Patents by Inventor Claire Bonfils

Claire Bonfils has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Assay for efficacy of histone deacetylase inhibitors
    Publication number: 20070292351
    Abstract: The invention provides methods for assessing the efficacy of histone deacetylase inhibitors using biomarkers which can be used in human clinical trials and which are more quantitative, easy to be used and more relevant to clinical outcome for PD monitoring than existing assays. The method according to the invention utilizes biomarkers from blood cells from patients treated with HDAC inhibitors which are easy to assay.
    Type: Application
    Filed: May 25, 2007
    Publication date: December 20, 2007
    Inventors: Zuomei Li, Christiane Maroun, Jianhong Liu, Jeffrey Besterman, Claire Bonfils
  • Histone deacetylase whole cell enzyme assay
    Publication number: 20060063210
    Abstract: The invention relates to enzymatic assays for protein deacetylases. More particularly, the invention relates to such assays utilizing whole cells. The invention provides assays which allow assessment of the level of a protein deacetylase activity in whole cells taken directly from the body of the mammal.
    Type: Application
    Filed: September 21, 2005
    Publication date: March 23, 2006
    Inventors: Zuomei Li, Jeffrey Besterman, Claire Bonfils
  • Inhibition of specific histone deacetylase isoforms
    Publication number: 20040266718
    Abstract: This invention relates to the inhibition of histone deacetylase expression and enzymatic activity. The invention provides methods and reagents for inhibiting specific histone deacetylase (HDAC) isoforms by inhibiting expression at the nucleic acid level or enzymatic activity at the protein level.
    Type: Application
    Filed: June 17, 2004
    Publication date: December 30, 2004
    Inventors: Zuomei Li, Claire Bonfils, Jeffrey Besterman
  • Methods for specifically inhibiting histone deacetylase-7 and 8
    Publication number: 20040072770
    Abstract: This invention relates to the inhibition of histone deacetylase (HDAC) expression and enzymatic activity. The invention provides methods and reagents for inhibiting HDAC-7 and HDAC-8 by inhibiting expression at the nucleic acid level or inhibiting enzymatic activity at the protein level.
    Type: Application
    Filed: July 3, 2002
    Publication date: April 15, 2004
    Inventors: Jeffrey M. Besterman, Zuomei Li, Daniel Delorme, Claire Bonfils
  • Methods for inhibiting histone deacetylase-4
    Publication number: 20030152557
    Abstract: This invention relates to the inhibition of histone deacetylase (HDAC) expression and enzymatic activity. The invention provides methods and reagents for inhibiting HDAC-4 and HDAC-1 by inhibiting expression at the nucleic acid level or inhibiting enzymatic activity at the protein level.
    Type: Application
    Filed: January 14, 2002
    Publication date: August 14, 2003
    Inventors: Jeffrey M. Besterman, Claire Bonfils, Zuomei Li, Soon Hyung Woo, Arkadii Vaisburg, Daniel Delorme, Marielle Fournel, Rico Lavoie
  • Methods for specifically inhibiting histone deacetylase-4
    Publication number: 20030148970
    Abstract: This invention relates to the inhibition of histone deacetylase (HDAC) expression and enzymatic activity. The invention provides methods and reagents for inhibiting HDAC-4 and HDAC-1 by inhibiting expression at the nucleic acid level or inhibiting enzymatic activity at the protein level.
    Type: Application
    Filed: January 14, 2002
    Publication date: August 7, 2003
    Inventors: Jeffrey M. Besterman, Claire Bonfils, Zuomei Li, Soon Hyung Woo, Arkadii Vaisburg, Daniel Delorme, Marielle Fournel, Rico Lavoie
  • Antisense oligonucleotide inhibition of specific histone deacetylase isoforms
    Publication number: 20020137162
    Abstract: This invention relates to the inhibition of histone deacetylase expression and enzymatic activity. The invention provides methods and reagents for inhibiting specific histone deacetylase (HDAC) isoforms by inhibiting expression at the nucleic acid level or enzymatic activity at the protein level.
    Type: Application
    Filed: March 26, 2001
    Publication date: September 26, 2002
    Inventors: Zuomei Li, Claire Bonfils, Jeffrey M. Besterman
  • Antisense oligonucleotide inhibition of specific histone deacetylase isoforms
    Publication number: 20020061860
    Abstract: This invention relates to the inhibition of histone deacetylase expression and enzymatic activity. The invention provides methods and reagents for inhibiting specific histone deacetylase (HDAC) isoforms by inhibiting expression at the nucleic acid level or enzymatic activity at the protein level.
    Type: Application
    Filed: August 6, 2001
    Publication date: May 23, 2002
    Inventors: Zuomei Li, Claire Bonfils, Jeffrey Besterman