Patents by Inventor Chunlin Xu
Chunlin Xu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 12369767Abstract: The present disclosure provides a cleaning robot docking station and a cleaning system with the cleaning robot docking station. The cleaning robot docking station includes an evaporation equipment, configured to evaporate liquid inside the evaporation equipment and expel a first gas. The cleaning robot docking station further includes a condensation equipment, configured to receive the first gas from the evaporation equipment, condense at least a part of the water vapor in the first gas, and expel a second gas. The first gas is pre-cooled before entering the condensation equipment.Type: GrantFiled: February 25, 2025Date of Patent: July 29, 2025Assignee: TP-Link Systems Inc.Inventors: Ning Cheng, Yuhong Hu, Feixiang Mei, Chunlin Xu
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Publication number: 20250059311Abstract: According to an example aspect of the present invention, here is provided a polysaccharide ether grafted with poly(alkyl acrylate), a latex comprising a polysaccharide ether grafted with poly(alkyl acrylate), and a method of manufacturing a biobased emulsion comprising the steps of providing an allylated polysaccharide ether derivative and grafting the allylated polysaccharide ether derivative with a poly(alkyl acrylate) by emulsion polymerization, a biobased film formed by the said latex or said method and the use of the latex and emulsion.Type: ApplicationFiled: December 29, 2022Publication date: February 20, 2025Inventors: Qiwen Yong, Chunlin Xu, Martti Toivakka
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Publication number: 20230014619Abstract: The invention relates to a method for producing cationized cellulose. The method comprises at least preparing a slurry of a cellulosic starting material in an alkaline liquid medium which comprises an organic liquid and performing mercerization of the slurry. The concentration of the cellulosic starting material in the slurry is at least 20 weight-%, calculated as dry from total weight of the liquid medium and the cellulosic starting material. A cationizing agent is added to the slurry after the mercerization step at a cationization temperature, which is less than the boiling point of the alkaline liquid medium, and the cellulose in the slurry is allowed to react with the cationizing agent, preferably under inert atmosphere and a cationized cellulose product is obtained.Type: ApplicationFiled: December 4, 2020Publication date: January 19, 2023Inventors: Veli-Matti VUORENPALO, Jonni AHLGREN, Jaakko HILTUNEN, Anna-Maija PERANDER, Chunlin XU, Sanna LEHTO, Eija AHONEN, Tarja IKÄVALKO
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Patent number: 11103565Abstract: The present application discloses a PEGylated asparaginase and use thereof. In this application, the polyethylene glycol (PEG) is coupled to the N-terminal amino of 1 or 2 subunits of L-asparaginase, and the molecular weight of the PEG is 30-40 KDa. The PEG is preferably branched and has an aldehyde serving as an activating group. The PEGylated asparaginase is useful in the preparation of anti-tumor drugs.Type: GrantFiled: January 17, 2020Date of Patent: August 31, 2021Assignees: ZONHON BIOPHARMA INSTITUTE INC., GENSUN INSTITUTE OF BIOMEDICINE CO., LTD.Inventors: Bruce Yong Ma, Jun Wang, He Wang, Chunlin Xu, Yifei Chen, Yaofang Wang
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Publication number: 20200222515Abstract: The present application discloses a PEGylated asparaginase and use thereof. In this application, the polyethylene glycol (PEG) is coupled to the N-terminal amino of 1 or 2 subunits of L-asparaginase, and the molecular weight of the PEG is 30-40 KDa. The PEG is preferably branched and has an aldehyde serving as an activating group. The PEGylated asparaginase is useful in the preparation of anti-tumor drugs.Type: ApplicationFiled: January 17, 2020Publication date: July 16, 2020Applicants: ZONHON BIOPHARMA INSTITUTE INC., GENSUN INSTITUTE OF BIOMEDICINE CO., LTD.Inventors: Bruce Yong MA, Jun WANG, He WANG, Chunlin XU, Yifei CHEN, Yaofang WANG
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Patent number: 10537620Abstract: The present application discloses a PEGylated asparaginase and use thereof. In this application, the polyethylene glycol (PEG) is coupled to the N-terminal amino of 1 or 2 subunits of L-asparaginase, and the molecular weight of the PEG is 30-40 KDa. The PEG is preferably branched and has an aldehyde group serving as an activating group. The PEGylated asparaginase is useful in the preparation of anti-tumor drugs.Type: GrantFiled: February 3, 2015Date of Patent: January 21, 2020Assignees: ZONHON BIOPHARMA INSTITUTE INC., GENSUN INSTITUTE OF BIOMEDICINE CO., LTD.Inventors: Bruce Yong Ma, Jun Wang, He Wang, Chunlin Xu, Yifei Chen, Yaofang Wang
