Patents by Inventor Claire Vieille
Claire Vieille has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 7867740Abstract: Nucleic acids encoding Thermotoga maritima mannitol dehydrogenase and the Thermotoga maritima mannitol dehydrogenase polypeptide are disclosed. Further provided are an electrochemical bioreactor system and a bioreactor electrode that can be used to convert glucose or fructose to mannitol.Type: GrantFiled: August 10, 2007Date of Patent: January 11, 2011Assignee: Board of Trustees of Michigan State UniversityInventors: Claire Vieille, Seung Hoon Song, J. Gregory Zeikus
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Patent number: 7750135Abstract: The present invention relates to compositions and methods utilizing thermostable and novel alcohol dehydrogenase enzymes for biosynthesizing chiral specific molecules for use as precursor molecules in synthesizing pharmaceutical compounds. Particularly, in preferred embodiments, the invention relates to directed engineering of an enzymatic catalytic site of an alcohol dehydrogenase enzyme gene for enhancing enantioselectivity for (S)-enantiomer substrate catalytic activity for providing aryl (S)-enantiomer products in stereomeric excess.Type: GrantFiled: July 27, 2007Date of Patent: July 6, 2010Assignee: Board of Trustees of Michigan State UniversityInventors: J. Gregory Zeikus, Karla I. Ziegelmann-Fjeld, Claire Vieille
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Publication number: 20080220487Abstract: The present invention relates to compositions and methods utilizing thermostable and novel alcohol dehydrogenase enzymes for biosynthesizing chiral specific molecules for use as precursor molecules in synthesizing pharmaceutical compounds. Particularly, in preferred embodiments, the invention relates to directed engineering of an enzymatic catalytic site of an alcohol dehydrogenase enzyme gene for enhancing enantioselectivity for (S)-enantiomer substrate catalytic activity for providing aryl (S)-enantiomer products in stereomeric excess.Type: ApplicationFiled: July 27, 2007Publication date: September 11, 2008Inventors: J. Gregory Zeikus, Karla I. Ziegelmann-Fjeld, Claire Vieille
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Publication number: 20080176283Abstract: The present invention relates to compositions and methods for providing a recombinant thermostable Thermotoga neapolitana alkaline phosphatase enzyme. More particularly, the invention relates to engineering Escherichia coli with T. neapolitana alkaline phosphatase gene expression vectors for providing an inducible system for thermostable enzyme production, wherein the expressed enzyme is readily soluble with a high degree of activity. These methods provide for commercial quantities of a thermostable alkaline phosphatase enzyme.Type: ApplicationFiled: September 28, 2007Publication date: July 24, 2008Applicant: Michigan State UniversityInventors: Claire Vieille, J. Gregory Zeikus, Maris Laivenieks
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Publication number: 20080035490Abstract: Nucleic acids encoding Thermotoga maritima mannitol dehydrogenase and the Thermotoga maritima mannitol dehydrogenase polypeptide are disclosed. Further provided are an electrochemical bioreactor system and a bioreactor electrode that can be used to convert glucose or fructose to mannitol.Type: ApplicationFiled: August 10, 2007Publication date: February 14, 2008Applicant: Board of Trustees of Michigan State UniversityInventors: Claire Vieille, Seung Song, J. Zeikus
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Patent number: 7198933Abstract: The present invention provides novel isolated polynucleotides encoding a novel xylose isomerases capable of catalyzing the conversion of glucose to fructose and nucleic acids encoding for such isomerase. The present invention also provides a method of producing the xylose isomerase enzymes employing DNA encoding for the enzymes, plasmids containing the DNA, and bacteria into which the plasmids have been inserted and which produce the enzymes.Type: GrantFiled: January 21, 2003Date of Patent: April 3, 2007Assignee: Board of Trustees of Michigan State UniversityInventors: J. Gregory Zeikus, Dinlaka Sriprapundh, Claire Vieille
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Patent number: 7195918Abstract: An Actinobacillus succinogenes plasmid vector which provides a means to overexpress proteins in A. succinogenes. The plasmid can be transformed efficiently by electroporation, and replicates in a stable manner in A. succinogenes. The plasmid comprises at least one marker gene, operably linked to a first promoter functional in Actinobacillus succinogenes, an origin of replication functional in Actinobacillus succinogenes, a second promoter isolated from Actinobacillus succinogenes, and a cloning site downstream from the second promoter. Plasmids pLGZ901, pLGZ920, pLGZ921, and pLGZ922 are disclosed. The pckA gene polypeptide sequence and nucleic acid sequence of Actinobacillus succinogenes, including the promoter and ribosome binding site, is disclosed. Furthermore, a method for producing a recombinant Actinobacillus succinogenes is described, including a method of transformation.Type: GrantFiled: January 25, 2005Date of Patent: March 27, 2007Assignee: Board of Trustees of Michigan State UniversityInventors: J. Gregory Zeikus, Maris Laivenieks, Claire Vieille, Pil Kim
