Abstract: Implant devices are coated with biologically active compounds, in particular with plant extracts from vinification residues. The implant devices are bone implants, and in particular dental implants. A method for functionalizing a surface of an implant device is includes the steps of a) optionally, treating the surface of the implant device with air, oxygen, argon, nitrogen plasma, and plasma capable of removing the surface layer of hydrocarbon contamination, b) treating the surface of the implant with an amine substrate, c) treating the surface of the implant resulting from step b), alternatively with a marcs extract, and drying the functionalized surface, or by co-adsorbing a marcs extract and hyaluronic acid, and drying the functionalized surface, or by adsorbing hyaluronic acid and post-adsorbing a marcs extract, and drying of the functionalized surface.

Abstract: Implantable devices having antibacterial activity for preventing periprosthetic infections and for improving osteointegration capacity are provided. Methods for making and using such devices are also provided.

Abstract: Compositions for filling tissue defects, such as defects due to loss of soft tissue or resorption of bone tissue around natural teeth (periodontal defects) or implant screws (peri-implant defects), to increase the size of the alveolar ridge, to fill extraction sites and to raise the maxillary sinus are provided. In particular, the invention provides filler materials for dental use, where the material includes a collagen gel cross-linked with polyphenols in a ceramic support matrix. Methods of making and using such compositions are also provided.

Abstract: Implantable devices having antibacterial activity for preventing periprosthetic infections and for improving osteointegration capacity are provided. Methods for making and using such devices are also provided.

Abstract: The present description relates to an implant device, having an improved integration in the tissue of the animal or human body into which it is inserted, when compared to the prior art devices. Particularly, the present description relates to an implant device for the implant in animal or human body, comprising a hyaluronic acid coating, characterized in that said hyaluronic acid is low molecular weight hyaluronic acid or is composed of a mixture of low molecular weight hyaluronic acid and high molecular weight hyaluronic acid, wherein said low molecular weight hyaluronic acid has a molecular weight lower than 80,000 Dalton and said high molecular weight hyaluronic acid has a molecular weight higher than 700,000 Dalton.

Abstract: A method of modifying surfaces of a device, for example, a medical device, is disclosed. The method includes modifying a surface of a device by providing a device, exposing the device to a reactive gas and plasma energy to create a plasma deposited surface on the device, and quenching the device with the reactive gas. The device exhibits changes in its surface properties thereby making it more desirable for an intended use.

Abstract: A method of modifying surfaces of a device, for example, a medical device, is disclosed. The method includes modifying a surface of a device by providing a device, exposing the device to a reactive gas and plasma energy to create a plasma deposited surface on the device, and quenching the device with the reactive gas. The device exhibits changes in its surface properties thereby making it more desirable for an intended use.

Abstract: A method of modifying surfaces of a device, for example, a medical device, is disclosed. The method includes modifying a surface of a device by providing a device, exposing the device to a reactive gas and plasma energy to create a plasma deposited surface on the device, and quenching the device with the reactive gas. The device exhibits changes in its surface properties thereby making it more desirable for an intended use.

Abstract: Processes are provided for coating the surfaces of objects with hyaluronic acid, its derivatives or other natural or semisynthetic polymers, for applications in the fields of surgery, health care and diagnostics. The processes make it possible to bind such polymers in a stable manner to the surfaces of objects made of a wide range of materials. Surfaces treated according to the processes are characterized by a high degree of wettability, and are able to inhibit the adhesion of cells or bacteria present in the biological fluids.