Abstract: The present disclosure provides a method for artificial rearing of porcupine pufferfish fries in indoor cement ponds. The method includes the following steps: nursery pond preparation, ponding of newly hatched prelarvae, feeding strategies at fry rearing stages, water quality management during fry rearing, separate ponding of fries, and emergence of fries. Compared with the prior art, the method realizes large-scale production of artificial rearing of porcupine pufferfish fries through a strict control of the water quality and environmental conditions of a nursery pond, along with scientific and reasonable feeding and operation management based on biological characteristics and nutrient requirements of the porcupine pufferfish at different fry breeding stages.