Patents by Inventor Chunlin Tao

Chunlin Tao has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20180170942
    Abstract: Contemplated compounds, compositions and methods are directed to Ral GTPase inhibitors with improved activity.
    Type: Application
    Filed: June 16, 2016
    Publication date: June 21, 2018
    Inventors: Chunlin Tao, Chengzhi Yu, Tulay Polat, Chao Yan, Shahrooz Rabizadeh, Daniel Theodorescu
  • Publication number: 20180155327
    Abstract: The present invention provides antitumor agents comprising substituted pyrimidine derivatives and pharmaceutically-acceptable formulations thereof, methods for making novel compounds and methods for using the compounds. The compounds and compositions in accordance with the invention have utility in treatment of a variety of diseases and have kinase inhibitory activities.
    Type: Application
    Filed: February 27, 2015
    Publication date: June 7, 2018
    Inventors: Chunlin Tao, Qinwei Wang, Laxman Nallan, David Ho, Tulay Polat, Forrest Arp, Paul Weingarten
  • Publication number: 20180086752
    Abstract: Compounds and compositions are presented that inhibit K-ras, and especially mutant K-ras. Certain compounds preferentially or even selectively inhibit specific forms of mutant K-Ras, and particularly the G12D mutant form.
    Type: Application
    Filed: April 1, 2016
    Publication date: March 29, 2018
    Inventors: Shahrooz Rabizadeh, Kayvan Niazi, Sasha Buzko, Paul Weingarten, Heather McFarlane, Anna Juncker-Jensen, Justin Golovato, Patrick Soon-Shiong, Chunlin Tao, David Ho
  • Publication number: 20170203012
    Abstract: The invention provides a medical device comprising a hydrophobic analog of a medicament known to inhibit cell proliferation and migration. The invention also provides a method of treating a narrowing in a body passageway comprising placing an implantable medical device comprising a hydrophobic analog of a medicament known to inhibit cell proliferation and migration. The medicaments can be incorporated within or coated on the device. The invention further provides hydrophobic analogs of medicaments known to inhibit cell proliferation and migration.
    Type: Application
    Filed: March 31, 2017
    Publication date: July 20, 2017
    Inventors: Neil P. Desai, Chunlin Tao, Cheng Zhi Yu, Qinwei Wang, Patrick Soon-Shiong
  • Publication number: 20170189400
    Abstract: The present invention relates generally to the use of compounds to treat a variety of disorders, diseases and pathologic conditions and more specifically to the use of substituted indol-5-ol derivatives to modulate protein kinases and for treating protein kinase-mediated diseases.
    Type: Application
    Filed: December 15, 2016
    Publication date: July 6, 2017
    Inventor: Chunlin Tao
  • Publication number: 20170172975
    Abstract: The present invention provides compositions comprising nanoparticles comprising: 1) a drug, such as a hydrophobic drug derivative; and 2) a carrier protein. Also provided are methods of treating diseases (such as cancer) using the compositions, as well as kits and unit dosages.
    Type: Application
    Filed: November 29, 2016
    Publication date: June 22, 2017
    Inventors: Neil P. DESAI, Chunlin TAO, Tapas DE, Sherry Xiaopei CI, Vuong TRIEU
  • Publication number: 20170135992
    Abstract: The invention relates generally to the creation and use of cyclic sulfonamide containing derivatives to inhibit the hedgehog signaling pathway and to the use of those compounds for the treatment of hyperproliferative diseases and angiogenesis mediated diseases.
    Type: Application
    Filed: November 22, 2016
    Publication date: May 18, 2017
    Inventors: Chunlin Tao, Chengzhi Yu, Forrest Arp, Paul Weingarten, Patrick Soon-Shiong
  • Publication number: 20170088544
    Abstract: The present invention relates generally to the use of compounds to treat a variety of disorders, diseases and pathologic conditions and more specifically to the use of substituted indol-5-ol derivatives to modulate protein kinases and for treating protein kinase-mediated diseases.
    Type: Application
    Filed: October 4, 2016
    Publication date: March 30, 2017
    Inventors: Chunlin Tao, Qinwei Wang, David Ho, Tulay Polat, Laxman Nallan, Patrick Soon-Shiong
  • Patent number: 9550760
    Abstract: The present invention relates generally to the use of compounds to treat a variety of disorders, diseases and pathologic conditions and more specifically to the use of substituted indol-5-ol derivatives to modulate protein kinases and for treating protein kinase-mediated diseases.
    Type: Grant
    Filed: March 17, 2014
    Date of Patent: January 24, 2017
    Assignee: NantBioScience, Inc.
    Inventor: Chunlin Tao
  • Patent number: 9499539
    Abstract: The invention relates generally to the creation and use of cyclic sulfonamide containing derivatives to inhibit the hedgehog signaling pathway and to the use of those compounds for the treatment of hyperproliferative diseases and angiogenesis mediated diseases.
    Type: Grant
    Filed: November 4, 2013
    Date of Patent: November 22, 2016
    Assignee: NantBioScience, Inc.
    Inventors: Chunlin Tao, Chengzhi Yu, Forrest Arp, Paul Weingarten, Patrick Soon-Shiong
  • Patent number: 9458137
    Abstract: The present invention relates generally to the use of compounds to treat a variety of disorders, diseases and pathologic conditions and more specifically to the use of substituted indol-5-ol derivatives to modulate protein kinases and for treating protein kinase-mediated diseases.