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Patent number: 7192761Abstract: An Actinobacillus succinogenes plasmid vector which provides a means to overexpress proteins in A. succinogenes. The plasmid can be transformed efficiently by electroporation, and replicates in a stable manner in A. succinogenes. The plasmid comprises at least one marker gene, operably linked to a first promoter functional in Actinobacillus succinogenes, an origin of replication functional in Actinobacillus succinogenes, a second promoter isolated from Actinobacillus succinogenes, and a cloning site downstream from the second promoter. Plasmids pLGZ901, pLGZ920, pLGZ921, and pLGZ922 are disclosed. The pckA gene polypeptide sequence and nucleic acid sequence of Actinobacillus succinogenes, including the promoter and ribosome binding site, is disclosed. Furthermore, a method for producing a recombinant Actinobacillus succinogenes is described, including a method of transformation.Type: GrantFiled: January 25, 2005Date of Patent: March 20, 2007Assignee: Board of Trustees of Michigan State UniversityInventors: J. Gregory Zeikus, Maris Laivenieks, Claire Vieille, Pil Kim
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Patent number: 7163812Abstract: An Actinobacillus succinogenes plasmid vector which provides a means to overexpress proteins in A. succinogenes. The plasmid can be transformed efficiently by electroporation, and replicates in a stable manner in A. succinogenes. The plasmid comprises at least one marker gene, operably linked to a first promoter functional in Actinobacillus succinogenes, an origin of replication functional in Actinobacillus succinogenes, a second promoter isolated from Actinobacillus succinogenes, and a cloning site downstream from the second promoter. Plasmids pLGZ901, pLGZ920, pLGZ921, and pLGZ922 are disclosed. The pckA gene polypeptide sequence and nucleic acid sequence of Actinobacillus succinogenes, including the promoter and ribosome binding site, is disclosed. Furthermore, a method for producing a recombinant Actinobacillus succinogenes is described, including a method of transformation.Type: GrantFiled: August 5, 2004Date of Patent: January 16, 2007Assignee: Board of Trustees of Michigan State UniversityInventors: J. Gregory Zeikus, Maris Laivenieks, Claire Vieille, Pil Kim
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Patent number: 7105329Abstract: An Actinobacillus succinogenes plasmid vector which provides a means to overexpress proteins in A. succinogenes. The plasmid can be transformed efficiently by electroporation, and replicates in a stable manner in A. succinogenes. The plasmid comprises at least one marker gene, operably linked to a first promoter functional in Actinobacillus succinogenes, an origin of replication functional in Actinobacillus succinogenes, a second promoter isolated from Actinobacillus succinogenes, and a cloning site downstream from the second promoter. Plasmids pLGZ901, pLGZ920, pLGZ921, and pLGZ922 are disclosed. The pckA gene polypeptide sequence and nucleic acid sequence of Actinobacillus succinogenes, including the promoter and ribosome binding site, is disclosed. Furthermore, a method for producing a recombinant Actinobacillus succinogenes is described, including a method of transformation.Type: GrantFiled: January 25, 2005Date of Patent: September 12, 2006Assignee: Board of Trustees of Michigan State UniversityInventors: J. Gregory Zeikus, Maris Laivenieks, Claire Vieille, Pil Kim
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Publication number: 20050164347Abstract: An Actinobacillus succinogenes plasmid vector which provides a means to overexpress proteins in A. succinogenes. The plasmid can be transformed efficiently by electroporation, and replicates in a stable manner in A. succinogenes. The plasmid comprises at least one marker gene, operably linked to a first promoter functional in Actinobacillus succinogenes, an origin of replication functional in Actinobacillus succinogenes, a second promoter isolated from Actinobacillus succinogenes, and a cloning site downstream from the second promoter. Plasmids pLGZ901, pLGZ920, pLGZ921, and pLGZ922 are disclosed. The pckA gene polypeptide sequence and nucleic acid sequence of Actinobacillus succinogenes, including the promoter and ribosome binding site, is disclosed. Furthermore, a method for producing a recombinant Actinobacillus succinogenes is described, including a method of transformation.Type: ApplicationFiled: January 25, 2005Publication date: July 28, 2005Applicant: Board of Trustees of Michigan State UniversityInventors: J. Zeikus, Maris Laivenieks, Claire Vieille, Pil Kim
