Patents by Inventor Chun-yang Zhang

Chun-yang Zhang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Single quantum-dot based aptameric nanosensors
    Patent number: 8642260
    Abstract: A signal-off-quantum-dot-based sensor for detecting the presence of a target molecule comprising: an aptamer probe having a nucleotide sequence which specifically interacts with the target molecule by sequence-dependent interaction, wherein the aptamer probe is sandwiched between (a) an oligonucleotide which is immobilized on the surface of a quantum dot (QD), and (b) a fluorophore-labeled oligonucleotide, wherein when the sensor is excited by an energy source: (i) in the absence of specific interaction between the target molecule and the aptamer probe, a baseline signal is emitted, and (ii) in the presence of specific interaction between the target molecule and the aptamer probe, a detection signal is emitted, wherein the baseline signal is greater than the detection signal, whereby the presence of the target molecule is detected.
    Type: Grant
    Filed: October 21, 2009
    Date of Patent: February 4, 2014
    Assignee: The Research Foundation of the City University of New York
    Inventors: Chun-yang Zhang, Lawrence W. Johnson
  • SINGLE QUANTUM-DOT BASED APTAMERIC NANOSENSORS
    Publication number: 20110287557
    Abstract: A signal-off-quantum-dot-based sensor for detecting the presence of a target molecule comprising: an aptamer probe having a nucleotide sequence which specifically interacts with the target molecule by sequence-dependent interaction, wherein the aptamer probe is sandwiched between (a) an oligonucleotide which is immobilized on the surface of a quantum dot (QD), and (b) a fluorophore-labeled oligonucleotide, wherein when the sensor is excited by an energy source: (i) in the absence of specific interaction between the target molecule and the aptamer probe, a baseline signal is emitted, and (ii) in the presence of specific interaction between the target molecule and the aptamer probe, a detection signal is emitted, wherein the baseline signal is greater than the detection signal, whereby the presence of the target molecule is detected.
    Type: Application
    Filed: October 21, 2009
    Publication date: November 24, 2011
    Applicant: Research Foundation of the City University of New York
    Inventors: Chun-yang Zhang, Lawrence W. Johnson