    Type: Grant
    Filed: November 5, 2013
    Date of Patent: October 4, 2016
    Assignee: NantBioScience, Inc.
    Inventors: Chunlin Tao, Qinwei Wang, David Ho, Tulay Polat, Laxman Nallan, Patrick Soon-Shiong
  • Patent number: 9409903
    Abstract: The invention provides triazine compounds and methods of their use to modulate protein kinases and to treat diseases mediated by said protein kinases.
    Type: Grant
    Filed: November 3, 2014
    Date of Patent: August 9, 2016
    Assignee: NantBioScience, Inc.
    Inventors: Chunlin Tao, Qinwei Wang, David Ho, Laxman Nallan, Tulay Polat, Xiaowen Sun, Neil Desai
  • Patent number: 9345699
    Abstract: The invention provides isoquinoline, quinoline, and quinazoline derivatives to treat a variety of disorders, diseases and pathologic conditions, and more specifically to the use of isoquinoline, quinoline, and quinazoline derivatives to inhibit the hedgehog signaling pathway and to the use of those compounds to the treatment of hyperproliferative diseases and pathologic angiogenesis.
    Type: Grant
    Filed: June 9, 2010
    Date of Patent: May 24, 2016
    Assignee: NantBioScience, Inc.
    Inventors: Chunlin Tao, Xiaowen Sun, Hongna Han, Lukasz Koroniak, Neil Desai
  • Publication number: 20160016945
    Abstract: The present invention relates generally to the use of compounds to treat a variety of disorders, diseases and pathologic conditions and more specifically to the use of substituted indol-5-ol derivatives to modulate protein kinases and for treating protein kinase-mediated diseases.
    Type: Application
    Filed: March 17, 2014
    Publication date: January 21, 2016
    Inventor: Chunlin Tao
  • Publication number: 20150299190
    Abstract: The invention relates generally to the creation and use of cyclic sulfonamide containing derivatives to inhibit the hedgehog signaling pathway and to the use of those compounds for the treatment of hyperproliferative diseases and angiogenesis mediated diseases.
    Type: Application
    Filed: November 4, 2013
    Publication date: October 22, 2015
    Inventors: Chunlin Tao, Chengzhi Yu, Forrest Arp, Paul Weingarten, Patrick Soon-Shiong
  • Publication number: 20150291564
    Abstract: The present invention relates generally to the use of compounds to treat a variety of disorders, diseases and pathologic conditions and more specifically to the use of substituted indol-5-ol derivatives to modulate protein kinases and for treating protein kinase-mediated diseases.
    Type: Application
    Filed: November 5, 2013
    Publication date: October 15, 2015
    Applicant: NantBioScience, Inc.
    Inventors: Chunlin Tao, Qinwei Wang, David Ho, Tulay Polat, Laxman Nallan, Patrick Soon-Shiong
  • Patent number: 9078902
    Abstract: The invention provides Triazine derivatives and further provides methods of using these compounds to modulate protein kinases and for treating diseases and conditions mediated by protein kinases.
    Type: Grant
    Filed: June 9, 2010
    Date of Patent: July 14, 2015
    Assignee: NantBioScience, Inc.
    Inventors: Chunlin Tao, Qinwei Wang, Laxman Nallan, Tulay Polat, David Ho, Neil Desai
  • Publication number: 20150190556
    Abstract: The invention provides a medical device comprising a hydrophobic analog of a medicament known to inhibit cell proliferation and migration. The invention also provides a method of treating a narrowing in a body passageway comprising placing an implantable medical device comprising a hydrophobic analog of a medicament known to inhibit cell proliferation and migration. The medicaments can be incorporated within or coated on the device. The invention further provides hydrophobic analogs of medicaments known to inhibit cell proliferation and migration.
    Type: Application
    Filed: March 20, 2015
    Publication date: July 9, 2015
    Inventors: Neil P. Desai, Chunlin Tao, Cheng Zhi Yu, Qinwei Wang, Patrick Soon-Shiong
  • Publication number: 20150111960
    Abstract: In accordance with the present invention, there are provided compositions and methods useful for the in vivo delivery of substantially water insoluble pharmacologically active agents (such as the anticancer drug paclitaxel) in which the pharmacologically active agent is delivered in the form of suspended particles coated with protein (which acts as a stabilizing agent). In particular, protein and pharmacologically active agent in a biocompatible dispersing medium are subjected to high shear, in the absence of any conventional surfactants, and also in the absence of any polymeric core material for the particles. The procedure yields particles with a diameter of less than about 1 micron. The use of specific composition and preparation conditions (e.g., addition of a polar solvent to the organic phase), and careful selection of the proper organic phase and phase fraction, enables the reproducible production of unusually small nanoparticles of less than 200 nm diameter, which can be sterile-filtered.
    Type: Application
    Filed: October 2, 2014
    Publication date: April 23, 2015
    Inventors: Neil P. DESAI, Chunlin TAO, Andrew YANG, Leslie LOUIE, Patrick SOON-SHIONG
  • Publication number: 20150057285
    Abstract: The invention provides triazine compounds and methods of their use to modulate protein kinases and to treat diseases mediated by said protein kinases.
    Type: Application
    Filed: November 3, 2014
    Publication date: February 26, 2015
    Inventors: Chunlin Tao, Qinwei Wang, David Ho, Laxman Nallan, Tulay Polat, Xiaowen Sun, Neil Desai