Patents by Inventor Clément Papadacci

Clément Papadacci has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 12465330
    Abstract: While 3D ultrasound imaging is becoming a powerful tool in medical field, the main drawback is the difficulty to image large 3D volume, mainly related to the dimensions of the 2D array of transducers. In order to not lose in spatial resolution, it is necessary to use an array of transducers, wherein the size of the transducers does not exceed the wavelength of the ultrasound wave. Such requirement leads to dimensions of array for imaging large 3D volume which are not reachable or at too high cost with the current technology. The present disclosure overcomes the above technology limitation by using greater transducers, and where each transducer has a reception surface with a curved shape or is fitted with an acoustic lens. Such configuration of transducers leads to 2D array of transducers suitable for imaging large 3D volume, as a brain or a heart, with high resolution and high sensitivity.
    Type: Grant
    Filed: April 1, 2022
    Date of Patent: November 11, 2025
    Assignees: INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, ECOLE SUPÉRIEURE DE PHYSIQUE ET DE CHIMIE INDUSTRIELLES DE LA VILLE DE PARIS
    Inventors: Clément Papadacci, Mickael Tanter, Hugues Favre, Mathieu Pernot
  • Patent number: 12408890
    Abstract: The present invention relates to the field of ultrasounds and imagining of the coronary blood flow of the heart. Patients with coronary microvascular dysfunction (CMD) have poor prognostic with significantly higher rates of cardiovascular events, including hospitalization for heart failure, sudden cardiac death, and myocardial infarction (MI). Despite the urgent clinical need, there are no non-ionizing and non-invasive techniques available in clinic to directly visualize the coronary microvasculature and assess the local coronary microvascular system. Flow imaging remains a difficult task to perform in the heart because of the fast movements of this organ. In order to overcome the limitations of actual imaging methods for the coronary blood flow, the inventors proposed an ultrasound ultrafast imaging method that automatically detect the time periods in which the myocardium velocity is low and estimate the coronary flow velocity and the tissue velocity from the same data acquisition.
    Type: Grant
    Filed: April 13, 2021
    Date of Patent: September 9, 2025
    Assignees: INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE—CNRS, ECOLE SUPERIEURE DE PHYSIQUE ET DE CHIMIE INDUSTRIELLES DE LA VILLE DE PARIS
    Inventors: Mathieu Pernot, Mickael Tanter, Clément Papadacci, Oscar Demeulenaere
  • Publication number: 20250271399
    Abstract: Nowadays, the interest to use ultrasound waves in medical field is well established. Indeed, the study of mechanical waves propagating in a medium allows usually to retrieve the properties of this medium as an organ such the heart. These elastic properties may be determined on the basis of propagation parameters as the velocity of shear waves propagating in the medium. The shear waves may be generated artificially or naturally (e.g. valves closure of the heart) in the medium. In both cases, the generation or/and observation of such shear waves require high complex and cost system as well as complex method for estimating with high precision the velocity of shear. The present disclosure overcomes the above drawbacks by proposing a new method and detection system for estimating in a simple and efficiency way the velocity of shear waves propagating in a medium, and with a high precision, requirement needed for determining the elastic properties of the medium.
    Type: Application
    Filed: April 19, 2023
    Publication date: August 28, 2025
    Inventors: Clément PAPADACCI, Mathieu PERNOT, Mickael TANTER
  • Publication number: 20250224513
    Abstract: Organ transplantation remains the only definitive therapeutic solution for many pathologies, but the number of currently available grafts is largely insufficient. A new approach is proposed to quantitatively evaluate isolated organs by ultrasound, which enables to safely admit more isolated organs as grafts available for transplantation. The isolated organ (2) is received in an organ preservation container (3) made of ultrasound transparent material, and the isolated organ is imaged by an ultrasound imaging probe (6) through the container (3). The ultrasound image of the isolated organ is used to determine a quantitative index representing viability of the isolated organ.
    Type: Application
    Filed: April 11, 2023
    Publication date: July 10, 2025
    Inventors: Mathieu PERNOT, Mickael TANTER, Oscar DEMEULENAERE, Clément PAPADACCI, Olivier PEREIRA PEDREIRA, René FERRERA
  • Patent number: 12138111
    Abstract: Because of the increase of the obesity related diseases, it is desirable to be able to detect a fatty liver and quantify the content in fat for the fatty liver. Known methods are biopsy and magnetic resonance imaging. However, biopsy is an invasive method and magnetic resonance imaging is a complicated method to carry out. The inventors propose a new ultrasonic method, which is more compliant with a regular control of the content in fat for the fatty liver for a subject. This method notably relies on a smart exploitation of the coherence properties of ultrasound pulses applied to the liver. This method has already been validated on sane subjects as providing accurate measurements, notably for fat content.
    Type: Grant
    Filed: September 25, 2020
    Date of Patent: November 12, 2024
    Assignees: INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE—CNRS, UNIVERSITÉ PARIS CITÉ, SORBONNE UNIVERSITÉ, ECOLE SUPERIEURE DE PHYSIQUE ET DE CHIMIE INDUSTRIELLES DE LA VILLE DE PARIS
    Inventors: Mathieu Pernot, Thomas Deffieux, Mickael Tanter, Clément Papadacci
  • Publication number: 20240180524
    Abstract: While 3D ultrasound imaging is becoming a powerful tool in medical field. the main drawback is the difficulty to image large 3D volume. mainly related to the dimensions of the 2D array of transducers. In order to not lose in spatial resolution, it is necessary to use an array of transducers. wherein the size of the transducers does not exceed the wavelength of the ultrasound wave. Such requirement leads to dimensions of array for imaging large 3D volume which are not reachable or at too high cost with the current technology. The present disclosure overcomes the above technology limitation by using greater transducers, and where each transducer has a reception surface with a curved shape or is fitted with an acoustic lens. Such configuration of transducers leads to 2D array of transducers suitable for imaging large 3D volume, as a brain or a heart. with high resolution and high sensitivity.
