Abstract: The present invention is based on the surprising finding of the property of promoting myelination of activators of histone deacetylase (HDAC) 1 and 2. In particular, such activators have the capacity of accelerating and increasing remyelination after lesions to the myelin of nerve cells of the peripheral and central nervous systems. The present inventor found that HDAC2 deacetylates eEF1A1 and thereby prevents the latter from removing outside the nucleus key inducers of myelin genes transcription. The HDAC1/2 activators are useful in the treatment of diseases associated with demyelination, such as Multiple Sclerosis.

Abstract: The present invention is based on the surprising finding of the property of promoting myelination of activators of histone deacetylase (HDAC) 1 and 2. In particular, such activators have the capacity of accelerating and increasing remyelination after lesions to the myelin of nerve cells of the peripheral and central nervous systems. The present inventor found that HDAC2 deacetylates eEF1A1 and thereby prevents the latter from removing outside the nucleus key inducers of myelin genes transcription. The HDAC1/2 activators are useful in the treatment of diseases associated with demyelination, such as Multiple Sclerosis.

Abstract: A multi-purpose apron includes a main apron portion for protecting a user's clothes, the user, and/or any surfaces that the user is working on. For example, the main apron portion may be a soft cloth for protecting furniture and cars being serviced by the user as well as protecting the user's clothes. The main apron portion extends from the waist of the user to the user's knees. The apron further includes an extension having a material different from the main apron portion and a pocket for the user to place their hand in to use on the surface being worked on. For example, the extension may have a material selected for dusting furniture, or a material selected to wipe surfaces dry and clean.