Patents by Inventor Cinzia Traboni

Cinzia Traboni has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • HCV replicons containing NS5B from genotype 2B
    Patent number: 8354518
    Abstract: The present invention features methods for enhancing the ability of a genotype 2b NS5B sequence to function in a replicon, for producing replicons containing a functional genotype 2b NS5B, and for using replicons to measure the ability of a compound to affect HCV replication that is sustained with the genotype 2b polymerase. Also featured is a genotype 1b NS4B adaptive mutation. The ability to produce replicons containing a functional genotype 2b NS5B is illustrated by the production of chimeric replicons based on HCV genotype 1b where substantially all the NS5B sequence is replaced with a genotype 2b NS5B.
    Type: Grant
    Filed: November 3, 2004
    Date of Patent: January 15, 2013
    Assignees: Merck Sharp & Dohme Corp., Istituto di Richerche di Biologia Molecolare P. Angeletti S.p.A.
    Inventors: Steven W. Ludmerer, Donald J. Graham, Robert L. LaFemina, Osvaldo A. Flores, Maura Pizzuti, Cinzia Traboni
  • Hcv replicons containing ns5b from genotype 2b
    Publication number: 20110250628
    Abstract: The present invention features methods for enhancing the ability of a genotype 2b NS5B sequence to function in a replicon, for producing replicons containing a functional genotype 2b NS5B, and for using replicons to measure the ability of a compound to affect HCV replication that is sustained with the genotype 2b polymerase. Also featured is a genotype 1b NS4B adaptive mutation. The ability to produce replicons containing a functional genotype 2b NS5B is illustrated by the production of chimeric replicons based on HCV genotype 1b where substantially all the NS5B sequence is replaced with a genotype 2b NS5B.
    Type: Application
    Filed: November 3, 2004
    Publication date: October 13, 2011
    Inventors: Steven W. Ludmerer, Donald J. Graham, Robert L. Lafemina, Osvaldo A. Flores, Maura Pizzuti, Cinzia Traboni
  • Gb virus b based replicons and replicon enhanced cells
    Publication number: 20050239205
    Abstract: The present invention features GBV-B replicons and replicon enhanced cells. A GBV-B replicon is an RNA molecule able to autonomously replicate in a cultured cell and produce detectable levels of one or more GBV-B proteins. GBV-B replicon enhanced cells are cells having an increased ability to maintain a GBV-B replicon.
    Type: Application
    Filed: January 13, 2003
    Publication date: October 27, 2005
    Inventors: Amedeo De Tomassi, Rita Graziani, Giacomo Paonessa, Cinzia Traboni