Patents by Inventor Chun-Mei Hu

Chun-Mei Hu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ANTAGONIST OF INTERLEUKIN-17B RECEPTOR (IL-17RB) AND USE THEREOF
    Publication number: 20240124528
    Abstract: The present invention relates to an antagonist of interleukin-17B receptor (IL-17RB) which features interruption of the interaction of IL-17RB and MLK4. The present invention also relates to use of such antagonist for treatment of diseases or disorders associated with IL-17RB activation. Further disclosed is a phosphorylated IL-17RB as a biomarker for predicting prognosis and/or monitoring progression of cancer.
    Type: Application
    Filed: December 14, 2021
    Publication date: April 18, 2024
    Applicant: Academia Sinica
    Inventors: Wen-Hwa LEE, Heng-Hsiung WU, Chun-Mei HU, Chun-Kai HUANG
  • Small molecule modifiers of the Hec1-Nek2 interaction in G2/M
    Patent number: 9670197
    Abstract: Certain embodiments of the present invention provide selected compounds having a molecular structure according to Formula 1: In Formula 1, Z is —CO—, —SO—, or —SO2—; Ar is phenyl, heteroaryl, or heterocycloalkyl; Het is heteroaryl; R is R?, X, or NR1R2; R? is R3, or OR3; R? is R4, or OR4; R1 and R2 are each independently H, alkyl, or acyl; R3 is H, heteroaryl, or alkyl; R4 is H, heteroaryl, or CnH2n+1 (n>2); and X is F, Br, I, CN, or NO2. In some embodiments, compounds having a molecular structure according to Formula 1 have the property of inhibiting a growth of a cell line selected from HeLa and MB468 with a sub-micromolar IC50.
    Type: Grant
    Filed: July 8, 2016
    Date of Patent: June 6, 2017
    Assignee: The Regents of the University of California
    Inventors: Wen-Hwa Lee, Jiewen Zhu, Chun-Mei Hu
  • SMALL MOLECULE MODIFIERS OF THE HEC1-NEK2 INTERACTION IN G2/M
    Publication number: 20160318918
    Abstract: Certain embodiments of the present invention provide selected compounds having a molecular structure according to Formula 1: In Formula 1, Z is —CO—, —SO—, or —SO2—; Ar is phenyl, heteroaryl, or heterocycloalkyl; Het is heteroaryl; R is R?, X, or NR1R2; R? is R3, or OR3; R? is R4, or OR4; R1 and R2 are each independently H, alkyl, or acyl; R3 is H, heteroaryl, or alkyl; R4 is H, heteroaryl, or CnH2n+1 (n>2); and X is F, Br, I, CN, or NO2. In some embodiments, compounds having a molecular structure according to Formula 1 have the property of inhibiting a growth of a cell line selected from HeLa and MB468 with a sub-micromolar IC50.
    Type: Application
    Filed: July 8, 2016
    Publication date: November 3, 2016
    Applicant: The Regents of the University of California
    Inventors: Wen-Hwa Lee, Jiewen Zhu, Chun-Mei Hu
  • Small molecule modifiers of the HEC1-NEK2 interaction in G2/M
    Patent number: 9422275
    Abstract: Certain embodiments of the present invention provide selected compounds having a molecular structure according to Formula 1: In Formula 1, Z is —CO—, —SO—, or —SO2—; Ar is phenyl, heteroaryl, or heterocycloalkyl; Het is heteroaryl; R is R?, X, or NR1R2; R? is R3, or OR3; R? is R4, or OR4; R1 and R2 are each independently H, alkyl, or acyl; R3 is H, heteroaryl, or alkyl; R4 is H, heteroaryl, or CnH2n+1 (n>2); and X is F, Br, I, CN, or NO2. In some embodiments, compounds having a molecular structure according to Formula 1 have the property of inhibiting a growth of a cell line selected from HeLa and MB468 with a sub-micromolar IC50.
    Type: Grant
    Filed: July 19, 2014
    Date of Patent: August 23, 2016
    Assignee: The Regents of the University of California
    Inventors: Wen-Hwa Lee, Jiewen Zhu, Chun-Mei Hu
  • Targeting human thymidylate kinase induces DNA repair toxicity in malignant tumor cells
    Patent number: 9278982
    Abstract: The present invention relates to novel TMPK inhibitor compositions and their methods of use. In particular, it relates to novel TMPK inhibitor compositions and therapeutics that lead to dUTP-mediated DNA repair in tumor cells and acts as a novel chemosensitizer, which are useful in methods for treating or preventing cancers.
    Type: Grant
    Filed: November 29, 2011
    Date of Patent: March 8, 2016
    Assignees: NATIONAL YANG-MING UNIVERSITY, NATIONAL TAIWAN UNIVERSITY
    Inventors: Zee Fen Chang, Jim-Min Fang, Chun-Mei Hu, Ming-Tyng Yeh
  • SMALL MOLECULE MODIFIERS OF THE HEC1-NEK2 INTERACTION IN G2/M
    Publication number: 20150105391
    Abstract: Certain embodiments of the present invention provide selected compounds having a molecular structure according to Formula 1: In Formula 1, Z is —CO—, —SO—, or —SO2—; Ar is phenyl, heteroaryl, or heterocycloalkyl; Het is heteroaryl; R is R?, X, or NR1R2; R? is R3, or OR3; R? is R4, or OR4; R1 and R2 are each independently H, alkyl, or acyl; R3 is H, heteroaryl, or alkyl; R4 is H, heteroaryl, or CnH2n+1 (n>2); and X is F, Br, I, CN, or NO2. In some embodiments, compounds having a molecular structure according to Formula 1 have the property of inhibiting a growth of a cell line selected from HeLa and MB468 with a sub-micromolar IC50.
    Type: Application
    Filed: July 19, 2014
    Publication date: April 16, 2015
    Inventors: Wen-Hwa Lee, Jiewen Zhu, Chun-Mei Hu
  • Targeting Human Thymidylate Kinase Induces DNA Repair Toxicity in Malignant Tumor Cells
    Publication number: 20130252953
    Abstract: The present invention relates to novel TMPK inhibitor compositions and their methods of use. In particular, it relates to novel TMPK inhibitor compositions and therapeutics that lead to dUTP-mediated DNA repair in tumor cells and acts as a novel chemosensitizer, which are useful in methods for treating or preventing cancers.
    Type: Application
    Filed: November 29, 2011
    Publication date: September 26, 2013
    Inventors: Zee-Fen Chang, Jim-Min Fang, Chun-Mei Hu, Ming-Tyng Yeh