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Publication number: 20050164360Abstract: An Actinobacillus succinogenes plasmid vector which provides a means to overexpress proteins in A. succinogenes. The plasmid can be transformed efficiently by electroporation, and replicates in a stable manner in A. succinogenes. The plasmid comprises at least one marker gene, operably linked to a first promoter functional in Actinobacillus succinogenes, an origin of replication functional in Actinobacillus succinogenes, a second promoter isolated from Actinobacillus succinogenes, and a cloning site downstream from the second promoter. Plasmids pLGZ901, pLGZ920, pLGZ921, and pLGZ922 are disclosed. The pckA gene polypeptide sequence and nucleic acid sequence of Actinobacillus succinogenes, including the promoter and ribosome binding site, is disclosed. Furthermore, a method for producing a recombinant Actinobacillus succinogenes is described, including a method of transformation.Type: ApplicationFiled: January 25, 2005Publication date: July 28, 2005Applicant: Board of Trustees of Michigan State UniversityInventors: J. Zeikus, Maris Laivenieks, Claire Vieille, Pil Kim
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Publication number: 20050164346Abstract: An Actinobacillus succinogenes plasmid vector which provides a means to overexpress proteins in A. succinogenes. The plasmid can be transformed efficiently by electroporation, and replicates in a stable manner in A. succinogenes. The plasmid comprises at least one marker gene, operably linked to a first promoter functional in Actinobacillus succinogenes, an origin of replication functional in Actinobacillus succinogenes, a second promoter isolated from Actinobacillus succinogenes, and a cloning site downstream from the second promoter. Plasmids pLGZ901, pLGZ920, pLGZ921, and pLGZ922 are disclosed. The pckA gene polypeptide sequence and nucleic acid sequence of Actinobacillus succinogenes, including the promoter and ribosome binding site, is disclosed. Furthermore, a method for producing a recombinant Actinobacillus succinogenes is described, including a method of transformation.Type: ApplicationFiled: January 25, 2005Publication date: July 28, 2005Applicant: Board of Trustees of Michigan State UniversityInventors: J. Zeikus, Maris Laivenieks, Claire Vieille, Pil Kim
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Publication number: 20050032195Abstract: An Actinobacillus succinogenes plasmid vector which provides a means to overexpress proteins in A. succinogenes. The plasmid can be transformed efficiently by electroporation, and replicates in a stable manner in A. succinogenes. The plasmid comprises at least one marker gene, operably linked to a first promoter functional in Actinobacillus succinogenes, an origin of replication functional in Actinobacillus succinogenes, a second promoter isolated from Actinobacillus succinogenes, and a cloning site downstream from the second promoter. Plasmids pLGZ901, pLGZ920, pLGZ921, and pLGZ922 are disclosed. The pckA gene polypeptide sequence and nucleic acid sequence of Actinobacillus succinogenes, including the promoter and ribosome binding site, is disclosed. Furthermore, a method for producing a recombinant Actinobacillus succinogenes is described, including a method of transformation.Type: ApplicationFiled: August 5, 2004Publication date: February 10, 2005Applicant: Board of Trustees of Michigan State UniversityInventors: J. Zeikus, Maris Laivenieks, Claire Vieille, Pil Kim
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Publication number: 20030166172Abstract: The present invention provides novel isolated polynucleotides encoding a novel xylose isomerases capable of catalyzing the conversion of glucose to fructose and nucleic acids encoding for such isomerase. The present invention also provides a method of producing the xylose isomerase enzymes employing DNA encoding for the enzymes, plasmids containing the DNA, and bacteria into which the plasmids have been inserted and which produce the enzymes.Type: ApplicationFiled: January 21, 2003Publication date: September 4, 2003Applicant: Board of Trustees of MICHIGAN STATE UNIVERSITYInventors: J. Gregory Zeikus, Dinlaka Sriprapundh, Claire Vieille
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Patent number: 5656497Abstract: The present invention describes the cloning and expression of a hyperthermostable xylose isomerase gene in an industrial host and the heat facilitated purification of the enzyme. The hyperthermostable enzyme has unique features sought by the fructose syrup industry.Type: GrantFiled: November 15, 1995Date of Patent: August 12, 1997Assignee: Michigan State UniversityInventors: Joseph Gregory Zeikus, Claire Vieille