Abstract: Systems and methods for optimized processing of global regulatory submissions to health authorities. A content management system provides an end-to-end solution for submitting regulatory documents, from authoring through uploading to a health authority gateway. The content management system creates, manages and consigns submission content plans for a regulatory event requiring regulatory approval based on a global content plan. The content plans may be generated based on content plan templates which may take into account submission information and can be dispatched separately by sections, components, or groupings. The global and local submission plans are collated to generate a comparison. A comparison viewer user interface displays the side by side hierarchical comparison of global with submission content plan where each row is a content plan item with differences highlighted.