Patents by Inventor Clair Strohl
Clair Strohl has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240131063Abstract: The present invention relates to a spray dried plasma composition having one or more of the following characteristics: when reconstituted, largely amorphous and has no cholesterol crystals; when reconstituted, the mean size of large particulates is reduced; has low residual moisture; reconstitutes rapidly in under four minutes; highly stable when stored under refrigeration, at room temperature or at elevated temperatures and allows for storage for longer periods of time; when reconstituted, exhibits recovery of the most fragile of proteins, including von Willebrand's factor; when reconstituted with Sterile Water for Injection (SWFI), reconstituted plasma is at a pH that is near normal plasma pH, and does so without treatment or storage in CO2 or other pH adjustment.Type: ApplicationFiled: September 14, 2023Publication date: April 25, 2024Applicant: Velico Medical, Inc.Inventors: Jihae Sohn, Lisa A. Buckley, Mark A. Popovsky, Qiyong Peter Liu, Herman E. Snyder, Evan P. Ordway, William J. Merritt, Robert R. Andrews, Clair Strohl
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Publication number: 20240123368Abstract: The present invention relates to a spray dried plasma composition having one or more of the following characteristics: when reconstituted, largely amorphous and has no cholesterol crystals; when reconstituted, the number of large particulates is reduced; has low residual moisture; reconstitutes rapidly in under four minutes; highly stable when stored under refrigeration, at room temperature or at elevated temperatures and allows for storage for longer periods of time; when reconstituted, exhibits recovery of the most fragile of proteins, including von Willebrand's factor; when reconstituted with Sterile Water for Injection (SWFI), reconstituted plasma is at a pH that is near normal plasma pH, and does so without treatment or storage in CO2 or other pH adjustment; and when reconstituted, has reduced complement activation (C5A, C3A).Type: ApplicationFiled: January 17, 2023Publication date: April 18, 2024Applicant: Velico Medical, Inc.Inventors: Robert R. Andrews, Herman E. Snyder, William J. Merritt, Evan P. Ordway, Clair Strohl, Qiyong Peter Liu, Jihae Sohn
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Publication number: 20240123367Abstract: The present invention relates to a spray dried plasma composition having one or more of the following characteristics: when reconstituted, largely amorphous and has no cholesterol crystals; when reconstituted, the number of large particulates is reduced; has low residual moisture; reconstitutes rapidly in under four minutes; highly stable when stored under refrigeration, at room temperature or at elevated temperatures and allows for storage for longer periods of time; when reconstituted, exhibits recovery of the most fragile of proteins, including von Willebrand's factor; when reconstituted with Sterile Water for Injection (SWFI), reconstituted plasma is at a pH that is near normal plasma pH, and does so without treatment or storage in CO2 or other pH adjustment; and when reconstituted, has reduced complement activation (C5A, C3A).Type: ApplicationFiled: January 16, 2023Publication date: April 18, 2024Applicant: Velico Medical, Inc.Inventors: Robert R. Andrews, Herman E. Snyder, William J. Merritt, Evan P. Ordway, Clair Strohl
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Publication number: 20240109000Abstract: The present invention relates to a spray dried plasma composition having one or more of the following characteristics: when reconstituted, largely amorphous and has no cholesterol crystals; when reconstituted, the number of large particulates is reduced; has low residual moisture; reconstitutes rapidly in under four minutes; highly stable when stored under refrigeration, at room temperature or at elevated temperatures and allows for storage for longer periods of time; when reconstituted, exhibits recovery of the most fragile of proteins, including von Willebrand's factor; when reconstituted with Sterile Water for Injection (SWFI), reconstituted plasma is at a pH that is near normal plasma pH, and does so without treatment or storage in CO2 or other pH adjustment; and when reconstituted, has reduced complement activation (C5A, C3A).Type: ApplicationFiled: September 15, 2022Publication date: April 4, 2024Applicant: Velico Medical, Inc.Inventors: Qiyong Peter Liu, Herman E. Snyder, Kyle D. Erickson, Evan P. Ordway, William J. Merritt, Richard Meehan, Robert R. Andrews, Clair Strohl, Jihae Sohn
