Abstract: The present disclosure provides systems and methods that include or otherwise leverage a machine-learned neural synthesizer model. Unlike a traditional synthesizer which generates audio from hand-designed components like oscillators and wavetables, the neural synthesizer model can use deep neural networks to generate sounds at the level of individual samples. Learning directly from data, the neural synthesizer model can provide intuitive control over timbre and dynamics and enable exploration of new sounds that would be difficult or impossible to produce with a hand-tuned synthesizer. As one example, the neural synthesizer model can be a neural synthesis autoencoder that includes an encoder model that learns embeddings descriptive of musical characteristics and an autoregressive decoder model that is conditioned on the embedding to autoregressively generate musical waveforms that have the musical characteristics one audio sample at a time.