Patents by Inventor Chunmei HOU

Chunmei HOU has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Human Tim-3 fusion protein capable of blocking Tim-3 signaling pathway
    Patent number: 9644020
    Abstract: The present invention provides a human Tim-3-Ig fusion protein which can block Tim-3 signal pathway, and said Ig fusion protein comprises Tim-3 protein, human Ig fragment, and the linking sequence therebetween. In the present invention, a human Tim-3-Ig gene is obtained by an artificial synthesis process; an expression vector containing the Tim-3-Ig gene is constructed; and the prepared Ig fusion protein is tested in an expression verification experiment, a binding activity experiment, a blocking activity experiment in different cell lines, and in vivo experiments in mice. The human Tim-3-Ig fusion protein prepared in the present invention can be used to treat immunological diseases caused by high expression of Tim-3.
    Type: Grant
    Filed: January 20, 2015
    Date of Patent: May 9, 2017
    Assignee: Institute of Basic Medical Science, the Academy of Military Medical Science of the Chinese PLA
    Inventors: Gencheng Han, Guojiang Chen, Xingwei Jiang, Renxi Wang, He Xiao, Chunmei Hou, Jiahui Yu, Zhi Zhao, Jiannan Feng, Yan Li, Beifen Shen
  • HUMAN TIM-3 FUSION PROTEIN CAPABLE OF BLOCKING TIM-3 SIGNALING PATHWAY
    Publication number: 20170029485
    Abstract: The present invention provides a human Tim-3-Ig fusion protein which can block Tim-3 signal pathway, and said Ig fusion protein comprises Tim-3 protein, human Ig fragment, and the linking sequence therebetween. In the present invention, a human Tim-3-Ig gene is obtained by an artificial synthesis process; an expression vector containing the Tim-3-Ig gene is constructed; and the prepared Ig fusion protein is tested in an expression verification experiment, a binding activity experiment, a blocking activity experiment in different cell lines, and in vivo experiments in mice. The human Tim-3-Ig fusion protein prepared in the present invention can be used to treat immunological diseases caused by high expression of Tim-3.
    Type: Application
    Filed: January 20, 2015
    Publication date: February 2, 2017
    Inventors: Gencheng HAN, Guojiang CHEN, Xingwei JIANG, Renxi WANG, He XIAO, Chunmei HOU, Jiahui YU, Zhi ZHAO, Jiannan FENG, Yan LI, Beifen SHEN