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Publication number: 20240110748Abstract: The present invention includes a spray drying disposable device for use in a spray drying system. The disposable has a spray drying head and a plasma drying chamber. The head has a spray dry nozzle assembly in fluid communication with the plasma source and the pressurized aerosol gas source. The pressurized gas flows in a vortex pattern that atomizes plasma droplets in the chamber. The head also includes a plenum has uniform air pressure of the drying gas. A baffle plate forms the floor of the plenum having drying gas jets that supply drying gas to the chamber. The atomized plasma droplets evaporate in the presence of the drying gas emitted from the jets to obtain dried plasma particles and humid air. A capture filter captures the dried plasma particles and allows the humid air to pass. The humid air passes through the gas outlet and the exhaust port.Type: ApplicationFiled: January 13, 2023Publication date: April 4, 2024Applicant: Velico Medical, Inc.Inventors: Robert R. Andrews, Herman E. Snyder, William J. Merritt, Evan P. Ordway, Clair Strohl, Russell Barron
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Publication number: 20240102730Abstract: The present invention includes a spray drying disposable device for use in a spray drying system. The disposable has a spray drying head and a plasma drying chamber. The head has a spray dry nozzle assembly in fluid communication with the plasma source and the pressurized aerosol gas source. The pressurized gas flows in a vortex pattern that atomizes plasma droplets in the chamber. The head also includes a plenum has uniform air pressure of the drying gas. A baffle plate forms the floor of the plenum having drying gas jets that supply drying gas to the chamber. The atomized plasma droplets evaporate in the presence of the drying gas emitted from the jets to obtain dried plasma particles and humid air. A capture filter captures the dried plasma particles and allows the humid air to pass. The humid air passes through the gas outlet and the exhaust port.Type: ApplicationFiled: January 13, 2023Publication date: March 28, 2024Applicant: Velico Medical, Inc.Inventors: Robert R. Andrews, Herman E. Snyder, William J. Merritt, Evan P. Ordway, Clair Strohl, Russell Barron
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Publication number: 20240091665Abstract: An alignment system that allows a spray drying disposable to align in both spray drying apparatus and finishing apparatus. The first instance is a locating arrangement wherein a locator is disposed on the spray drying apparatus and/or finishing apparatus and another locator is on the spray drying head of the disposable such that the locators allow for alignment of the disposable with the spray drying apparatus or finishing apparatus. A second instance of an alignment element includes a guide that is offset as positioned on the spray drying head of the disposable. Yet a third instance of the alignment arrangement relates to the gas exhaust port. In a fourth instance, the alignment system includes a positioning arrangement to reversibly attach the outer wall of the disposable to the finishing apparatus. In a fifth and sixth instance, a retaining device that retains the spray drying head in the spray drying apparatus and/or finishing apparatus.Type: ApplicationFiled: September 15, 2022Publication date: March 21, 2024Applicant: Velico Medical, Inc.Inventors: Robert R. Andrews, Herman E. Snyder, Kyle D. Erickson, William J. Merritt, Clair Strohl, Evan P. Ordway, Russell Barron
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Publication number: 20240091664Abstract: The present invention includes an ease-of-use system that allows the spray drying disposable device to fit (e.g., align) in both spray drying apparatus and the spray drying finishing apparatus to safely operate the system. The system includes locating arrangements between the spray drying disposable and the spray drying apparatus and/or spray drying finishing apparatus, a first retainer and second retainer, a shorter disposable device that allows for effective spray drying of plasma, a feedback indicators of correct installment, redundant indicators of correct installment, easily accessible operator controls and emergency shut offs.Type: ApplicationFiled: September 15, 2022Publication date: March 21, 2024Applicant: Velico Medical, Inc.Inventors: Robert R. Andrews, Herman E. Snyder, William J. Merritt, Kyle D. Erickson, Evan P. Ordway, Clair Strohl, Russell Barron
