Patents by Inventor Chunxia LIU

Chunxia LIU has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Long-acting oxyntomodulin hybrid peptide, preparation method therefor, and application thereof
    Patent number: 11970523
    Abstract: The present invention discloses a polypeptide and application thereof. By modifying oxyntomodulin (OXM), hybridizing OXM with a peptide sequence of Exenatide, including enabling the polypeptide to be resistant to DPP-4 enzyme degradation through amino acid modification, and conjugating fatty acid chains at the same time, an OXM hybrid peptide having longer pharmacologic action time and better weight losing effects is obtained. Synthesis of a target polypeptide is fast realized by an orthogonal protection strategy solid-phase synthesis method, and a crude product is purified and freeze-dried to obtain the OXM hybrid peptide.
    Type: Grant
    Filed: May 6, 2019
    Date of Patent: April 30, 2024
    Assignee: CHINA PHARMACEUTICAL UNIVERSITY
    Inventors: Hai Qian, Wenlong Huang, Xingguang Cai, Chengye Li, Chunxia Liu, Yuxuan Dai
  • Phenoxyacetic acid derivatives, preparation method thereof and use thereof as medicament
    Patent number: 11905230
    Abstract: The present invention relates to a novel phenoxyacetic acid derivative represented by the general formula (I), preparation method thereof and use of a pharmaceutical composition containing the derivative in preparing a medicament for treating diabetes and metabolic syndrome. The phenoxyacetic acid derivatives have excellent in vivo hypoglycemic activity, which can be used for preventing or treating diabetes.
    Type: Grant
    Filed: May 24, 2018
    Date of Patent: February 20, 2024
    Assignee: CHINA PHARMACEUTICAL UNIVERSITY
    Inventors: Hai Qian, Wenlong Huang, Chunxia Liu, Jianyong Yang
  • LONG-ACTING OXYNTOMODULIN HYBRID PEPTIDE, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF
    Publication number: 20220177537
    Abstract: The present invention discloses a polypeptide and application thereof. By modifying oxyntomodulin (OXM), hybridizing OXM with a peptide sequence of Exenatide, including enabling the polypeptide to be resistant to DPP-4 enzyme degradation through amino acid modification, and conjugating fatty acid chains at the same time, an OXM hybrid peptide having longer pharmacologic action time and better weight losing effects is obtained. Synthesis of a target polypeptide is fast realized by an orthogonal protection strategy solid-phase synthesis method, and a crude product is purified and freeze-dried to obtain the OXM hybrid peptide.
    Type: Application
    Filed: May 6, 2019
    Publication date: June 9, 2022
    Inventors: Hai QIAN, Wenlong HUANG, Xingguang CAI, Chengye LI, Chunxia LIU, Yuxuan DAI
  • NOVEL WHEAT CENH3 ALLELES
    Publication number: 20210378192
    Abstract: The present invention relates to wheat plants comprising a mutation causing an alteration of the amino acid sequence in centromere histone H3 (CENH3), which have the biological activity of a haploid inducer. Further, the present invention provides methods of generating the wheat plants of the present invention and haploid and doubled haploid wheat plants obtainable by crossing the wheat plants of the present invention with wildtype wheat plants.
    Type: Application
    Filed: October 10, 2019
    Publication date: December 9, 2021
    Applicant: Syngenta Crop Protection AG
    Inventors: Jain LV, Kun YU, Juan WEI, Chunxia Liu, Hongju Zhou, Timothy Joseph Kelliher
  • NOVEL PHENOXUACETIC ACID DERIVATIVE, PREPARATION METHOD THEREFOR AND USES OF DERIVATIVE AS DRUG
    Publication number: 20210122704
    Abstract: The present invention relates to a novel phenoxyacetic acid derivative represented by the general formula (I), preparation method thereof and use of a pharmaceutical composition containing the derivative in preparing a medicament for treating diabetes and metabolic syndrome. The phenoxyacetic acid derivatives have excellent in vivo hypoglycemic activity, which can be used for preventing or treating diabetes.
    Type: Application
    Filed: May 24, 2018
    Publication date: April 29, 2021
    Inventors: Hai QIAN, Wenlong HUANG, Chunxia LIU, Jianyong YANG