Patents by Inventor Clancey Buchanan Wolf

Clancey Buchanan Wolf has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Protein-based nanoparticle vaccine for metapneumovirus
    Patent number: 11806394
    Abstract: Provided are virus-like particle vaccines for human metapneumovirus (hMPV) in which the ectodomain of hMPV F protein is linked to, and thereby displayed on, a symmetric protein-based virus-like particle. For example, the vaccine antigen may be a N-terminal fusion of the ectodomain of hMPV F protein to a protein having a multimerization domain for a one- or two-component virus-like particle, such as a two-component icosahedral virus-like particle. Further provided are vaccine compositions, methods of manufacturing, and methods of use, e.g., immunizing a subject to generate a protective immune response to hMPV.
    Type: Grant
    Filed: March 24, 2023
    Date of Patent: November 7, 2023
    Assignee: Icosavax, Inc.
    Inventors: Andrew Lawrence Feldhaus, Douglas Andrew Holtzman, Clancey Buchanan Wolf
  • PROTEIN-BASED NANOPARTICLE VACCINE FOR METAPNEUMOVIRUS
    Publication number: 20230241199
    Abstract: Provided are virus-like particle vaccines for human metapneumovirus (hMPV) in which the ectodomain of hMPV F protein is linked to, and thereby displayed on, a symmetric protein-based virus-like particle. For example, the vaccine antigen may be a N-terminal fusion of the ectodomain of hMPV F protein to a protein having a multimerization domain for a one- or two-component virus-like particle, such as a two-component icosahedral virus-like particle. Further provided are vaccine compositions, methods of manufacturing, and methods of use, e.g., immunizing a subject to generate a protective immune response to hMPV.
    Type: Application
    Filed: March 24, 2023
    Publication date: August 3, 2023
    Inventors: Andrew Lawrence Feldhaus, Douglas Andrew Holtzman, Clancey Buchanan Wolf