the at least two chambers include a first chamber and a second chamber, a dinning structure is provided in the first chamber, and a first reflective film is provided in the first chamber and/or the second chamber; wherein the thickness of the second chamber is greater than or equal to the thickness of the first chamber, and the thickness of the chamber is a distance between two opposite surfaces of the two light-transmitting substrates of the chamber. The technical solution of the present disclosure can improve the shading effect of the dimming window.

Abstract: The subject invention is concerned with systems and methods advantageously applying finite element analysis to establish design rules for a highly sensitive piezo-resistive pressure sensor with an output that is high enough to be detectable by simple and inexpensive circuits and therefore ensure wearability. Four frequently reported micro-feature shapes in micro-patterned piezo-resistive sensors are provided, where the micro-dome and micro-pyramid yield the highest sensitivity. Investigations of different conductivity values of micro-patterned elastomers show that coating the elastomer with a conductive material (e.g., a metallic coating) leads to higher current response when compared to composited conductive elastomers. Advantageous geometric parameters and spatial configurations of micro-pyramid design of piezo-resistive sensors are provided.

Abstract: Provided herein is a multispecific antibody containing two antigen binding arms capable of binding to a first target and at least one antigen binding arm capable of binding to a second target. The multispecific antibody includes a lambda charge pair introduced into the interface of a heavy chain and a light chain to reduce chain mispairing.

Abstract: Provided herein are trispecific antibodies containing three antigen binding arms each capable of binding to a different target, wherein each antigen binding arm contains a different lambda or kappa charge pair introduced into the interface of the respective heavy and light chains to reduce chain mispairing.

Abstract: This disclosure provides methods and apparatuses for providing interpretability for multivariate time-series data anomaly detection. The multivariate time-series data anomaly detection is performed, through a multivariate time-series data anomaly detection model, for a multivariate time-series data formed by multiple time-series data. An anomaly detection result indicating at least an anomaly period is obtained from the model. An anomaly period correlation metric of the multiple time-series data in the anomaly period is determined. A trace-back period correlation metric of the multiple time-series data in a trace-back period before the anomaly period is determined. At least one time-series data pair having abnormal correlation in the anomaly period is identified from the multiple time-series data, based on a difference between the anomaly period correlation metric and the trace-back period correlation metric.

Abstract: A multifunctional rotating control device (RCD) is provided. The multifunctional RCD includes an RCD assembly and a flow detection module. Further, the RCD assembly includes a body and a rotating sealing assembly. A bore through hole and a bypass outlet are formed in the body, and the rotating sealing assembly is provided in the bore through hole. Additionally, the bypass outlet is connected to a straight-through cut-off valve, and the flow detection module includes a flowmeter, a first flow cut-off valve, and a second flow cut-off valve. Further, the flowmeter extends upward in a direction of the bore through hole, and the first flow cut-off valve and the second flow cut-off valve are respectively provided at two ends of the flowmeter, and communicate with the flowmeter. Additionally, an inlet of the flowmeter is a flow detection input outlet, and the flow detection input outlet communicates with the straight-through cut-off valve.

Abstract: Biosensors capable of detecting certain biomarkers (e.g., platelet-derived growth factor-BB (PDGF-BB)), as well as methods of fabricating the same and methods of using the same, are provided. The biosensors can be disposable and/or label-free. Electrochemical bipolar exfoliation can be used to exfoliate, reduce, and deposit (in a single step) graphene nanosheets on a desired substrate (e.g., an electrode). Affinity aptamers can be immobilized on the graphene nanosheets disposed on the substrate.

Abstract: A multifunctional rotating control device (RCD) includes an RCD assembly, a multi-way cross, and choke control modules. The RCD assembly includes a body and a rotating sealing assembly, where a bore through hole, two side outlets, and a straight-through outlet are formed in the body. The rotating sealing assembly is provided in the bore through hole, a straight-through cut-off valve is provided at the straight-through outlet, and there are two choke control modules. The two choke control modules are respectively connected to the two side outlets and the multi-way cross, and a side choke extends upward in a direction of the bore through hole. The two choke control modules are integrated onto the RCD assembly, and extend upward in the direction of the bore through hole.

Abstract: A light-adjusting structure, a method for manufacturing the light-adjusting structure, and a light-adjusting module are provided, which belong to the field of display technology, the light-adjusting structure includes: a first flexible substrate and a second flexible substrate oppositely arranged; a first transparent electrode and a second transparent electrode which are located between the first flexible substrate and the second flexible substrate; a first alignment layer located on a side of the first flexible substrate facing towards the second flexible substrate; a second alignment layer located on a side of the second flexible substrate facing towards the first flexible substrate; and a spacer and a dye liquid crystal layer which are located between the first alignment layer and the second alignment layer. The solutions of the present disclosure can meet light-adjusting requirements of vehicle windows.

Abstract: The subject invention is concerned with systems and methods advantageously applying finite element analysis to establish design rules for a highly sensitive piezo-resistive pressure sensor with an output that is high enough to be detectable by simple and inexpensive circuits and therefore ensure wearability. Four frequently reported micro-feature shapes in micro-patterned piezo-resistive sensors are provided, where the micro-dome and micro-pyramid yield the highest sensitivity. Investigations of different conductivity values of micro-patterned elastomers show that coating the elastomer with a conductive material (e.g., a metallic coating) leads to higher current response when compared to composited conductive elastomers. Advantageous geometric parameters and spatial configurations of micro-pyramid design of piezo-resistive sensors are provided.

Abstract: Biosensors capable of detecting certain biomarkers (e.g., platelet-derived growth factor-BB (PDGF-BB)), as well as methods of fabricating the same and methods of using the same, are provided. The biosensors can be disposable and/or label-free. Electrochemical bipolar exfoliation can be used to exfoliate, reduce, and deposit (in a single step) graphene nanosheets on a desired substrate (e.g., an electrode). Affinity aptamers can be immobilized on the graphene nanosheets disposed on the substrate.