Patents by Inventor Claire Bernhard

Claire Bernhard has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Biocompatible modular tetrazine platform
    Patent number: 11242359
    Abstract: A modular tetrazine platform, can be used as diagnostic, theragnostic agent and/or medicinal product. An inverse electron demand Diels-Alder reaction can be used for synthesizing bifunctionalized tetrazines, which can be obtained from monofunctionalised tetrazines.
    Type: Grant
    Filed: March 23, 2018
    Date of Patent: February 8, 2022
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITÉ DE BOURGOGNE
    Inventors: Victor Goncalves, Franck Denat, Claire Bernhard, Coline Canovas
  • BIOCOMPATIBLE MODULAR TETRAZINE PLATFORM
    Publication number: 20200354381
    Abstract: A modular tetrazine platform, can be used as diagnostic, theragnostic agent and/or medicinal product. An inverse electron demand Diels-Alder reaction can be used for synthesizing bifunctionalized tetrazines, which can be obtained from monofunctionalised tetrazines.
    Type: Application
    Filed: March 23, 2018
    Publication date: November 12, 2020
    Inventors: Victor Goncalves, Franck Denat, Claire Bernhard, Coline Canovas
  • Synthesis of imidazo[1,2-a]pyrazin-4-ium salts for the synthesis of 1,4,7-triazacyclononane (tacn) and N- and/or C- functionalized derivatives thereof
    Patent number: 9988388
    Abstract: A compound with formula (V?) the synthesis method for compound (V?), and its use for the preparation of 1,4,7-triazacyclononane (tacn) and N- and/or C-functionalized derivatives thereof, particularly compounds with formula (I) Also, metallic complexes comprising a ligand with formula (I) and a metal and their use for imaging.
    Type: Grant
    Filed: April 7, 2016
    Date of Patent: June 5, 2018
    Assignees: UNIVERSITE DE BOURGOGNE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)
    Inventors: Franck Denat, Pauline Desogere, Claire Bernhard, Yoann Rousselin, Frederic Boschetti
  • Synthesis of imidazo[1,2-a]pyrazin-4-ium salts for the synthesis of 1,4,7-triazacyclononane (tacn) and N- and/or C-functionalized derivatives thereof
    Patent number: 9981967
    Abstract: The present invention embodiments relate to a compound with formula (V?) The invention also relates in certain embodiments to the synthesis method for compound (V?) and its use for the preparation of 1,4,7-triazacyclononane (tacn) and N- and/or C-functionalized derivatives thereof, particularly compounds with formula (I) The invention also relates in certain embodiments to metallic complexes comprising a ligand with formula (I) and a metal and their use for imaging.
    Type: Grant
    Filed: November 13, 2013
    Date of Patent: May 29, 2018
    Assignees: UNIVERSITE DE BOURGOGNE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)
    Inventors: Franck Denat, Pauline Desogere, Claire Bernhard, Yoann Rousselin, Frederic Boschetti
  • SYNTHESIS OF IMIDAZO[1,2-a]PYRAZIN-4-IUM SALTS FOR THE SYNTHESIS OF 1,4,7-TRIAZACYCLONONANE (TACN) AND N- AND/OR C- FUNCTIONALIZED DERIVATIVES THEREOF
    Publication number: 20160222018
    Abstract: A compound with formula (V?) the synthesis method for compound (V?), and its use for the preparation of 1,4,7-triazacyclononane (tacn) and N- and/or C-functionalized derivatives thereof, particularly compounds with formula (I) Also, metallic complexes comprising a ligand with formula (I) and a metal and their use for imaging.
    Type: Application
    Filed: April 7, 2016
    Publication date: August 4, 2016
    Inventors: Franck DENAT, Pauline DESOGERE, Claire BERNHARD, Yoann Rousselin, Frederic BOSCHETTI
  • CLICKED SOMATOSTATIN CONJUGATED ANALOGS FOR BIOLOGICAL APPLICATIONS
    Publication number: 20140314670
    Abstract: The invention relate to the new conjugated somatostatin analogs of formula (I), wherein A- is H or TAG-B—, wherein —B— is 0 or a spacer, wherein TAG is a chelating agent (e.g. DOTA), a fluorescent dye, (e.g. Bodipy-B derivative, a Rho-damine-B derivative, a Fluorescein-B derivative, a Cyanine-B derivative, a Porphyrin-B derivative), a bimodal agent, or a cytotoxic agent (e.g. a doxorubicin derivative) wherein R1 is CI-C4 alkynyl radical when R2 is CI-C4 azido radical and viceversa and methods for preparing same, pharmaceutical compositions comprising them and their use in imaging and the treatment of cancer.
    Type: Application
    Filed: December 14, 2012
    Publication date: October 23, 2014
    Inventors: Débora D'Addona, Claire Bernhard, Anna Maria Rovero, Franck Denat, Michael Chorev
  • SYNTHESIS OF IMIDAZO[1,2-a]PYRAZIN-4-IUM SALTS FOR THE SYNTHESIS OF 1,4,7-TRIAZACYCLONONANE (TACN) AND N- AND/OR C-FUNCTIONALIZED DERIVATIVES THEREOF
    Publication number: 20140142298
    Abstract: The present invention embodiments relate to a compound with formula (V?) The invention also relates in certain embodiments to the synthesis method for compound (V?) and its use for the preparation of 1,4,7-triazacyclononane (tacn) and N- and/or C-functionalized derivatives thereof, particularly compounds with formula (I) The invention also relates in certain embodiments to metallic complexes comprising a ligand with formula (I) and a metal and their use for imaging.
    Type: Application
    Filed: November 13, 2013
    Publication date: May 22, 2014
    Applicants: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), UNIVERSITE DE BOURGOGNE
    Inventors: Franck Denat, Pauline Desogere, Claire Bernhard, Yoann Rousselin, Frederic Boschetti