    Type: Application
    Filed: April 1, 2022
    Publication date: June 6, 2024
    Inventors: Clément PAPADACCI, Mickael TANTER, Hugues FARVE, Mathieu PERNOT
  • Patent number: 11766242
    Abstract: A method for mapping fibrous media by propagation of ultrasound from a set transducers, wherein: a number of unfocused incident ultrasonic waves having different wavefronts are emitted; the signals reverberated by the medium toward each transducer are captured; coherent signals respectively corresponding, for each transducer, to contributions coming from different fictitious focal points in the medium are determined; and then the orientation of the fibers is determined by comparing a spatial coherence between said coherent signals, in a plurality of directions.
    Type: Grant
    Filed: July 16, 2014
    Date of Patent: September 26, 2023
    Assignee: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)
    Inventors: Mickaël Tanter, Mathias Fink, Mathieu Pernot, Clément Papadacci
  • Publication number: 20230225698
    Abstract: The present invention relates to the field of ultrasounds and imagining of the coronary blood flow of the heart. Patients with coronary microvascular dysfunction (CMD) have poor prognostic with significantly higher rates of cardiovascular events, including hospitalization for heart failure, sudden cardiac death, and myocardial infarction (MI). Despite the urgent clinical need, there are no non-ionizing and non-invasive techniques available in clinic to directly visualize the coronary microvasculature and assess the local coronary microvascular system. Flow imaging remains a difficult task to perform in the heart because of the fast movements of this organ. In order to overcome the limitations of actual imaging methods for the coronary blood flow, the inventors proposed an ultrasound ultrafast imaging method that automatically detect the time periods in which the myocardium velocity is low and estimate the coronary flow velocity and the tissue velocity from the same data acquisition.
    Type: Application
    Filed: April 13, 2021
    Publication date: July 20, 2023
    Inventors: Mathieu PERNOT, Mickael TANTER, Clément PAPADACCI, Oscar DEMEULENAERE
  • Publication number: 20220346748
    Abstract: Because of the increase of the obesity related diseases, it is desirable to be able to detect a fatty liver and quantify the content in fat for the fatty liver. Known methods are biopsy and magnetic resonance imaging. However, biopsy is an invasive method and magnetic resonance imaging is a complicated method to carry out. The inventors propose a new ultrasonic method which is more compliant with a regular control of the content in fat for the fatty liver for a subject. This method notably relies on a smart exploitation of the coherence properties of ultrasound pulses applied to the liver. This method has already been validated on sane subjects as providing accurate measurements, notably for fat content.
    Type: Application
    Filed: September 25, 2020
    Publication date: November 3, 2022
    Inventors: Mathieu PERNOT, Thomas DEFFIEUX, Mickael TANTER, Clément PAPADACCI
  • Publication number: 20220346749
    Abstract: Because of the increase of the obesity related diseases, it is desirable to be able to detect a fatty liver and quantify the content in fat for the fatty liver. Known methods are biopsy and magnetic resonance imaging. However, biopsy is an invasive method and magnetic resonance imaging is a complicated method to carry out. The inventors propose a new ultrasonic method, which is more compliant with a regular control of the content in fat for the fatty liver for a subject. This method notably relies on a smart exploitation of the coherence properties of ultrasound pulses applied to the liver. This method has already been validated on sane subjects as providing accurate measurements, notably for fat content.
    Type: Application
    Filed: September 25, 2020
    Publication date: November 3, 2022
    Inventors: Mathieu PERNOT, Thomas DEFFIEUX, Mickael TANTER, Clément PAPADACCI
  • Publication number: 20210077065
    Abstract: The invention relates to the field of ultrasound imaging of the heart. 4D ultrafast ultrasound imaging of the heart is performed and may be used to compute major cardiac echo-graphic Flow and Tissue Doppler index indexes such as E/E?, E/Apex A, E?/A? with a single acquisition in a very quick time (e.g. with-in a heart beat) and in a reproducible way, independently of the experience of the operator.
    Type: Application
    Filed: February 18, 2019
    Publication date: March 18, 2021
    Inventors: Mathieu PERNOT, Clément PAPADACCI, Mickael TANTER
  • Publication number: 20160151046
    Abstract: A method for mapping fibrous media by propagation of ultrasound from a set transducers, wherein: a number of unfocused incident ultrasonic waves having different wavefronts are emitted; the signals reverberated by the medium toward each transducer are captured; coherent signals respectively corresponding, for each transducer, to contributions coming from different fictitious focal points in the medium are determined; and then the orientation of the fibers is determined by comparing a spatial coherence between said coherent signals, in a plurality of directions.
    Type: Application
    Filed: July 16, 2014
    Publication date: June 2, 2016
    Inventors: Mickaël Tanter, Mathias Fink, Mathieu Permot, Clément Papadacci