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Patent number: 10406235Abstract: Methods for use of a multi-arm polyethylene glycol (PEG) modifier in modification of asparaginase. The described multi-arm PEG modifier enhances the subunit interaction of a multimeric protein to maintain the multimeric protein in a polymerized form, thereby improving the stability of the multimeric protein, maintaining the bioactivity of the multimeric protein, and reducing the probability of exposure of the antigen binding site after depolymerization of the subunits, so as to reduce the immunogenicity.Type: GrantFiled: July 28, 2014Date of Patent: September 10, 2019Assignees: ZONHON BIOPHARMA INSTITUTE INC., GENSUN INSTITUTE OF BIOMEDICINE CO., LTD.Inventors: Bruce Yong Ma, Jun Wang, Dinglong Wu, Chunlin Xu, Yaofang Wang
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Patent number: 10206604Abstract: The present invention relates to the field of electrotherapy and measuring by means of electric cur-rents for diagnostic purposes, and more particularly to an electrode arrangement for facilitating wound healing, a method for measuring wound healing and a wound dressing having an electrode arrangement. A wound dressing according is described which includes at least two impedance reference electrodes, a frame like counter-electrode and stimulation electrodes in a form of an array; and a bioadhesive affinity layer surrounding the stimulation electrodes; said wound dressing being suited for applying on top of the wound so that the stimulation electrode array is on the wound area, and that the at least two impedance reference electrodes and the frame like counter-electrode are suited for placing in contact with the healthy skin surrounding the wound area; which electrodes, are suited for applying LIDC type electrical stimulation current to the wound area and for bioimpedance measurement.Type: GrantFiled: December 5, 2015Date of Patent: February 19, 2019Assignee: CutoSense OyInventors: Mikael Bergelin, Jan-Erik Eriksson, Max Johansson, Chunlin Xu, Ann-Sofie Leppänen, Stefan Willför, Simo Köppä, Atte Kekonen, Heimo O. Ylänen, Jari Viik, Jari Hytti
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Patent number: 10166387Abstract: A wound dressing according to the present invention comprises at least two impedance reference electrodes, a frame like counter-electrode and stimulation electrodes in a form of an array; and a bioadhesive affinity layer surrounding the stimulation electrodes; said wound dressing being suited for applying on top of the wound so that the stimulation electrode array is on the wound area, and that the at least two impedance reference electrodes and the frame like counter-electrode are suited for placing in contact with the healthy skin surrounding the wound area; which electrodes, are suited for applying LIDC type electrical stimulation current to the wound area and for bioimpedance measurement. The wound dressing according to the present invention provide a continuous, non-invasive and objective solution for monitoring chronic wound healing without disturbing the delicate healing process.Type: GrantFiled: May 21, 2014Date of Patent: January 1, 2019Assignee: CutoSense OyInventors: Mikael Bergelin, Jan-Erik Eriksson, Max Johansson, Chunlin Xu, Ann-Sofie Leppänen, Stefan Willför, Simo Köppä, Atte Kekonen, Heimo O. Ylänen, Jari Viik, Jari Hyttinen
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Patent number: 10052368Abstract: The present invention relates to polyethylene glycol (PEG) modified protein drugs, and a PEGylated tissue kallikrein, a preparation method and use thereof are disclosed. The tissue kallikrein has a sequence as shown in SEQ ID No. 1 or SEQ ID No. 2, and the tissue kallikrein may be natural or recombinant. The PEG has a molecular weight of 20 to 40 kDa, and is conjugated to the N-terminal primary amino of the tissue kallikrein. In addition to the advantages of significantly extended half-life, significantly reduced immunogenicity and stable and uniform structure, the biological activity of the PEGylated KLK1 provided in the present invention is improved to a higher extent, which is more significant in the treatment of cerebral apoplexy and diabetic nephropathy in particular.Type: GrantFiled: January 9, 2014Date of Patent: August 21, 2018Assignees: ZONHON BIOPHARMA INSTITUTE INC., GENSUN INSTITUTE OF BIOMEDICINE CO., LTD.Inventors: Bruce Yong Ma, Jun Wang, Jing Qiu, Dinglong Wu, Chunlin Xu, Chen Chen, Yaofang Wang
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Publication number: 20180161408Abstract: The present application discloses a PEGylated asparaginase and use thereof. In this application, the polyethylene glycol (PEG) is coupled to the N-terminal amino of 1 or 2 subunits of L-asparaginase, and the molecular weight of the PEG is 30-40 KDa. The PEG is preferably branched and has an aldehyde group serving as an activating group. The PEGylated asparaginase is useful in the preparation of anti-tumor drugs.Type: ApplicationFiled: February 3, 2015Publication date: June 14, 2018Applicants: ZONHON BIOPHARMA INSTITUTE INC., GENSUN INSTITUTE OF BIOMEDICINE CO., LTD.Inventors: Bruce Yong MA, Jun WANG, He WANG, Chunlin XU, Yifei CHEN, Yaofang WANG
