Abstract: A method for measuring specific migration amount of an antioxidants in a polyethylene terephthalate (PET)/polyethylene (PE) compound food contact material is disclosed. More specifically, a method for simultaneously measuring the specific migration amount of 16 antioxidants in PET/PE compound food contact material while establishing a high performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) is disclosed. The 16 target compounds determined by the method have a good linear relationship in the corresponding range, the correlation coefficient is greater than 0.995, the quantitative limit of the aqueous food simulant is 0.1-1.3 ng/kg, and the quantitative limit of the olive oil food simulant is 0.3-3.0 ?g/kg. The average recovery is 81.0-112% and the relative standard deviation is 0.4-9.1% at the spiked level of 2.0-20 ?g/kg.