Abstract: A method for detecting a lesion in an anatomical region of interest is presented. The method includes identifying one or more candidate mass regions in each of a plurality of 3D ultrasound images acquired at different view angles from the anatomical region of interest. Single-view features corresponding to each candidate mass region are identified. For a candidate mass region, a similarity metric between the single-view features corresponding to the candidate mass region and the single-view features corresponding to the other candidate mass regions is determined. The candidate mass region is classified based at least on the similarity metric. A system for imaging and a non-transitory computer readable media for detection of the lesion are also presented.