Patents by Inventor Claire Marie Stoffers

Claire Marie Stoffers has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS AND COMPOSITIONS FOR EDITING THE B2M LOCUS IN B CELLS
    Publication number: 20230272431
    Abstract: Some embodiments of the methods and compositions provided herein include preparing modified B cells. In some embodiments, an endogenous beta-2 microglobulin (B2M) gene in a B cell is modified. Some embodiments relate to increasing the resistance of modified B cells to killing by allogeneic immune cells. In some embodiments, the endogenous B2M gene is inactivated increasing the resistance of the modified B cell to killing by allogeneic immune cells. In some embodiments, a replacement MHC-I is inserted into an inactivated endogenous B2M gene increasing the resistance of the modified B cell to killing by allogeneic immune cells. Some embodiments include enriching for successfully modified cells.
    Type: Application
    Filed: June 30, 2021
    Publication date: August 31, 2023
    Inventors: David J. Rawlings, Richard G. James, Claire Marie Stoffers, Peter J. Cook