Abstract: The invention relates to a method for producing cationized cellulose. The method comprises at least preparing a slurry of a cellulosic starting material in an alkaline liquid medium which comprises an organic liquid and performing mercerization of the slurry. The concentration of the cellulosic starting material in the slurry is at least 20 weight-%, calculated as dry from total weight of the liquid medium and the cellulosic starting material. A cationizing agent is added to the slurry after the mercerization step at a cationization temperature, which is less than the boiling point of the alkaline liquid medium, and the cellulose in the slurry is allowed to react with the cationizing agent, preferably under inert atmosphere and a cationized cellulose product is obtained.

Abstract: The present application discloses a PEGylated asparaginase and use thereof. In this application, the polyethylene glycol (PEG) is coupled to the N-terminal amino of 1 or 2 subunits of L-asparaginase, and the molecular weight of the PEG is 30-40 KDa. The PEG is preferably branched and has an aldehyde serving as an activating group. The PEGylated asparaginase is useful in the preparation of anti-tumor drugs.

Abstract: The present application discloses a PEGylated asparaginase and use thereof. In this application, the polyethylene glycol (PEG) is coupled to the N-terminal amino of 1 or 2 subunits of L-asparaginase, and the molecular weight of the PEG is 30-40 KDa. The PEG is preferably branched and has an aldehyde serving as an activating group. The PEGylated asparaginase is useful in the preparation of anti-tumor drugs.

Abstract: The present application discloses a PEGylated asparaginase and use thereof. In this application, the polyethylene glycol (PEG) is coupled to the N-terminal amino of 1 or 2 subunits of L-asparaginase, and the molecular weight of the PEG is 30-40 KDa. The PEG is preferably branched and has an aldehyde group serving as an activating group. The PEGylated asparaginase is useful in the preparation of anti-tumor drugs.

Abstract: Methods for use of a multi-arm polyethylene glycol (PEG) modifier in modification of asparaginase. The described multi-arm PEG modifier enhances the subunit interaction of a multimeric protein to maintain the multimeric protein in a polymerized form, thereby improving the stability of the multimeric protein, maintaining the bioactivity of the multimeric protein, and reducing the probability of exposure of the antigen binding site after depolymerization of the subunits, so as to reduce the immunogenicity.

Abstract: The present invention relates to the field of electrotherapy and measuring by means of electric cur-rents for diagnostic purposes, and more particularly to an electrode arrangement for facilitating wound healing, a method for measuring wound healing and a wound dressing having an electrode arrangement. A wound dressing according is described which includes at least two impedance reference electrodes, a frame like counter-electrode and stimulation electrodes in a form of an array; and a bioadhesive affinity layer surrounding the stimulation electrodes; said wound dressing being suited for applying on top of the wound so that the stimulation electrode array is on the wound area, and that the at least two impedance reference electrodes and the frame like counter-electrode are suited for placing in contact with the healthy skin surrounding the wound area; which electrodes, are suited for applying LIDC type electrical stimulation current to the wound area and for bioimpedance measurement.

Abstract: A wound dressing according to the present invention comprises at least two impedance reference electrodes, a frame like counter-electrode and stimulation electrodes in a form of an array; and a bioadhesive affinity layer surrounding the stimulation electrodes; said wound dressing being suited for applying on top of the wound so that the stimulation electrode array is on the wound area, and that the at least two impedance reference electrodes and the frame like counter-electrode are suited for placing in contact with the healthy skin surrounding the wound area; which electrodes, are suited for applying LIDC type electrical stimulation current to the wound area and for bioimpedance measurement. The wound dressing according to the present invention provide a continuous, non-invasive and objective solution for monitoring chronic wound healing without disturbing the delicate healing process.

Abstract: The present invention relates to polyethylene glycol (PEG) modified protein drugs, and a PEGylated tissue kallikrein, a preparation method and use thereof are disclosed. The tissue kallikrein has a sequence as shown in SEQ ID No. 1 or SEQ ID No. 2, and the tissue kallikrein may be natural or recombinant. The PEG has a molecular weight of 20 to 40 kDa, and is conjugated to the N-terminal primary amino of the tissue kallikrein. In addition to the advantages of significantly extended half-life, significantly reduced immunogenicity and stable and uniform structure, the biological activity of the PEGylated KLK1 provided in the present invention is improved to a higher extent, which is more significant in the treatment of cerebral apoplexy and diabetic nephropathy in particular.

Abstract: The present application discloses a PEGylated asparaginase and use thereof. In this application, the polyethylene glycol (PEG) is coupled to the N-terminal amino of 1 or 2 subunits of L-asparaginase, and the molecular weight of the PEG is 30-40 KDa. The PEG is preferably branched and has an aldehyde group serving as an activating group. The PEGylated asparaginase is useful in the preparation of anti-tumor drugs.

Abstract: The present invention relates to polyethylene glycol (PEG) modified protein drugs, and a PEGylated tissue kallikrein, a preparation method and use thereof are disclosed. The tissue kallikrein has a sequence as shown in SEQ ID No. 1 or SEQ ID No. 2, and the tissue kallikrein may be natural or recombinant. The PEG has a molecular weight of 20 to 40 kDa, and is conjugated to the N-terminal primary amino of the tissue kallikrein. In addition to the advantages of significantly extended half-life, significantly reduced immunogenicity and stable and uniform structure, the biological activity of the PEGylated KLK1 provided in the present invention is improved to a higher extent, which is more significant in the treatment of cerebral apoplexy and diabetic nephropathy in particular.

Abstract: Methods for use of a multi-arm polyethylene glycol (PEG) modifier in modification of asparaginase. The described multi-arm PEG modifier enhances the subunit interaction of a multimeric protein to maintain the multimeric protein in a polymerized form, thereby improving the stability of the multimeric protein, maintaining the bioactivity of the multimeric protein, and reducing the probability of exposure of the antigen binding site after depolymerization of the subunits, so as to reduce the immunogenicity.

Abstract: The present invention relates to the field of electrotherapy and measuring by means of electric currents for diagnostic purposes, and more particularly to an electrode arrangement for facilitating wound healing, a method for measuring wound healing and a wound dressing having an electrode arrangement. A wound dressing according to the present invention comprises at least two impedance reference electrodes, a frame like counter-electrode and stimulation electrodes in a form of an array; and a bioadhesive affinity layer surrounding the stimulation electrodes; said wound dressing being suited for applying on top of the wound so that the stimulation electrode array is on the wound area, and that the at least two impedance reference electrodes and the frame like counter-electrode are suited for placing in contact with the healthy skin surrounding the wound area; which electrodes, are suited for applying LIDC type electrical stimulation current to the wound area and for bioimpedance measurement.

Abstract: The present invention relates to the field of electrotherapy and measuring by means of electric currents for diagnostic purposes, and more particularly to an electrode arrangement for facilitating wound healing, a method for measuring wound healing and a wound dressing having an electrode arrangement. A wound dressing according is described which includes at least two impedance reference electrodes, a frame like counter-electrode and stimulation electrodes in a form of an array; and a bioadhesive affinity layer surrounding the stimulation electrodes; said wound dressing being suited for applying on top of the wound so that the stimulation electrode array is on the wound area, and that the at least two impedance reference electrodes and the frame like counter-electrode are suited for placing in contact with the healthy skin surrounding the wound area; which electrodes, are suited for applying LIDC type electrical stimulation current to the wound area and for bioimpedance measurement.