Patents by Inventor Claes B. Wollheim

Claes B. Wollheim has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS FOR TREATING DIABETES USING VDAC1 INHIBITORS
    Publication number: 20210130291
    Abstract: The present invention relates to compositions and methods for treating prediabetes and diabetes and delaying progression of the disease. The present invention uses molecules that specifically bind to and inhibit Voltage Dependent Anion Channel (VDAC1) that is expressed on the beta cells of diabetic subjects. Particularly, the present invention discloses the use of substituted piperazine and piperidine derivatives as specific inhibitors of VDAC1 for preventing the progression of and treating prediabetes and diabetes.
    Type: Application
    Filed: December 21, 2017
    Publication date: May 6, 2021
    Inventors: Albert SALEHI, Claes B. WOLLHEIM, Varda SHOSHAN-BARMATZ
  • NOVEL METHODS FOR PREVENTING OR TREATING DIABETES
    Publication number: 20130210143
    Abstract: The present application relates to an LRH-1 agonist for use in the prevention of progressive loss of pancreatic ?-cells. It also relates to an LRH-1 agonist for use in the preservation or restoration of pancreatic ?-cells. Further, it relates to an LRH-1 agonist for use in the prevention or treatment of type I diabetes, the increment of survival of pancreatic ?-cells, the increment of the performance of pancreatic ?-cells, the increment of the survival of a ?-cell graft, the in vitro preservation of pancreatic ?-cells, maintaining insulin secretion and/or in a method of transplanting pancreatic islet cells.
    Type: Application
    Filed: May 20, 2011
    Publication date: August 15, 2013
    Applicants: FUNDACION PUBLICA ANDALUZA PROGRESO Y SALUD
    Inventors: Luc St-Onge, Benoit R. Gauthier, Mathurin Baquie, Claes B. Wollheim