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Publication number: 20240091156Abstract: The present invention relates to spray drying plasma methodology that includes pretreating a donated liquid plasma unit, drying the liquid plasma using a spray drying apparatus with the spray drying disposable device that results in a disposable having the dried plasma, finishing the disposable using the finishing apparatus that is designed to seal and separate the disposable, and transform the disposable into a dried plasma unit. The methods of the present invention include storing the dried plasma unit and, when ready for use, reconstituting the dried plasma unit with reconstitution solution to obtain a plasma unit ready for transfusion into a recipient.Type: ApplicationFiled: September 15, 2022Publication date: March 21, 2024Applicant: Velico Medical, Inc.Inventors: Robert R. Andrews, Herman E. Snyder, William J. Merritt, Kyle D. Erickson, Evan P. Ordway, Clair Strohl, Russell Barron
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Publication number: 20240091666Abstract: The present invention relates to a spray dried plasma composition having one or more of the following characteristics: when reconstituted, largely amorphous and has no cholesterol crystals; when reconstituted, the number of large particulates is reduced; has low residual moisture; reconstitutes rapidly in under four minutes; highly stable when stored under refrigeration, at room temperature or at elevated temperatures and allows for storage for longer periods of time; when reconstituted, exhibits recovery of the most fragile of proteins, including von Willebrand's factor; when reconstituted with Sterile Water for Injection (SWFI), reconstituted plasma is at a pH that is near normal plasma pH, and does so without treatment or storage in CO2 or other pH adjustment; and when reconstituted, has reduced complement activation (C5A, C3A).Type: ApplicationFiled: January 17, 2023Publication date: March 21, 2024Applicant: Velico Medical, Inc.Inventors: Richard Meehan, Robert R. Andrews, Herman E. Snyder, William J. Merritt, Evan P. Ordway, Clair Strohl, Qiyong Peter Liu, Jihae Sohn
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Patent number: 11913722Abstract: The present invention includes a spray drying disposable device for use in a spray drying system. The disposable has a spray drying head and a plasma drying chamber. The head has a spray dry nozzle assembly in fluid communication with the plasma source and the pressurized aerosol gas source. The pressurized gas flows in a vortex pattern that atomizes plasma droplets in the chamber. The head also includes a plenum has uniform air pressure of the drying gas. A baffle plate forms the floor of the plenum having drying gas jets that supply drying gas to the chamber. The atomized plasma droplets evaporate in the presence of the drying gas emitted from the jets to obtain dried plasma particles and humid air. A capture filter captures the dried plasma particles and allows the humid air to pass. The humid air passes through the gas outlet and the exhaust port.Type: GrantFiled: January 13, 2023Date of Patent: February 27, 2024Assignee: Velico Medical, Inc.Inventors: Robert R. Andrews, Herman E. Snyder, William J. Merritt, Evan P. Ordway, Clair Strohl, Russell Barron
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Patent number: 11913723Abstract: The present invention includes a spray drying disposable device for use in a spray drying system. The disposable has a spray drying head and a plasma drying chamber. The head has a spray dry nozzle assembly in fluid communication with the plasma source and the pressurized aerosol gas source. The pressurized gas flows in a vortex pattern that atomizes plasma droplets in the chamber. The head also includes a plenum has uniform air pressure of the drying gas. A baffle plate forms the floor of the plenum having drying gas jets that supply drying gas to the chamber. The atomized plasma droplets evaporate in the presence of the drying gas emitted from the jets to obtain dried plasma particles and humid air. A capture filter captures the dried plasma particles and allows the humid air to pass. The humid air passes through the gas outlet and the exhaust port.Type: GrantFiled: January 13, 2023Date of Patent: February 27, 2024Assignee: Velico Medical, Inc.Inventors: Robert R. Andrews, Herman E. Snyder, William J. Merritt, Evan P. Ordway, Clair Strohl, Russell Barron
