Patents by Inventor Claire S. Jacobs

Claire S. Jacobs has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Inhibitors for steroid response elements and RNA polymerase II and related methods
    Patent number: 9630950
    Abstract: The present invention relates to polyamides capable of inhibiting ARE-, GRE- and ERE-mediated gene regulation in cells. The present invention also relates to polyamides capable of modulating the activity of RNA polymerase II and p53. The invention also relates to methods to treat diseases related to ARE-, GRE- and ERE-mediated gene regulation and to RNA polymerase II and p53 activity.
    Type: Grant
    Filed: September 13, 2013
    Date of Patent: April 25, 2017
    Assignee: California Institute of Technology
    Inventors: Peter B. Dervan, Nicholas G. Nickols, Claire S. Jacobs, Michelle E. Farkas, Daniel A. Harki
  • Polyamides with tail structures capable of binding DNA
    Patent number: 7935530
    Abstract: The present invention relates to polyamides with a tail comprising a linker and an end-group. A preferred end-group is isophthalic acid and derivatives thereof. Polyamides of the invention are capable of entering the nucleus of cells. Polyamides of the invention are capable of selectively binding DNA. The invention also relates to methods of using the polyamides in therapy and research.
    Type: Grant
    Filed: November 28, 2007
    Date of Patent: May 3, 2011
    Assignee: California Institute of Technology
    Inventors: Peter B. Dervan, Claire S. Jacobs, Nicholas G. Nickols, Daniel A. Harki
  • Polyamides with tail structures
    Publication number: 20080269138
    Abstract: The present invention relates to polyamides with a tail comprising a linker and an end-group. A preferred end-group is isophthalic acid and derivatives thereof. Polyamides of the invention are capable of entering the nucleus of cells. Polyamides of the invention are capable of selectively binding DNA. The invention also relates to methods of using the polyamides in therapy and research.
    Type: Application
    Filed: November 28, 2007
    Publication date: October 30, 2008
    Inventors: Peter B. Dervan, Claire S. Jacobs, Nicholas G. Nickols, Daniel A. Harki