Abstract: Apparatus, methods and systems for treating venous occlusive disease are provided. Generally, devices include a removable soft extension member that is adapted to be mounted at a proximal end of a therapeutic vacuum chamber. The soft extension member includes a proximal end composed of a tissue contacting portion configured to receive a tissue to be treated, and a distal end composed of a collar configured to be mounted onto an exterior surface of a vacuum chamber. Apparatus, methods and systems for increasing penile and cavernosal tumescence by application of a vacuum are also provided.

Abstract: Apparatus, methods and systems for treating venous occlusive disease are provided. Generally, devices include a soft extension member that is adapted to be mounted at a proximal end of a therapeutic vacuum device. The soft extension member includes a proximal end composed of a tissue contacting portion configured to receive a tissue to be treated, and a distal end composed of a collar configured to be mounted onto an exterior surface of a vacuum chamber. Apparatus, methods and systems for increasing clitoral and cavernosal tumescence by application of a vacuum are also provided.

Abstract: Apparatus, methods and systems for treating venous occlusive disease are provided. Generally, devices include a soft extension member that is adapted to be mounted at a proximal end of a therapeutic vacuum device. The soft extension member includes a proximal end composed of a tissue contacting portion configured to receive a tissue to be treated, and a distal end composed of a collar configured to be mounted onto an exterior surface of a vacuum chamber. Apparatus, methods and systems for increasing clitoral and cavernosal tumescence by application of a vacuum are also provided.

Abstract: Apparatus, methods and systems for treating venous occlusive disease are provided. Generally, devices include a removable soft extension member that is adapted to be mounted at a proximal end of a therapeutic vacuum chamber. The soft extension member includes a proximal end composed of a tissue contacting portion configured to receive a tissue to be treated, and a distal end composed of a collar configured to be mounted onto an exterior surface of a vacuum chamber. Apparatus, methods and systems for increasing penile and cavernosal tumescence by application of a vacuum are also provided.

Abstract: Particle functionalization systems including one or more of: a target of a material; an energetic ion and/or electron source providing accelerated ions and electrons to the target; a potential that is applied to at least the target and that causes ions and/or electrons from the ionized gas to impact a surface of the target and release atoms of the material; at least one magnet providing a magnetic field that controls movement of the ions and electrons and nucleation, formation and growth of particles from the released atoms; and a particle collection device that collects particles, the collection device comprising a substrate and a polymeric functionalization coating disposed on the substrate, wherein particles impinge upon and form bonds with molecules of the functionalization coating. Methods of preparing functionalized particles, functionalized particle compositions, and kits including functionalized particles are also described.

Abstract: A multi-surface nanoparticle source includes a first end having an inlet configured to receive a flow of gas, a second end comprising an outlet through which nanoparticles exit the nanoparticle source, and two or more targets spaced apart and arranged about an axis extending from the first end to the second end. At least at least one of the targets is hollow, and the inlet is arranged to direct a flow of the gas through the hollow target, between at least two of the targets, or both. The gas impacts the targets, releasing atoms from the target and through the second end. The targets may be arranged lengthwise and concentrically about the axis. In some cases, a multi-surface nanoparticle source includes one or more magnets. Nanoparticles formed with a multi-surface nanoparticle deposition system may be homogeneous or have a core-shell structure.

Abstract: Particle functionalization systems including one or more of: a target of a material; an energetic ion and/or electron source providing accelerated ions and electrons to the target; a potential that is applied to at least the target and that causes ions and/or electrons from the ionized gas to impact a surface of the target and release atoms of the material; at least one magnet providing a magnetic field that controls movement of the ions and electrons and nucleation, formation and growth of particles from the released atoms; and a particle collection device that collects particles, the collection device comprising a substrate and a polymeric functionalization coating disposed on the substrate, wherein particles impinge upon and form bonds with molecules of the functionalization coating. Methods of preparing functionalized particles, functionalized particle compositions, and kits including functionalized particles are also described.

Abstract: A system for ultrasonically placing and monitoring an endotracheal tube within a patient. The system includes an endotracheal tube having a proximal and a distal end and a ventilation lumen disposed there through. A vibration mechanism is coupled to the endotracheal tube. One ultrasonic transducer is located outside the patient's body. An ultrasonic imaging apparatus is coupled to the ultrasonic transducer for digitalizing the endotracheal tube within the body.

Abstract: Apparatus for treatment of anatomical structure having a lumen includes a pressure differential device adapted to move the anatomical structure to a desired configuration for treatment by creating a pressure differential with respect to the lumen of the anatomical structure, a biological adhesive dispenser, operably coupled with the pressure differential device, and biological adhesive adapted for dispensing by the dispenser and adapted to stabilize the anatomical structure in the desired configuration. A dispenser for applying adhesive to an anatomical structure includes a penetrator adapted to rotate into or around the anatomical structure, and a driver adapted to rotate in one direction to rotate the penetrator into or around the anatomical structure, and adapted to rotate in a direction opposite to the one direction to withdraw the penetrator from the anatomical structure, wherein the penetrator is adapted to apply adhesive to the anatomical structure.