Abstract: A textile actuator worn by a user comprises a textile envelope that defines a chamber made fluid-impermeable by a fluid-impermeable bladder contained in the textile envelope and/or a fluid-impermeable structure incorporated into the textile envelope. The textile envelope has a pre-determined geometry that produces an equilibrium state at a non-180°-angle displacement and that stops further displacement upon pressurization of the chamber and prevents over-extension of the joint. A fluid is delivered into or out of the chamber to displace the textile envelope primarily by transitioning from an uninflated state to the pre-determined geometry due to displacement of the textile envelope rather than via stretching or contraction of the textile envelope. When actuated, the textile actuator (a) displaces a body segment of the user and/or (b) supports and holds the body segment of the user in place.

Abstract: A textile actuator and harness system can include a harness configured to be worn with a portion extending across a wearer's joint. The harness comprises a substantially inextensible section and at least two mounting locations spaced for positioning across the joint, with at least one located along the substantially inextensible section of the harness. A textile envelope defines a chamber and is made fluid-impermeable by (a) a fluid-impermeable bladder contained in the textile envelope and/or (b) a fluid-impermeable structure incorporated into the textile envelope. The textile envelope is secured to the harness at each mounting location, and the textile envelope has a pre-determined geometry configured to produce assistance to the joint due to inflation of the textile envelope during a relative increase in pressure inside the chamber.

Abstract: Provided herein are compounds of Formula (I) and pharmaceutically acceptable salts thereof, useful as RIPK1 inhibitors, and pharmaceutical compositions comprising same. Further provided are methods of use and preparation. Also provided are methods of treating Ulcerative Colitis using a compound of Formula (I).

Abstract: A textile actuator worn by a user comprises a textile envelope that defines a chamber made fluid-impermeable by a fluid-impermeable bladder contained in the textile envelope and/or a fluid-impermeable structure incorporated into the textile envelope. The textile envelope has a pre-determined geometry that produces an equilibrium state at a non-180-angle displacement and that stops further displacement upon pressurization of the chamber and prevents over-extension the joint. A fluid is delivered into or out of the chamber to displace the textile envelope primarily by transitioning from an uninflated state to the pre-determined geometry due to displacement of the textile envelope rather than via stretching or contraction of the textile envelope. When actuated, the textile actuator (a) displaces a body segment of the user and/or (b) supports and holds the body segment of the user in place.

Abstract: A laser ablation system, and method, facilitates the execution of user-defined scans (i.e., in which a laser beam is scanned across a sample along a beam trajectory to ablate or dissociate a portion of the sample) and enables the user define additional scans while a scan is being executed.

Abstract: Methods, devices, and system for determining and generating environmental impact and sustainability score (EISS) labels and certificates for a food item. A computing device may be configured to receive a food item description, determine one or more food ingredients based on the received food item description, determine a food ingredient EISS value for each of the determined food ingredients based on information retrieved from a food ingredient repository, and determine a food item EISS value based on the determined food ingredient EISS values. The computing device may generate an EISS label based on the determined food item EISS value, such as by generating an encrypted label information structure and/or an EISS digital certificate (EISSDC).

Abstract: Provided herein are compounds of Formula (I) and pharmaceutically acceptable salts thereof, useful as RIPK1 inhibitors, and pharmaceutical compositions comprising same. Further provided are methods of use and preparation. Also provided are methods of treating Ulcerative Colitis using a compound of Formula (I).

Abstract: Systems and methods related to the operation of wearable robotic systems are disclosed. In one embodiment, a wearable robotic system may be calibrated by correlating a measured joint angle and an actuation pressure. In another embodiment, a wearable robotic system may be operated to provide gravity compensation by operating one or more actuators of the system based on an estimated current pose of a first body portion associated with a joint and calibration parameters of the system to support at least a portion of a weight of the first body portion.

Abstract: Provided herein are compounds of Formula (I) and pharmaceutically acceptable salts thereof, useful as RIPK1 inhibitors, and pharmaceutical compositions comprising same. Further provided are methods of use and preparation. Also provided are methods of treating Ulcerative Colitis using a compound of Formula (I).

Abstract: An implant 801 for closing an opening in tissue such as a fistula or a sinus comprises a coil having a substantially uniform outer diameter. The coil forms an internal passage having a diameter that tapers from a distal end to a proximal end. The implant 801 may be delivered using a non-tapered driver coil 820.

Abstract: The present disclosure relates to compositions comprising a range of ingredients suitable for use in adjusting and/or treating a companion animal such as a canid (e.g. a dog) or a feline (e.g. a cat) and their microbiomes, monitoring tools, and diagnostic methods for determining the health of a companion animal and their microbiome.

Abstract: An implant 801 for closing an opening in tissue such as a fistula or a sinus comprises a coil having a substantially uniform outer diameter. The coil forms an internal passage having a diameter that tapers from a distal end to a proximal end. The implant 801 may be delivered using a non-tapered driver coil 820.

Abstract: An aircraft (1) including a fixed wing (7) and a wing tip device (9) moveably mounted thereon. The wing tip device (9) is movable from a load-alleviating configuration to a flight configuration. The wing tip device includes an airflow channel (88) extending between respective apertures (83, 84) on the upper surface and lower surface of the wing tip device. The channel (88) is configurable between an open state in which air can flow through the channel and a closed state in which the airflow through the channel (88), via the apertures (83, 84), is blocked. The channel (88) is configured such that when the wing tip device (9) is in the load-alleviating configuration and the channel (88) is in the open state, the aerodynamic loading on the wing tip device in flight urges the wing tip device towards the flight configuration.

Abstract: Methods for assessing a feline's microbiome health are provided. The methods include, inter alia, determining the health of a feline's microbiome comprising quantitation four or more bacterial species and determining the relative abundance of the four or more bacterial species by comparing the abundance with a control data set, wherein an increase or decrease in the abundance can be indicative of an unhealthy microbiome.

Abstract: An actuator assembly for moving an aircraft wing tip device is disclosed. The wing tip device is rotatable about a hinge axis relative to a fixed wing of the aircraft. The hinge axis is orientated non-parallel to a line-of-flight direction of the aircraft. The actuator assembly includes a primary shaft having an axis of rotation orientated substantially parallel to the line-of-flight direction, a motor to cause rotation of the primary shaft, and a secondary shaft orientated substantially parallel to the hinge axis. The secondary shaft is couplable to the primary shaft and is arranged to rotate the wing tip device in response to the rotation of the primary shaft.

Abstract: Methods for assessing the microbiome of a feline are provided. The methods include, inter alia, detecting one or more bacterial species in a sample obtained from the feline, comparing the one or more bacterial species to a control data set, and determining the microbiome age.

Abstract: A textile actuator and harness system can include a harness configured to be worn with a portion extending across a wearer's joint. The harness comprises a substantially inextensible section and at least two mounting locations spaced for positioning across the joint, with at least one located along the substantially inextensible section of the harness. A textile envelope defines a chamber and is made fluid-impermeable by (a) a fluid-impermeable bladder contained in the textile envelope and/or (b) a fluid-impermeable structure incorporated into the textile envelope. The textile envelope is secured to the harness at each mounting location, and the textile envelope has a pre-determined geometry configured to produce assistance to the joint due to inflation of the textile envelope during a relative increase in pressure inside the chamber.

Abstract: The invention relates to a silyl-containing polymer that is used, together with a tackifying resin to form an adhesive composition capable of storing and delivering drugs to the skin of a user. Typically the composition is formed into a patch which shows excellent adhesion to the skin even when drugs and other additives are dissolved into the composition.