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Publication number: 20170049864Abstract: The present invention relates to polyethylene glycol (PEG) modified protein drugs, and a PEGylated tissue kallikrein, a preparation method and use thereof are disclosed. The tissue kallikrein has a sequence as shown in SEQ ID No. 1 or SEQ ID No. 2, and the tissue kallikrein may be natural or recombinant. The PEG has a molecular weight of 20 to 40 kDa, and is conjugated to the N-terminal primary amino of the tissue kallikrein. In addition to the advantages of significantly extended half-life, significantly reduced immunogenicity and stable and uniform structure, the biological activity of the PEGylated KLK1 provided in the present invention is improved to a higher extent, which is more significant in the treatment of cerebral apoplexy and diabetic nephropathy in particular.Type: ApplicationFiled: January 9, 2014Publication date: February 23, 2017Applicants: ZONHON BIOPHARMA INSTITUTE INC., GENSUN INSTITUTE OF BIOMEDICINE CO.,LTD.Inventors: Bruce Yong MA, Jun WANG, Jing QIU, Dinglong WU, Chunlin XU, Chen CHEN, Yaofang WANG
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Publication number: 20170043028Abstract: Methods for use of a multi-arm polyethylene glycol (PEG) modifier in modification of asparaginase. The described multi-arm PEG modifier enhances the subunit interaction of a multimeric protein to maintain the multimeric protein in a polymerized form, thereby improving the stability of the multimeric protein, maintaining the bioactivity of the multimeric protein, and reducing the probability of exposure of the antigen binding site after depolymerization of the subunits, so as to reduce the immunogenicity.Type: ApplicationFiled: July 28, 2014Publication date: February 16, 2017Applicants: ZONHON BIOPHARMA INSTITUTE INC., GENSUN INSTITUTE OF BIOMEDICINE CO.,LTD.Inventors: Bruce Yong MA, Jun WANG, Dinglong WU, Chunlin XU, Yaofang WANG
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Publication number: 20160101282Abstract: The present invention relates to the field of electrotherapy and measuring by means of electric currents for diagnostic purposes, and more particularly to an electrode arrangement for facilitating wound healing, a method for measuring wound healing and a wound dressing having an electrode arrangement. A wound dressing according to the present invention comprises at least two impedance reference electrodes, a frame like counter-electrode and stimulation electrodes in a form of an array; and a bioadhesive affinity layer surrounding the stimulation electrodes; said wound dressing being suited for applying on top of the wound so that the stimulation electrode array is on the wound area, and that the at least two impedance reference electrodes and the frame like counter-electrode are suited for placing in contact with the healthy skin surrounding the wound area; which electrodes, are suited for applying LIDC type electrical stimulation current to the wound area and for bioimpedance measurement.Type: ApplicationFiled: May 21, 2014Publication date: April 14, 2016Inventors: Mikael Bergelin, Jan-Erik Eriksson, Max Johansson, Chunlin Xu, Ann-Sofie Leppänen, Stefan Willför, Simo Köppä, Atte Kekonen, Heimo O. Ylänen, Jari Viik, Jari Hyttinen
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Publication number: 20160081580Abstract: The present invention relates to the field of electrotherapy and measuring by means of electric currents for diagnostic purposes, and more particularly to an electrode arrangement for facilitating wound healing, a method for measuring wound healing and a wound dressing having an electrode arrangement. A wound dressing according is described which includes at least two impedance reference electrodes, a frame like counter-electrode and stimulation electrodes in a form of an array; and a bioadhesive affinity layer surrounding the stimulation electrodes; said wound dressing being suited for applying on top of the wound so that the stimulation electrode array is on the wound area, and that the at least two impedance reference electrodes and the frame like counter-electrode are suited for placing in contact with the healthy skin surrounding the wound area; which electrodes, are suited for applying LIDC type electrical stimulation current to the wound area and for bioimpedance measurement.Type: ApplicationFiled: December 5, 2015Publication date: March 24, 2016Inventors: Mikael Bergelin, Jan-Erik Eriksson, Max Johansson, Chunlin Xu, Ann-Sofie Leppänen, Stefan Willför, Simo Köppä, Atte Kekonen, Heimo O. Ylänen, Jari Viik, Jari Hytti