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Patent number: 11874262Abstract: A system for producing a high precision blended gas product (BGP), the system comprising: a supply of a volatile analyte in liquid form; a supply of an inert carrier gas; a supply of at least one diluent gas; an analyte gasifier (AG) subsystem for receiving the volatile analyte in liquid form, nebulizing the volatile analyte and mixing the nebulized volatile analyte with the inert carrier gas so as to form an analyte gas stream (AGS); and a gas mixer (GM) subsystem for receiving the AGS from the AG subsystem and mixing the AGS with the supply of at least one diluent gas so as to produce the BGP, wherein the GM subsystem comprises: a gas analyzer (GA) for receiving the AGS and analyzing the same; a gas proportioner for receiving the AGS from the GA, receiving the at least one diluent gas, and proportioning the AGS and the at least one diluent gas based on the results of the GA so as to provide a proportioned AGS and a proportioned at least one diluent gas; and a gas mixing chamber for receiving the proportioneType: GrantFiled: August 31, 2020Date of Patent: January 16, 2024Assignee: Automotive Coalition For Traffic Safety, Inc.Inventors: Neeraj Dalal, Brian E. Fratto, Kelly Ozdemir, Abdullatif Zaouk, Michael Willis, Clair Strohl
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Patent number: 11841189Abstract: The present invention includes a spray drying disposable device for use in a spray drying system. The disposable has a spray drying head and a plasma drying chamber. The head has a spray dry nozzle assembly in fluid communication with the plasma source and the pressurized aerosol gas source. The pressurized gas flows in a vortex pattern that atomizes plasma droplets in the chamber. The head also includes a plenum has uniform air pressure of the drying gas. A baffle plate forms the floor of the plenum having drying gas jets that supply drying gas to the chamber. The atomized plasma droplets evaporate in the presence of the drying gas emitted from the jets to obtain dried plasma particles and humid air. A capture filter captures the dried plasma particles and allows the humid air to pass. The humid air passes through the gas outlet and the exhaust port.Type: GrantFiled: September 15, 2022Date of Patent: December 12, 2023Assignee: Velico Medical, Inc.Inventors: Robert R. Andrews, Herman E. Snyder, William J. Merritt, Evan P. Ordway, Clair Strohl, Russell Barron
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Publication number: 20210063367Abstract: A system for producing a high precision blended gas product (BGP), the system comprising: a supply of a volatile analyte in liquid form; a supply of an inert carrier gas; a supply of at least one diluent gas; an analyte gasifier (AG) subsystem for receiving the volatile analyte in liquid form, nebulizing the volatile analyte and mixing the nebulized volatile analyte with the inert carrier gas so as to form an analyte gas stream (AGS); and a gas mixer (GM) subsystem for receiving the AGS from the AG subsystem and mixing the AGS with the supply of at least one diluent gas so as to produce the BGP, wherein the GM subsystem comprises: a gas analyzer (GA) for receiving the AGS and analyzing the same; a gas proportioner for receiving the AGS from the GA, receiving the at least one diluent gas, and proportioning the AGS and the at least one diluent gas based on the results of the GA so as to provide a proportioned AGS and a proportioned at least one diluent gas; and a gas mixing chamber for receiving the proportioneType: ApplicationFiled: August 31, 2020Publication date: March 4, 2021Inventors: Neeraj Dalal, Brian E. Fratto, Kelly Ozdemir, Abdullatif Zaouk, Michael Willis, Clair Strohl
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Patent number: 10874285Abstract: The present invention comprises the provision and use of a novel endoscopic device which is capable of stabilizing, straightening, expanding and/or flattening the side wall of a body lumen and/or body cavity so as to better present the side wall tissue for examination and/or treatment during an endoscopic procedure. The present invention also comprises the provision and use of a novel endoscopic device capable of steadying and/or stabilizing the distal tips and/or working ends of instruments inserted into a body lumen and/or body cavity, whereby to facilitate the use of those instruments.Type: GrantFiled: March 27, 2018Date of Patent: December 29, 2020Assignee: Cornell UniversityInventors: Jeffrey Milsom, Howard Riina, J. Frederick Cornhill, Edward Dickinson, Clair Strohl, James J. Mahoney, Jr., Pat Coppola
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Publication number: 20190069761Abstract: The present invention comprises the provision and use of a novel endoscopic device which is capable of stabilizing, straightening, expanding and/or flattening the side wall of a body lumen and/or body cavity so as to better present the side wall tissue for examination and/or treatment during an endoscopic procedure. The present invention also comprises the provision and use of a novel endoscopic device capable of steadying and/or stabilizing the distal tips and/or working ends of instruments inserted into a body lumen and/or body cavity, whereby to facilitate the use of those instruments.Type: ApplicationFiled: March 27, 2018Publication date: March 7, 2019Inventors: Jeffrey Milsom, Howard Riina, J. Frederick Cornhill, Edward Dickinson, Clair Strohl, James J. Mahoney, JR., Pat Coppola
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Patent number: 9924853Abstract: The present invention comprises the provision and use of a novel endoscopic device which is capable of stabilizing, straightening, expanding and/or flattening the side wall of a body lumen and/or body cavity so as to better present the side wall tissue for examination and/or treatment during an endoscopic procedure. The present invention also comprises the provision and use of a novel endoscopic device capable of steadying and/or stabilizing the distal tips and/or working ends of instruments inserted into a body lumen and/or body cavity, whereby to facilitate the use of those instruments.Type: GrantFiled: November 13, 2014Date of Patent: March 27, 2018Assignee: Cornell UniversityInventors: Jeffrey Milsom, Howard Riina, J. Frederick Cornhill, Edward Dickinson, Clair Strohl, James J. Mahoney, Pat Coppola
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Patent number: 9763665Abstract: An expandable substantially spherical structure for deployment in a blood vessel or other body lumen, comprising: an open frame formed out of a closed loop of filament and configured to assume (i) a collapsed configuration in the form of a substantially two-dimensional elongated loop structure so as to facilitate insertion into the blood vessel or other body lumen, and (ii) an expanded configuration in the form of a three-dimensional substantially spherical structure so as to facilitate retention at a site in the blood vessel or other body lumen; and a flow-restricting face carried by the open frame; wherein the open frame is configured so as to permit substantially normal flow therethrough when the open frame is in its expanded configuration, and further wherein the flow-restricting face is configured so as to restrict flow therethrough.Type: GrantFiled: February 28, 2014Date of Patent: September 19, 2017Assignee: Cornell UniversityInventors: Howard Riina, Robert Andrews, Clair Strohl, Jeffrey Milsom, J. Frederick Cornhill, Kevin Thomas Smith, David G. Lamphere, Tuan Anh Nguyen
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Publication number: 20150133774Abstract: The present invention comprises the provision and use of a novel endoscopic device which is capable of stabilizing, straightening, expanding and/or flattening the side wall of a body lumen and/or body cavity so as to better present the side wall tissue for examination and/or treatment during an endoscopic procedure. The present invention also comprises the provision and use of a novel endoscopic device capable of steadying and/or stabilizing the distal tips and/or working ends of instruments inserted into a body lumen and/or body cavity, whereby to facilitate the use of those instruments.Type: ApplicationFiled: November 13, 2014Publication date: May 14, 2015Inventors: Jeffrey Milsom, Howard Riina, J. Frederick Cornhill, Edward Dickinson, Clair Strohl, James Mahoney, Pat Coppola